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The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation.
J Biol Chem. 2001 Jan 19;276(3):1961-7.
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Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation.
J Biol Chem. 2000 May 12;275(19):14231-41.
PMID: 10799501 [PubMed - indexed for MEDLINE]
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HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.
EMBO J. 1996 Dec 16;15(24):7013-25.
PMID: 9003777 [PubMed - indexed for MEDLINE]
4: Rana A, Gallo K, Godowski P, Hirai S, Ohno S, Zon L, Kyriakis JM, Avruch J. Related Articles, Links
The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.
J Biol Chem. 1996 Aug 9;271(32):19025-8.
PMID: 8702571 [PubMed - indexed for MEDLINE]
5: Ing YL, Leung IW, Heng HH, Tsui LC, Lassam NJ. Related Articles, Links
MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain.
Oncogene. 1994 Jun;9(6):1745-50.
PMID: 8183572 [PubMed - indexed for MEDLINE]
Time used: 47 miliseconds.

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