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Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
J Med Chem. 2002 Sep 26;45(20):4443-59.
PMID: 12238924 [PubMed - indexed for MEDLINE]
2: Guo XL, Shen K, Wang F, Lawrence DS, Zhang ZY. Related Articles, Links
Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition.
J Biol Chem. 2002 Oct 25;277(43):41014-22.
PMID: 12193602 [PubMed - indexed for MEDLINE]
3: Chen YT, Seto CT. Related Articles, Links
Divalent and trivalent alpha-ketocarboxylic acids as inhibitors of protein tyrosine phosphatases.
J Med Chem. 2002 Aug 29;45(18):3946-52.
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4: Caselli A, Mazzinghi B, Camici G, Manao G, Ramponi G. Related Articles, Links
Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1.
Biochem Biophys Res Commun. 2002 Aug 23;296(3):692-7.
PMID: 12176037 [PubMed - indexed for MEDLINE]
5: Rondinone CM, Trevillyan JM, Clampit J, Gum RJ, Berg C, Kroeger P, Frost L, Zinker BA, Reilly R, Ulrich R, Butler M, Monia BP, Jirousek MR, Waring JF. Related Articles, Links
Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.
Diabetes. 2002 Aug;51(8):2405-11.
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Time used: 47 miliseconds.

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