ID Name Structure References (top 5) Molecular Target(s)
1ID:1008
CHENODEOXYCHOLIC ACID


NSC#:657949
NSC#:657950
NSC#:683769
Aldrich#:224545
Aldrich#:22510
Aldrich#:859109
Aldrich#:94465
Aldrich#:C9377
Aldrich#:U5127
FDA approved!!!

Freqency:
in 1 ingredients:

  • 52
  • in 8 recipes:

  • 2
  • 12
  • 100
  • 125
  • 205
  • 217
  • 271
  • 380

  • Properties
    C24H40O4    392.58





    1:  Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD.
    A natural product that lowers cholesterol as an antagonist ligand for FXR.
    Science.    impact factor:   24.595
    2002;  296(5573): 1703-6

    2:  Jung D, Podvinec M, Meyer UA, Mangelsdorf DJ, Fried M, Meier PJ, Kullak-Ublick GA.
    Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor.
    Gastroenterology.    impact factor:   12.182
    2002;  122(7): 1954-66

    3:  Zhang F, Altorki NK, Wu YC, Soslow RA, Subbaramaiah K, Dannenberg AJ.
    Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids.
    Gastroenterology.    impact factor:   12.182
    2001;  121(6): 1391-9

    4:  Quattropani C, Vogt B, Odermatt A, Dick B, Frey BM, Frey FJ.
    Reduced activity of 11 beta-hydroxysteroid dehydrogenase in patients with cholestasis.
    J Clin Invest.    impact factor:   10.921
    2001;  108(9): 1299-305

    5:  Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA.
    Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
    J Biol Chem.    impact factor:   7.666
    2002;  277(4): 2908-15

     
    Time used: 78 milliseconds.

    Webpage designed by Dr. Xueliang Fang, last updated on 3/10/2005