ID Name Structure References (top 5) Molecular Target(s)
1ID:1285
COSTUNOLIDE


NSC#:106404

Freqency:
in 2 ingredients:

  • 43
  • 356
  • in 48 recipes:

  • 19
  • 20
  • 21
  • 22
  • 23
  • 24
  • 29
  • 30
  • 41
  • 43
  • 48
  • 122
  • 123
  • 124
  • 150
  • 169
  • 221
  • 223
  • 229
  • 233
  • 236
  • 241
  • 242
  • 243
  • 247
  • 248
  • 252
  • 258
  • 260
  • 272
  • 274
  • 279
  • 283
  • 288
  • 294
  • 297
  • 311
  • 401
  • 402
  • 403
  • 434
  • 487
  • 490
  • 497
  • 500
  • 505
  • 513
  • 521

  • Properties
    C15H20O2    232.32





    1:  Kawamori T, Tanaka T, Hara A, Yamahara J, Mori H.
    Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats.
    Cancer Res.    impact factor:   8.614
    1995;  55(6): 1277-82

    2:  de Kraker JW, Franssen MC, Joerink M, de Groot A, Bouwmeester HJ.
    Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome p450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory.
    Plant Physiol.    impact factor:   4.434
    2002;  129(1): 257-68

    3:  Barrero AF, Oltra JE, Alvarez M, Rosales A.
    Synthesis of (+)-8-deoxyvernolepin and its 11,13-dihydroderivative. A novel reaction initiated by sulfene elimination leads to the 2-Oxa-cis-decalin skeleton.
    J Org Chem.    impact factor:   3.44
    2002;  67(16): 5461-9

    4:  Chen HC, Chou CK, Lee SD, Wang JC, Yeh SF.
    Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells.
    Antiviral Res.    impact factor:   2.758
    1995;  27(1-2): 99-109

    5:  Kim SH, Kang SN, Kim HJ, Kim TS.
    Potentiation of 1,25-dihydroxyvitamin D(3)-induced differentiation of human promyelocytic leukemia cells into monocytes by costunolide, a germacranolide sesquiterpene lactone.
    Biochem Pharmacol.    impact factor:   2.755
    2002;  64(8): 1233-42

     
    Time used: 140 milliseconds.

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