ID Name Structure References (top 5) Molecular Target(s)
1ID:222
ALLYL DISULFIDE


NSC#:29228
Aldrich#:317691
Aldrich#:32621

Freqency:
in 1 ingredients:

  • 15

  • Properties
    C6H10S2    146.28





    1:  Bose C, Guo J, Zimniak L, Srivastava SK, Singh SP, Zimniak P, Singh SV.
    Critical role of allyl groups and disulfide chain in induction of Pi class glutathione transferase in mouse tissues in vivo by diallyl disulfide, a naturally occurring chemopreventive agent in garlic.
    Carcinogenesis.    impact factor:   4.118
    2002;  23(10): 1661-5

    2:  Guyonnet D, Belloir C, Suschetet M, Siess MH, Le Bon AM.
    Mechanisms of protection against aflatoxin B(1) genotoxicity in rats treated by organosulfur compounds from garlic.
    Carcinogenesis.    impact factor:   4.118
    2002;  23(8): 1335-41

    3:  Nakagawa H, Tsuta K, Kiuchi K, Senzaki H, Tanaka K, Hioki K, Tsubura A.
    Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines.
    Carcinogenesis.    impact factor:   4.118
    2001;  22(6): 891-7

    4:  Robert V, Mouille B, Mayeur C, Michaud M, Blachier F.
    Effects of the garlic compound diallyl disulfide on the metabolism, adherence and cell cycle of HT-29 colon carcinoma cells: evidence of sensitive and resistant sub-populations.
    Carcinogenesis.    impact factor:   4.118
    2001;  22(8): 1155-61

    5:  Knowles LM, Milner JA.
    Diallyl disulfide inhibits p34(cdc2) kinase activity through changes in complex formation and phosphorylation.
    Carcinogenesis.    impact factor:   4.118
    2000;  21(6): 1129-34

    ARG
    BAX
    BCL-2
    DT diaphorase
    LC
    NADPH CYTOCHROME P450
    P21
    P53
    P450
    ROS
    STEP
    THIOREDOXIN
    THYMIDINE KINASE
    PKC
     
    Time used: 235 milliseconds.

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