ID Name Structure References (top 5) Molecular Target(s)
1ID:234
ALOE-EMODIN


NSC#:38628
Aldrich#:A7687

Freqency:
in 2 ingredients:

  • 14
  • 133
  • in 36 recipes:

  • 4
  • 6
  • 43
  • 98
  • 114
  • 138
  • 145
  • 150
  • 152
  • 154
  • 165
  • 166
  • 196
  • 206
  • 208
  • 210
  • 219
  • 226
  • 228
  • 231
  • 274
  • 289
  • 308
  • 320
  • 364
  • 378
  • 415
  • 428
  • 434
  • 445
  • 458
  • 464
  • 465
  • 519
  • 521
  • 527

  • Properties
    C15H10O5    270.24





    1:  Pecere T, Gazzola MV, Mucignat C, Parolin C, Vecchia FD, Cavaggioni A, Basso G, Diaspro A, Salvato B, Carli M, Palu G.
    Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors.
    Cancer Res.    impact factor:   8.614
    2000;  60(11): 2800-4

    2:  Battistutta R, Sarno S, De Moliner E, Papinutto E, Zanotti G, Pinna LA.
    The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2.
    J Biol Chem.    impact factor:   7.666
    2000;  275(38): 29618-22

    3:  Channavajhala P, Seldin DC.
    Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis.
    Oncogene.    impact factor:   6.517
    2002;  21(34): 5280-8

    4:  Zhang L, Lau YK, Xi L, Hong RL, Kim DS, Chen CF, Hortobagyi GN, Chang C, Hung MC.
    Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties.
    Oncogene.    impact factor:   6.517
    1998;  16(22): 2855-63

    5:  Kumar A, Dhawan S, Aggarwal BB.
    Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells.
    Oncogene.    impact factor:   6.517
    1998;  17(7): 913-8

    BAX
    BCL-2
    C-AMP
    EGFR-1
    EGFR-2
    FAS
    HSC
    HGF
    LC
    LCK
    P21
    P53
    P450
    PI-3K
    ROS
    STEP
    SRC
    PKC
     
    Time used: 265 milliseconds.

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