ID Name Structure References (top 5) Molecular Target(s)
1ID:3377
INDIRUBIN


NSC#:105327

Freqency:
in 2 ingredients:

  • 147
  • 149
  • in 37 recipes:

  • 3
  • 75
  • 76
  • 98
  • 125
  • 139
  • 148
  • 150
  • 154
  • 155
  • 159
  • 206
  • 217
  • 228
  • 289
  • 297
  • 304
  • 325
  • 335
  • 378
  • 385
  • 404
  • 418
  • 432
  • 434
  • 435
  • 437
  • 439
  • 440
  • 444
  • 453
  • 458
  • 496
  • 519
  • 521
  • 525
  • 527

  • Properties
    C16H10N2O2    262.27





    1:  Meyer A, Wursten M, Schmid A, Kohler HP, Witholt B.
    Hydroxylation of indole by laboratory-evolved 2-hydroxybiphenyl 3-monooxygenase.
    J Biol Chem.    impact factor:   7.666
    2002;  277(37): 34161-7

    2:  Adachi J, Mori Y, Matsui S, Takigami H, Fujino J, Kitagawa H, Miller CA 3rd, Kato T, Saeki K, Matsuda T.
    Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine.
    J Biol Chem.    impact factor:   7.666
    2001;  276(34): 31475-8

    3:  Leclerc S, Garnier M, Hoessel R, Marko D, Bibb JA, Snyder GL, Greengard P, Biernat J, Wu YZ, Mandelkow EM, Eisenbrand G, Meijer L.
    Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
    J Biol Chem.    impact factor:   7.666
    2001;  276(1): 251-60

    4:  Damiens E, Baratte B, Marie D, Eisenbrand G, Meijer L.
    Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest.
    Oncogene.    impact factor:   6.517
    2001;  20(29): 3786-97

    5:  Gillam EM, Notley LM, Cai H, De Voss JJ, Guengerich FP.
    Oxidation of indole by cytochrome P450 enzymes.
    Biochemistry.    impact factor:   4.493
    2000;  39(45): 13817-24

     
    Time used: 140 milliseconds.

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