ID Name Structure References (top 5) Molecular Target(s)
1ID:4697
NITIDINE


NSC#:146397(<1uM)

Freqency:
in 2 ingredients:

  • 391
  • 475
  • in 9 recipes:

  • 68
  • 136
  • 199
  • 318
  • 329
  • 332
  • 334
  • 412
  • 483

  • Properties
    C21H18NO4    348.38





    1:  Gatto B, Sanders MM, Yu C, Wu HY, Makhey D, LaVoie EJ, Liu LF.
    Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne.
    Cancer Res.    impact factor:   8.614
    1996;  56(12): 2795-800

    2:  Sethi VS.
    Inhibition of mammalian and oncornavirus nucleic acid polymerase activities by alkoxybenzophenanthridine alkaloids.
    Cancer Res.    impact factor:   8.614
    1976;  36(7 PT 1): 2390-5

    3:  Sim SP, Pilch DS, Liu LF.
    Site-specific topoisomerase I-mediated DNA cleavage induced by nogalamycin: a potential role of ligand-induced DNA bending at a distal site.
    Biochemistry.    impact factor:   4.493
    2000;  39(32): 9928-34

    4:  Wang X, Henningfeld KA, Hecht SM.
    DNA topoisomerase I-mediated formation of structurally modified DNA duplexes. Effects of metal ions and topoisomerase I inhibitors.
    Biochemistry.    impact factor:   4.493
    1998;  37(8): 2691-700

    5:  Goldman GH, Yu C, Wu HY, Sanders MM, La Voie EJ, Liu LF.
    Differential poisoning of human and Aspergillus nidulans DNA topoisomerase I by bi- and terbenzimidazoles.
    Biochemistry.    impact factor:   4.493
    1997;  36(21): 6488-94

     
    Time used: 140 milliseconds.

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