ID Name Structure References (top 5) Molecular Target(s)
1ID:4698
NOBILETIN


NSC#:76751
NSC#:618903

Freqency:
in 6 ingredients:

  • 175
  • 177
  • 420
  • 536
  • 584
  • 716
  • in 59 recipes:

  • 2
  • 8
  • 10
  • 22
  • 23
  • 29
  • 42
  • 43
  • 107
  • 109
  • 111
  • 123
  • 205
  • 212
  • 215
  • 219
  • 223
  • 227
  • 232
  • 233
  • 236
  • 241
  • 242
  • 247
  • 248
  • 254
  • 255
  • 258
  • 259
  • 271
  • 272
  • 273
  • 274
  • 283
  • 286
  • 287
  • 288
  • 291
  • 292
  • 294
  • 296
  • 305
  • 313
  • 331
  • 340
  • 342
  • 346
  • 362
  • 367
  • 383
  • 399
  • 402
  • 405
  • 412
  • 488
  • 494
  • 501
  • 507
  • 515

  • Properties
    C21H22O8    402.4





    1:  Sato T, Koike L, Miyata Y, Hirata M, Mimaki Y, Sashida Y, Yano M, Ito A.
    Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.
    Cancer Res.    impact factor:   8.614
    2002;  62(4): 1025-9

    2:  Murakami A, Nakamura Y, Torikai K, Tanaka T, Koshiba T, Koshimizu K, Kuwahara S, Takahashi Y, Ogawa K, Yano M, Tokuda H, Nishino H, Mimaki Y, Sashida Y, Kitanaka S, Ohigashi H.
    Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice.
    Cancer Res.    impact factor:   8.614
    2000;  60(18): 5059-66

    3:  Buening MK, Chang RL, Huang MT, Fortner JG, Wood AW, Conney AH.
    Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids.
    Cancer Res.    impact factor:   8.614
    1981;  41(1): 67-72

    4:  Huang MT, Wood AW, Newmark HL, Sayer JM, Yagi H, Jerina DM, Conney AH.
    Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids.
    Carcinogenesis.    impact factor:   4.118
    1983;  4(12): 1631-7

    5:  Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW.
    Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.
    Chem Res Toxicol.    impact factor:   3.47
    2001;  14(12): 1596-603

     
    Time used: 109 milliseconds.

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