ID Name Structure References (top 5) Molecular Target(s)
1ID:483
ARTEMISITENE


NSC#:623785(<1uM)

Freqency:
in 1 ingredients:

  • 715
  • in 7 recipes:

  • 6
  • 39
  • 210
  • 269
  • 287
  • 312
  • 334

  • Properties
    C15H20O5    280.32





    1:  Avery MA, Alvim-Gaston M, Vroman JA, Wu B, Ager A, Peters W, Robinson BL, Charman W.
    Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates.
    J Med Chem.    impact factor:   4.079
    2002;  45(19): 4321-35

    2:  Ekthawatchai S, Kamchonwongpaisan S, Kongsaeree P, Tarnchompoo B, Thebtaranonth Y, Yuthavong Y.
    C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene.
    J Med Chem.    impact factor:   4.079
    2001;  44(26): 4688-95

    3:  Paitayatat S, Tarnchompoo B, Thebtaranonth Y, Yuthavong Y.
    Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IX.
    J Med Chem.    impact factor:   4.079
    1997;  40(5): 633-8

    4:  Acton N, Karle JM, Miller RE.
    Synthesis and antimalarial activity of some 9-substituted artemisinin derivatives.
    J Med Chem.    impact factor:   4.079
    1993;  36(17): 2552-7

    5:  Ma J, Weiss E, Kyle DE, Ziffer H.
    Acid catalyzed Michael additions to artemisitene.
    Bioorg Med Chem Lett.    impact factor:   1.759
    2000;  10(14): 1601-3

    STEP
     
    Time used: 94 milliseconds.

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