ID Name Structure References (top 5) Molecular Target(s)
1ID:616
BERBAMINE


NSC#:93135
NSC#:105131
NSC#:121842
NSC#:263873
NSC#:273752
NSC#:645315

Freqency:
in 9 ingredients:

  • 10
  • 98
  • 308
  • 342
  • 374
  • 380
  • 470
  • 477
  • 568
  • in 27 recipes:

  • 1
  • 3
  • 10
  • 16
  • 30
  • 38
  • 50
  • 55
  • 71
  • 81
  • 82
  • 84
  • 86
  • 91
  • 108
  • 113
  • 115
  • 121
  • 156
  • 160
  • 182
  • 193
  • 215
  • 286
  • 390
  • 476
  • 519

  • Properties
    C37H40N2O6    608.73





    1:  Shiraishi N, Akiyama S, Nakagawa M, Kobayashi M, Kuwano M.
    Effect of bisbenzylisoquinoline (biscoclaurine) alkaloids on multidrug resistance in KB human cancer cells.
    Cancer Res.    impact factor:   8.614
    1987;  47(9): 2413-6

    2:  Xu YH, Liu J, Zhang SP, Liu LH.
    The effect of berbamine derivatives on activated Ca2+-stimulated Mg2+-dependent ATPase in erythrocyte membranes.
    Biochem J.    impact factor:   4.349
    1987;  248(3): 985-8

    3:  Marshall SJ, Russell PF, Wright CW, Anderson MM, Phillipson JD, Kirby GC, Warhurst DC, Schiff PL Jr.
    In vitro antiplasmodial, antiamoebic, and cytotoxic activities of a series of bisbenzylisoquinoline alkaloids.
    Antimicrob Agents Chemother.    impact factor:   3.969
    1994;  38(1): 96-103

    4:  Hu ZY, Chen SL, Hao ZG, Huang WL, Peng SX.
    Benzylisoquinoline compounds inhibit the ability of calmodulin to activate cyclic nucleotide phosphodiesterase.
    Cell Signal.    impact factor:   3.509
    1989;  1(2): 181-5

    5:  Xu YH, Zhang SP.
    A derivative of bisbenzylisoquinoline alkaloid is a new and potential calmodulin antagonist.
    Biochem Biophys Res Commun.    impact factor:   3.161
    1986;  140(1): 461-7

    BAX
    BCL-2
    C-AMP
    MET
    P53
    STEP
    PKC
     
    Time used: 250 milliseconds.

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