ID Name Structure References (top 5) Molecular Target(s)
1ID:716
BRUSATOL


NSC#:172924(<1uM)

Freqency:
in 1 ingredients:

  • 191
  • in 7 recipes:

  • 15
  • 34
  • 76
  • 185
  • 265
  • 335
  • 341

  • Properties
    C26H32O11    520.53





    1:  Mata-Greenwood E, Cuendet M, Sher D, Gustin D, Stock W, Pezzuto JM.
    Brusatol-mediated induction of leukemic cell differentiation and G(1) arrest is associated with down-regulation of c-myc.
    Leukemia.    impact factor:   3.562
    2002;  16(11): 2275-84

    2:  Willingham W 3rd, Considine RT, Chaney SG, Lee KH, Hall IH.
    Reversibility of protein synthesis inhibition by quassinoid antineoplastic agents in a rabbit reticulocyte system.
    Biochem Pharmacol.    impact factor:   2.755
    1984;  33(2): 330-3

    3:  Willingham W Jr, Stafford EA, Reynolds SH, Chaney SG, Lee KH, Okano M, Hall IH.
    Mechanism of eukaryotic protein synthesis inhibition by brusatol.
    Biochim Biophys Acta.    impact factor:   2.59
    1981;  654(2): 169-74

    4:  Hall IH, Lee KH, Imakura Y, Okano M, Johnson A.
    Anti-inflammatory agents III: Structure-activity relationships of brusatol and related quassinoids.
    J Pharm Sci.    impact factor:   2.27
    1983;  72(11): 1282-4

    5:  Hall IH, Liou YF, Lee KH, Chaney SG, Willingham W Jr.
    Antitumor agents LIX: effects of quassinoids on protein synthesis of a number of murine tumors and normal cells.
    J Pharm Sci.    impact factor:   2.27
    1983;  72(6): 626-30

    C-AMP
    MET
    STEP
    THYMIDYLATE SYNTHETASE
     
    Time used: 157 milliseconds.

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