ID Name Structure References (top 5) Molecular Target(s)
1ID:7175
DIHYDROCOSTUNOLIDE

Freqency:
in 1 ingredients:

  • 43
  • in 48 recipes:

  • 19
  • 20
  • 21
  • 22
  • 23
  • 24
  • 29
  • 30
  • 41
  • 43
  • 48
  • 122
  • 123
  • 124
  • 150
  • 169
  • 221
  • 223
  • 229
  • 233
  • 236
  • 241
  • 242
  • 243
  • 247
  • 248
  • 252
  • 258
  • 260
  • 272
  • 274
  • 279
  • 283
  • 288
  • 294
  • 297
  • 311
  • 401
  • 402
  • 403
  • 434
  • 487
  • 490
  • 497
  • 500
  • 505
  • 513
  • 521

  • Properties
    C15H22O2    234.34





    1:  Corey EJ, Hortmann AG.
    The total synthesis of dihydrocostunolide.
    J Am Chem Soc.    impact factor:   5.537
    1965;  87(24): 5736-42

    2:  de Kraker JW, Franssen MC, Joerink M, de Groot A, Bouwmeester HJ.
    Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome p450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory.
    Plant Physiol.    impact factor:   4.434
    2002;  129(1): 257-68

    3:  Barrero AF, Oltra JE, Cuerva JM, Rosales A.
    Effects of solvents and water in Ti(III)-mediated radical cyclizations of epoxygermacrolides. Straightforward synthesis and absolute stereochemistry of (+)-3alpha-hydroxyreynosin and related eudesmanolides.
    J Org Chem.    impact factor:   3.44
    2002;  67(8): 2566-71

    4:  Choi JH, Ha J, Park JH, Lee JY, Lee YS, Park HJ, Choi JW, Masuda Y, Nakaya K, Lee KT.
    Costunolide triggers apoptosis in human leukemia U937 cells by depleting intracellular thiols.
    Jpn J Cancer Res.    impact factor:   2.12
    2002;  93(12): 1327-33

    5:  Kawamata T, Takenaka K, Tsuji T.
    [Reaction of 3-hydroxy-dihydrosantonin with TsOH. A formal synthesis of dihydrocotunolide]
    Yakugaku Zasshi.    impact factor:   .238
    1996;  116(9): 748-52

     
    Time used: 110 milliseconds.

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