ID Name Structure References (top 5) Molecular Target(s)
1ID:7349
ISOCOLCHICINE


NSC#:527981
NSC#:628992

Freqency:
in 1 ingredients:

  • 325
  • in 16 recipes:

  • 206
  • 253
  • 271
  • 316
  • 332
  • 344
  • 345
  • 394
  • 399
  • 400
  • 410
  • 421
  • 433
  • 455
  • 466
  • 513

  • Properties
    C22H25NO6    399.44





    1:  Hastie SB, Williams RC Jr, Puett D, Macdonald TL.
    The binding of isocolchicine to tubulin. Mechanisms of ligand association with tubulin.
    J Biol Chem.    impact factor:   7.666
    1989;  264(12): 6682-8

    2:  Morgan JL, Spooner BS.
    Immunological detection of microtubule poison-induced conformational changes in tubulin.
    J Biol Chem.    impact factor:   7.666
    1983;  258(21): 13127-33

    3:  Wolff J, Hwang J, Sackett DL, Knipling L.
    Colchicine photosensitizes covalent tubulin dimerization.
    Biochemistry.    impact factor:   4.493
    1992;  31(16): 3935-40

    4:  Dumortier C, Yan Q, Bane S, Engelborghs Y.
    Mechanism of tubulin-colchicine recognition: a kinetic study of the binding of the colchicine analogues colchicide and isocolchicine.
    Biochem J.    impact factor:   4.349
    1997;  327 ( Pt 3): 685-8

    5:  Staretz ME, Hastie SB.
    Synthesis and tubulin binding of novel C-10 analogues of colchicine.
    J Med Chem.    impact factor:   4.079
    1993;  36(6): 758-64

     
    Time used: 109 milliseconds.

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