ID Name Structure References (top 5) Molecular Target(s)
1ID:7500
NITIDINE CHLORIDE

Freqency:
in 1 ingredients:

  • 391
  • in 9 recipes:

  • 68
  • 136
  • 199
  • 318
  • 329
  • 332
  • 334
  • 412
  • 483

  • Properties
    C21H18ClNO4    383.83





    1:  Gatto B, Sanders MM, Yu C, Wu HY, Makhey D, LaVoie EJ, Liu LF.
    Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne.
    Cancer Res.    impact factor:   8.614
    1996;  56(12): 2795-800

    2:  Sethi VS.
    Inhibition of mammalian and oncornavirus nucleic acid polymerase activities by alkoxybenzophenanthridine alkaloids.
    Cancer Res.    impact factor:   8.614
    1976;  36(7 PT 1): 2390-5

    3:  Wang X, Henningfeld KA, Hecht SM.
    DNA topoisomerase I-mediated formation of structurally modified DNA duplexes. Effects of metal ions and topoisomerase I inhibitors.
    Biochemistry.    impact factor:   4.493
    1998;  37(8): 2691-700

    4:  Janin YL, Croisy A, Riou JF, Bisagni E.
    Synthesis and evaluation of new 6-amino-substituted benzo[c]phenanthridine derivatives.
    J Med Chem.    impact factor:   4.079
    1993;  36(23): 3686-92

    5:  Cushman M, Mohan P, Smith EC.
    Synthesis and biological activity of structural analogues of the anticancer benzophenanthridine alkaloid nitidine chloride.
    J Med Chem.    impact factor:   4.079
    1984;  27(4): 544-7

     
    Time used: 110 milliseconds.

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