ID Name Structure References (top 5) Molecular Target(s)
1ID:7681
RHAPONTIC ACID


NSC#:112929(<1uM)
NSC#:112930

Freqency:
in 1 ingredients:

  • 14
  • in 34 recipes:

  • 4
  • 6
  • 43
  • 98
  • 114
  • 138
  • 145
  • 150
  • 152
  • 154
  • 165
  • 166
  • 196
  • 206
  • 208
  • 210
  • 219
  • 226
  • 228
  • 231
  • 274
  • 289
  • 320
  • 364
  • 378
  • 415
  • 428
  • 434
  • 445
  • 464
  • 465
  • 519
  • 521
  • 527

  • Properties
    C16H24O4    280.36





    1:  Staumont G, Fioramonti J, Frexinos J, Bueno L.
    Changes in colonic motility induced by sennosides in dogs: evidence of a prostaglandin mediation.
    Gut.    impact factor:   5.748
    1988;  29(9): 1180-7

    2:  Kiernan JA, Heinicke EA.
    Sennosides do not kill myenteric neurons in the colon of the rat or mouse.
    Neuroscience.    impact factor:   3.924
    1989;  30(3): 837-42

    3:  van Gorkom BA, Karrenbeld A, van der Sluis T, Zwart N, de Vries EG, Kleibeuker JH.
    Apoptosis induction by sennoside laxatives in man; escape from a protective mechanism during chronic sennoside use?
    J Pathol.    impact factor:   3.833
    2001;  194(4): 493-9

    4:  Akao T, Che QM, Kobashi K, Yang L, Hattori M, Namba T.
    Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins.
    Appl Environ Microbiol.    impact factor:   3.541
    1994;  60(3): 1041-3

    5:  van Gorkom BA, Timmer-Bosscha H, de Jong S, van der Kolk DM, Kleibeuker JH, de Vries EG.
    Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1.
    Br J Cancer.    impact factor:   3.282
    2002;  86(9): 1494-500

     
    Time used: 485 milliseconds.

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