Ingredient ID 114 
Chinese Pronunciation ROUGUI 
English Name Cassia Bark  
Latin Name Cortex Cinnamomi  
Aliases GuiFu
Cancers Nourish  
Identified Compounds

order by name

1. Choline

   C5H14NO   104.17

2. Cinnamic Acid

   C9H8O2   148.16

3. Cinnamic Aldehyde

   C9H8O   132.16

4. Cinnamyl Acetate

   C11H12O2   176.21

5. Coumarin

   C9H6O2   146.14
NSC# 8774 Activity (but inactive >10uM)

6. Eugenol

   C10H12O2   164.2

7. Protocatechuic Acid

   C7H6O4   154.12

8. Beta-sitosterol

   C29H50O   414.71

9. Cinnzeylanine

   C20H30O6   366.45

10. Cinnzeylanol

   C20H32O7   384.46

11. Phenylpropy Acetate

   C11H14O2   178.23

Recipes that contain
  1. 80      AiDiWan
  2. 102      GuaLouGongYinTang
  3. 157      WuXiongTang
  4. 231      KangAiSan(Wan, Gao)
  5. 233      QuanYangWan
  6. 342      AiDiWan
  7. 382      GuaLouGongYingTang
  8. 446      BaiXueBingFangII
  9. 474      GuLiuSan
  10. 497      ShiGuanAiCanKaoFangIII

Available references (order by impact factor):

1:  Hyde GJ, Hardham AR.
Microtubules regulate the generation of polarity in zoospores of Phytophthora cinnamomi.
Eur J Cell Biol.    impact factor:   3.043
1993;  62(1): 75-85

2:  Gong F, Liang YZ, Xu QS, Chau FT.
Gas chromatography-mass spectrometry and chemometric resolution applied to the determination of essential oils in Cortex cinnamomi.
J Chromatogr A.    impact factor:   2.52
2001;  905(1-2): 193-205

3:  Buchalter L.
Identification of polymeric 5,7,3',4'-tetrahydroxyflavan-3,4-diol from tannin extract of powdered cassia bark, Saigon, cinnamon USP, Cinnamomum loureirii Nees, family Lauraceae.
J Pharm Sci.    impact factor:   2.27
1971;  60(1): 144-5

4:  Sugaya E, Ishige A, Sekiguchi K, Iizuka S, Ito K, Sugimoto A, Aburada M, Hosoya E.
Inhibitory effect of TJ-960 (SK) on pentylenetetrazol-induced EEG power spectrum changes.
Epilepsy Res.    impact factor:   2.193
1988;  2(1): 27-31

5:  Sakai Y, Nagase H, Ose Y, Sato T, Kawai M, Mizuno M.
Effects of medicinal plant extracts from Chinese herbal medicines on the mutagenic activity of benzo[a]pyrene.
Mutat Res.    impact factor:   2.107
1988;  206(3): 327-34

6:  Sekizawa J, Shibamoto T.
Genotoxicity of safrole-related chemicals in microbial test systems.
Mutat Res.    impact factor:   2.107
1982;  101(2): 127-40

7:  Ohdo S, Ogawa N, Song JG, Higuchi S.
Chronopharmacological study of KE-SI-TO components in mice.
Life Sci.    impact factor:   1.774
1998;  62(22): 2057-64

8:  Lee HS, Kim BS, Kim MK.
Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase.
J Agric Food Chem.    impact factor:   1.56
2002;  50(26): 7700-3

9:  Park IK, Lee HS, Lee SG, Park JD, Ahn YJ.
Insecticidal and fumigant activities of Cinnamomum cassia bark-derived materials against Mechoris ursulus (Coleoptera: attelabidae).
J Agric Food Chem.    impact factor:   1.56
2000;  48(6): 2528-31

10:  Lee HS, Ahn YJ.
Growth-Inhibiting Effects of Cinnamomum cassia Bark-Derived Materials on Human Intestinal Bacteria.
J Agric Food Chem.    impact factor:   1.56
1998;  46(1): 8-12

11:  Cheng JT, Liu IM, Chi TC, Su HC, Chang CG.
Metformin-like effects of Quei Fu Di Huang Wan, a Chinese herbal mixture, on streptozotocin-induced diabetic rat.
Horm Metab Res.    impact factor:   1.465
2001;  33(12): 727-32

12:  Yamada H, Kiyohara H, Takemoto N, Zhao JF, Kawamura H, Komatsu Y, Cyong JC, Aburada M, Hosoya E.
Mitogenic and complement activating activities of the herbal components of juzen-taiho-to.
Planta Med.    impact factor:   1.438
1992;  58(2): 166-70

13:  Tanaka S, Yoon YH, Fukui H, Tabata M, Akira T, Okano K, Iwai M, Iga Y, Yokoyama K.
Antiulcerogenic compounds isolated from Chinese cinnamon.
Planta Med.    impact factor:   1.438
1989;  55(3): 245-8

14:  Tiwari RD, Bajpai M, Tiwari AR, Singh J.
Chemical examination of the stem bark of Cassia renigera.
Planta Med.    impact factor:   1.438
1977;  32(4): 371-4

15:  Suzuki F, Kobayashi M, Komatsu Y, Kato A, Pollard RB.
Keishi-ka-kei-to, a traditional Chinese herbal medicine, inhibits pulmonary metastasis of B16 melanoma.
Anticancer Res.    impact factor:   1.375
1997;  17(2A): 873-8

16:  Koh WS, Yoon SY, Kwon BM, Jeong TC, Nam KS, Han MY.
Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation.
Int J Immunopharmacol.    impact factor:   1.142
1998;  20(11): 643-60

17:  Mino Y, Ota N.
Inorganic chemical approaches to pharmacognosy. V. X-ray fluorescence spectrometric studies on the inorganic constituents of crude drugs. (3). On the cinnamomi cortex.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
1990;  38(3): 709-13

18:  Kanari M, Tomoda M, Gonda R, Shimizu N, Kimura M, Kawaguchi M, Kawabe C.
A reticuloendothelial system-activating arabinoxylan from the bark of Cinnamomum cassia.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
1989;  37(12): 3191-4

19:  Matsuda H, Matsuda R, Fukuda S, Shiomoto H, Kubo M.
Anti-thrombic actions of 70% methanolic extract and cinnamic aldehyde from cinnamomi cortex.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
1987;  35(3): 1275-80

20:  Koyama J, Morita I, Tagahara K, Aqil MB.
Bianthraquinones from Cassia siamea.
Phytochemistry.    impact factor:   1.106
2001;  56(8): 849-51

21:  Coetzee J, Mciteka L, Malan E, Ferreira D.
Structure and synthesis of the first procassinidin dimers based on epicatechin, and gallo- and epigallo-catechin.
Phytochemistry.    impact factor:   1.106
2000;  53(7): 795-804

22:  Bang KH, Lee DW, Park HM, Rhee YH.
Inhibition of fungal cell wall synthesizing enzymes by trans-cinnamaldehyde.
Biosci Biotechnol Biochem.    impact factor:   1.039
2000;  64(5): 1061-3

23:  Wu HG, Zhou LB, Pan YY, Huang C, Chen HP, Shi Z, Hua XG.
Study of the mechanisms of acupuncture and moxibustion treatment for ulcerative colitis rats in view of the gene expression of cytokines.
World J Gastroenterol.    impact factor:   .993
1999;  5(6): 515-517

24:  Onishi Y, Yamaura T, Tauchi K, Sakamoto T, Tsukada K, Nunome S, Komatsu Y, Saiki I.
Expression of the anti-metastatic effect induced by Juzen-taiho-to is based on the content of Shimotsu-to constituents.
Biol Pharm Bull.    impact factor:   .844
1998;  21(7): 761-5

25:  Kubo M, Ma S, Wu J, Matsuda H.
Anti-inflammatory activities of 70% methanolic extract from Cinnamomi Cortex.
Biol Pharm Bull.    impact factor:   .844
1996;  19(8): 1041-5

26:  Nakamoto K, Sadamori S, Hamada T.
Effects of crude drugs and berberine hydrochloride on the activities of fungi.
J Prosthet Dent.    impact factor:   .767
1990;  64(6): 691-4

27:  Lans C, Harper T, Georges K, Bridgewater E.
Medicinal plants used for dogs in Trinidad and Tobago.
Prev Vet Med.    impact factor:   .735
2000;  45(3-4): 201-20

28:  Mena-Rejon GJ, Perez-Rivas K, Sansorez-Peraza P, Rios T, Quijano L.
Racemochrysone, a dihydroanthracenone from Senna racemosa.
Z Naturforsch [C].    impact factor:   .709
2002;  57(9-10): 777-9

29:  Yun YP, Do JH, Ko SR, Ryu SY, Kim JH, Song HC, Park YD, Ahn KS, Kim SH.
Effects of Korean red ginseng and its mixed prescription on the high molecular weight dextran-induced blood stasis in rats and human platelet aggregation.
J Ethnopharmacol.    impact factor:   .687
2001;  77(2-3): 259-64

30:  Tona L, Ngimbi NP, Tsakala M, Mesia K, Cimanga K, Apers S, De Bruyne T, Pieters L, Totte J, Vlietinck AJ.
Antimalarial activity of 20 crude extracts from nine African medicinal plants used in Kinshasa, Congo.
J Ethnopharmacol.    impact factor:   .687
1999;  68(1-3): 193-203

31:  Caceres A, Lopez B, Juarez X, del Aguila J, Garcia S.
Plants used in Guatemala for the treatment of dermatophytic infections. 2. Evaluation of antifungal activity of seven American plants.
J Ethnopharmacol.    impact factor:   .687
1993;  40(3): 207-13

32:  Sakamoto S, Kudo H, Kawasaki T, Kuwa K, Kasahara N, Sassa S, Okamoto R.
Effects of a Chinese herbal medicine, keishi-bukuryo-gan, on the gonadal system of rats.
J Ethnopharmacol.    impact factor:   .687
1988;  23(2-3): 151-8

33:  Watanabe H, Kobayashi T, Tomii M, Sekiguchi Y, Uchida K, Aoki T, Cyong JC.
Effects of Kampo herbal medicine on plasma melatonin concentration in patients.
Am J Chin Med.    impact factor:   .583
2002;  30(1): 65-71

34:  Kanai S, Okano H, Abe H.
Efficacy of toki-shigyakuka-gosyuyu-syokyo-to (danggui-sini-jia-wuzhuyu-shengjiang-tang) on peripheral circulation in autonomic disorders.
Am J Chin Med.    impact factor:   .583
1997;  25(1): 69-78

35:  Sakamoto S, Yoshino H, Shirahata Y, Shimodairo K, Okamoto R.
Pharmacotherapeutic effects of kuei-chih-fu-ling-wan (keishi-bukuryo-gan) on human uterine myomas.
Am J Chin Med.    impact factor:   .583
1992;  20(3-4): 313-7

36:  Choi J, Lee KT, Ka H, Jung WT, Jung HJ, Park HJ.
Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties.
Arch Pharm Res.    impact factor:   .382
2001;  24(5): 418-23

37:  Kwon BM, Lee SH, Choi SU, Park SH, Lee CO, Cho YK, Sung ND, Bok SH.
Synthesis and in vitro cytotoxicity of cinnamaldehydes to human solid tumor cells.
Arch Pharm Res.    impact factor:   .382
1998;  21(2): 147-52

38:  Premanathan M, Rajendran S, Ramanathan T, Kathiresan K, Nakashima H, Yamamoto N.
A survey of some Indian medicinal plants for anti-human immunodeficiency virus (HIV) activity.
Indian J Med Res.    impact factor:   .365
2000;  112: 73-7

39:  Toda S.
Inhibitory effects of aromatic herbs on lipid peroxidation and protein oxidative modification of mice brain homogenate by copper in vitro.
Phytother Res.    impact factor:   .364
2001;  15(6): 541-3

40:  Shimada Y, Goto H, Kogure T, Kohta K, Shintani T, Itoh T, Terasawa K.
Extract prepared from the bark of Cinnamomum cassia Blume prevents glutamate-induced neuronal death in cultured cerebellar granule cells.
Phytother Res.    impact factor:   .364
2000;  14(6): 466-8

41:  Mantani N, Sakai S, Kogure T, Goto H, Shibahara N, Kita T, Shimada Y, Terasawa K.
Herbal medicine and false-positive results on lymphocyte transformation test.
Yakugaku Zasshi.    impact factor:   .238
2002;  122(6): 399-402

42:  Satoh K, Nagai F, Seto T, Yamauchi H.
[The effects of kampo-formulation and the constituting crude drugs, prescribed for the treatment of peptic ulcer on H,K-ATPase activity]
Yakugaku Zasshi.    impact factor:   .238
2001;  121(2): 173-8

43:  Mikage M, Komatsu K, Namba T.
[Fundamental studies on the evaluation of crude drugs. IX. Soft X-ray analysis on crude drugs. (1). Evaluation on the quality of cinnamomi veri cortex by microradiogram]
Yakugaku Zasshi.    impact factor:   .238
1987;  107(3): 192-8

44:  Nakano K, Nohara T, Tomimatsu T, Nishioka I.
[Studies on the constituents of cinnamomi cortex. VI. On the mass spectrometry of cassia diterpene (lactone type) (author's transl)]
Yakugaku Zasshi.    impact factor:   .238
1981;  101(11): 1052-5

45:  Yokozawa T, Chen CP, Tanaka T.
Direct scavenging of nitric oxide by traditional crude drugs.
Phytomedicine.    impact factor:   .185
2000;  6(6): 453-63

46:  Abo KA, Adeyemi AA.
Seasonal accumulation of anthraquinones in leaves of cultivated Cassia podocarpa Guill et Perr.
Afr J Med Med Sci.    impact factor:   0
2002;  31(2): 171-3

47:  Motoo Y, Su SB, Xie MJ, Mouri H, Taga H, Sawabu N.
Effect of herbal medicine keishi-to (TJ-45) and its components on rat pancreatic acinar cell injuries in vivo and in vitro.
Pancreatology.    impact factor:   0
2001;  1(2): 102-9

48:  Tona L, Mesia K, Ngimbi NP, Chrimwami B, Okond'ahoka, Cimanga K, de Bruyne T, Apers S, Hermans N, Totte J, Pieters L, Vlietinck AJ.
In-vivo antimalarial activity of Cassia occidentalis, Morinda morindoides and Phyllanthus niruri.
Ann Trop Med Parasitol.    impact factor:   0
2001;  95(1): 47-57

49:  Zhu S, Liu P, Sun S.
[Identification of Cortex Cinnamomi and its confused species "yin xiang" by FT-Raman spectroscopy]
Zhong Yao Cai.    impact factor:   0
2001;  24(9): 636-7

50:  Wang G, Lu Y, Zhang J, Zhou J, Tian J, Zheng Q, Chen D.
[The powder X-ray diffraction analysis with Fourier spectrum of Chinese material medica Cortex Cinnamomi]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1998;  23(10): 584-7, 638

51:  Yu Z, Zhang G, Dai Y, Kou J, Dou C, Lu R.
[Pharmacological study on the compatibility of cortex Cinnamomi with Halloysitum Rubrum]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1997;  22(5): 309-12 inside back cover

52:  Chang JY, Yang TY, Chang CP, Chang JG.
The effect of "chi-han (hot nature)" Chinese herbs on the secretion of IL-1 beta and TNF-alpha by mononuclear cells.
Kaohsiung J Med Sci.    impact factor:   0
1996;  12(1): 18-24

53:  Mayanagi M.
[The names of drugs in the cassia-bark family in China prior to the 11th century--On the standardization as Guizhi by Ling Yi and other scholars of cassia-bark family drug names appearing in the medical works written by Zhongjing]
Yakushigaku Zasshi.    impact factor:   0
1995;  30(2): 96-115

54:  Parry O, Mutangadura N, Duri ZJ.
The effects of Cassia abbreviata on rat blood pressure.
Cent Afr J Med.    impact factor:   0
1992;  38(11): 435-8

55:  Liu W, Sun X, Zheng L.
[Determination of cinnamaldehyde in cortex Cinnamomi by CS-930 TLC scanner]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1992;  17(6): 358-9, 384

56:  Yang HZ, Liang YH, Ren H.
[Effect of compound and minor prescription of heat-nature products radix Aconiti lateralis preparata, rhizoma Zingiberis and cortex Cinnamomi on the sympathetic nervous system, adrenal gland, TSH and LH]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1992;  17(11): 688-90, 704

57:  Kilian HD, Jahn K, Kraus L, Buttner DW.
In vivo and in vitro effects of extracts from Cassia aubrevillei in onchocerciasis.
Acta Leiden.    impact factor:   0
1990;  59(1-2): 365-71

58:  Chen MD, Kuang AK, Chen JL.
[Influence of yang-restoring herb medicines upon metabolism of thyroid hormone in normal rats and a drug administration schedule]
Zhong Xi Yi Jie He Za Zhi.    impact factor:   0
1989;  9(2): 93-5, 70

59:  Sagara K, Oshima T, Yoshida T, Tong YY, Zhang G, Chen YH.
Determination of Cinnamomi Cortex by high-performance liquid chromatography.
J Chromatogr.    impact factor:   0
1987;  409: 365-70

60:  Takenaga M, Hirai A, Terano T, Tamura Y, Kitagawa H, Yoshida S.
In vitro effect of cinnamic aldehyde, a main component of Cinnamomi Cortex, on human platelet aggregation and arachidonic acid metabolism.
J Pharmacobiodyn.    impact factor:   0
1987;  10(5): 201-8

61:  Suzuki H, Noguchi M, Harada M.
[Search for a marker substance of Cinnamomi cortex leading to quality evaluation of a Chinese-medicinal formulation "gorei-san"]
Eisei Shikenjo Hokoku.    impact factor:   0
1987;  (105): 7-12

62:  Gu DG, Kuang AK.
[Experimental research on the yin-yang theory in traditional Chinese medicine (III). The effect of monkshood, bark of the Chinese cassia tree and liu wei di huang fang on the enkephalin of brain tissue in renovascular hypertensive rats]
Zhong Xi Yi Jie He Za Zhi.    impact factor:   0
1985;  5(2): 105-7, 69

63:  Kuang AK, Gu DG.
[Experimental research on the yin-yang theory in traditional Chinese medicine (IV): The effect of monkshood, bark of the Chinese cassia tree and liu wei di huang fang on the myocardium of renovascular hypertensive rats]
Zhong Xi Yi Jie He Za Zhi.    impact factor:   0
1985;  5(3): 167-8, 132

64:  Yamada M.
[Transition of glycyrrhizae radix and cinnamomi cortex as crude drug preparations between 1886 (J.P.I) and 1981 (J.P.X)] (Jpn).]
Yakushigaku Zasshi.    impact factor:   0
1985;  20(2): 117-25

65:  Gu DG, Kuang AK.
[Experimental research of yin yang theory in traditional Chinese medicine (II): Effect of monkshood, bark of Chinese cassia tree and liu wei di huang fang on urinary aldosterone, etc. in renovascular hypertensive rats]
Zhong Xi Yi Jie He Za Zhi.    impact factor:   0
1985;  5(1): 48-50, 5

66:  Kuang AK.
[Experimental research on the yin-yang theory of traditional Chinese medicine. I. Effect of monkshood, bark of the Chinese Cassia tree and Liu wei di huang fang on arterial pressure in the experimental hypertensive rat]
Zhong Xi Yi Jie He Za Zhi.    impact factor:   0
1984;  4(12): 742-4

67:  Okabe S, Takeuchi K, Ikenishi H, Ohmi F, Takaoka A.
[Effects of SM powder, a combined herbal preparation for stomach diseases, on gastric secretion and acute gastro-duodenal lesions in rats]
Nippon Yakurigaku Zasshi.    impact factor:   0
1983;  81(4): 285-94

68:  Chen Y.
[Pharmacological studies of Cinnamomum cassia bark. Part I. Effects on the blood and cardiovascular system (author's transl)]
Zhong Yao Tong Bao.    impact factor:   0
1981;  6(5): 32-4


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