Ingredient ID 123 
Chinese Pronunciation FANGJI 
English Name Fourstamen Stephania Root  
Latin Name Radix Stephaniae Tetrandrae  
Aliases HanFangJi
Cancers Lung
Identified Compounds

order by name

1. Cissamine

   C20H24NO4   342.41

2. Sinomenin

   C19H23NO4   329.39

3. Fanchinin

   C38H42N2O6   622.76
NSC# 77037 Activity (<1uM)
NSC# 91771 Activity (but inactive >10uM)
NSC# 97338 Activity (<10uM)
NSC# 105130 Activity (<10uM)

4. Fangchinoline

   C37H40N2O6   608.73
NSC# 77036 Activity (<10uM)

5. Thunbergin


Recipes that contain
  1. 113      HuangBaiTang
  2. 381      RuAiFang

Available references (order by impact factor):

1:  Shen YC, Chou CJ, Chiou WF, Chen CF.
Anti-inflammatory effects of the partially purified extract of radix Stephaniae tetrandrae: comparative studies of its active principles tetrandrine and fangchinoline on human polymorphonuclear leukocyte functions.
Mol Pharmacol.    impact factor:   5.465
2001;  60(5): 1083-90

2:  Liu QY, Karpinski E, Rao MR, Pang PK.
Tetrandrine: a novel calcium channel antagonist inhibits type I calcium channels in neuroblastoma cells.
Neuropharmacology.    impact factor:   4.176
1991;  30(12A): 1325-31

3:  Yu XC, Wu S, Wang GY, Shan J, Wong TM, Chen CF, Pang KT.
Cardiac effects of the extract and active components of radix stephaniae tetrandrae. II. Myocardial infarct, arrhythmias, coronary arterial flow and heart rate in the isolated perfused rat heart.
Life Sci.    impact factor:   1.774
2001;  68(25): 2863-72

4:  Wu S, Yu XC, Shan J, Wong TM, Chen CF, Pang KT.
Cardiac effects of the extract and active components of Radix stephaniae tetrandrae. I. Electrically-induced intracellular calcium transient and protein release during the calcium paradox.
Life Sci.    impact factor:   1.774
2001;  68(25): 2853-61

5:  Nakaoji K, Nayeshiro H, Tanahashi T, Su Y, Nagakura N.
Bisbenzylisoquinoline alkaloids from Stephania cepharantha and their effects on proliferation of cultured cells from the murine hair apparatus.
Planta Med.    impact factor:   1.438
1997;  63(5): 425-8

6:  Lee JH, Kang GH, Kim KC, Kim KM, Park DI, Choi BT, Kang HS, Lee YT, Choi YH.
Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells.
Int J Oncol.    impact factor:   1.381
2002;  21(6): 1239-44

7:  Tanahashi T, Su U, Nagakura N, Nayeshiro H.
Quaternary isoquinoline alkaloids from Stephania cepharantha.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
2000;  48(3): 370-3

8:  Kawashima K, Hayakawa T, Miwa Y, Oohata H, Suzuki T, Fujimoto K, Ogino T, Chen ZX.
Structure and hypotensive activity relationships of tetrandrine derivatives in stroke-prone spontaneously hypertensive rats.
Gen Pharmacol.    impact factor:   1.105
1990;  21(3): 343-7

9:  Nawawi A, Ma C, Nakamura N, Hattori M, Kurokawa M, Shiraki K, Kashiwaba N, Ono M.
Anti-herpes simplex virus activity of alkaloids isolated from Stephania cepharantha.
Biol Pharm Bull.    impact factor:   .844
1999;  22(3): 268-74

10:  Kobayashi S, Kimura I, Fukuta M, Kontani H, Inaba K, Niwa M, Mita S, Kimura M.
Inhibitory effects of tetrandrine and related synthetic compounds on angiogenesis in streptozotocin-diabetic rodents.
Biol Pharm Bull.    impact factor:   .844
1999;  22(4): 360-5

11:  Yoo SM, Oh SH, Lee SJ, Lee BW, Ko WG, Moon CK, Lee BH.
Inhibition of proliferation and induction of apoptosis by tetrandrine in HepG2 cells.
J Ethnopharmacol.    impact factor:   .687
2002;  81(2): 225-9

12:  Ma CM, Nakamura N, Miyashiro H, Hattori M, Komatsu K, Kawahata T, Otake T.
Screening of Chinese and Mongolian herbal drugs for anti-human immunodeficiency virus type 1 (HIV-1) activity.
Phytother Res.    impact factor:   .364
2002;  16(2): 186-9

13:  Nawawi A, Nakamura N, Meselhy MR, Hattori M, Kurokawa M, Shiraki K, Kashiwaba N, Ono M.
In vivo antiviral activity of Stephania cepharantha against herpes simplex virus type-1.
Phytother Res.    impact factor:   .364
2001;  15(6): 497-500

14:  Xie QM, Tang HF, Chen JQ, Bian RL.
Pharmacological actions of tetrandrine in inflammatory pulmonary diseases.
Acta Pharmacol Sin.    impact factor:   .196
2002;  23(12): 1107-13

15:  Rao MR.
Effects of tetrandrine on cardiac and vascular remodeling.
Acta Pharmacol Sin.    impact factor:   .196
2002;  23(12): 1075-85

16:  Wong TM, Wu S, Yu XC, Li HY.
Cardiovascular actions of Radix Stephaniae Tetrandrae: a comparison with its main component, tetrandrine.
Acta Pharmacol Sin.    impact factor:   .196
2000;  21(12): 1083-8

17:  Liang XC, Hagino N, Guo SS, Tsutsumi T, Kobayashi S.
Therapeutic efficacy of Stephania tetrandra S. Moore for treatment of neovascularization of retinal capillary (retinopathy) in diabetes--in vitro study.
Phytomedicine.    impact factor:   .185
2002;  9(5): 377-84

18:  Ebina T.
[Intratumoral administration of biological preparations--recommendation for integrative medicine]
Gan To Kagaku Ryoho.    impact factor:   0
2001;  28(11): 1515-8

19:  Li X, Zhang S, Qin L.
[Experimental study of analgesic effect of combined Radix Aconiti and Radix Stephaniae Tetrandrae]
Zhongguo Zhong Xi Yi Jie He Za Zhi.    impact factor:   0
2000;  20(3): 202-4

20:  Wang SR, Sun B, Ding GM.
[Animal experiments on meridian-reaching actions of traditional Chinese medicinal herbs]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1994;  19(8): 500-2, 512

21:  Yang YF, Zhao SX, Dong SS, Liu C.
[Dual-wavelength TLC densitometric determination of alkaloids in radix Stephaniae tetrandrae]
Zhong Yao Tong Bao.    impact factor:   0
1988;  13(12): 36-7, 59-60


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