Ingredient ID 208 
Chinese Pronunciation TAOERQI 
English Name Common Sinopodophyllum Root And Rhizome  
Latin Name Radix Et Rhizoma Sinopodophylli  
Aliases JiSuTai
Cancers Lymphoma
Identified Compounds

order by name

1. Alpha-peltatin

   C21H20O8   400.38
NSC# 24817 Activity (<1uM)

2. Picropodophyllin

   C22H22O8   414.41
NSC# 24818 Activity (<1uM)

3. Podophyllotoxin

   C22H22O8   414.41
NSC# 24818 Activity (<1uM)

4. Sikkimotoxin

   C23H26O8   430.45

5. 4'-demethylpodophyllotoxin Glucoside

   C27H30O13   562.52

6. Demethylpodophyllotoxin


7. Deoxypodophyllotoxin-i-beta-d-glucopyranoside Ester


8. Picropodophyllin Glucoside


9. Podophyllotoxin Glucoside

   C28H32O13   576.55

Recipes that contain

    Available references (order by impact factor):

    1:  Sugaya E, Ishige A, Sekiguchi K, Iizuka S, Ito K, Sugimoto A, Aburada M, Hosoya E.
    Inhibitory effect of TJ-960 (SK) on pentylenetetrazol-induced EEG power spectrum changes.
    Epilepsy Res.    impact factor:   2.193
    1988;  2(1): 27-31

    2:  Fukutake M, Miura N, Yamamoto M, Fukuda K, Iijima O, Ishikawa H, Kubo M, Okada M, Komatsu Y, Sasaki H, Wakabayashi K, Ishige A, Amagaya S.
    Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2 activity and azoxymethane-induced aberrant crypt foci development in rats.
    Cancer Lett.    impact factor:   1.518
    2000;  157(1): 9-14

    3:  Yang M, Zhang D, Liu J, Zheng J.
    A molecular marker that is specific to medicinal rhubarb based on chloroplast trnL/trnF sequences.
    Planta Med.    impact factor:   1.438
    2001;  67(8): 784-6

    4:  Fushimi H, Komatsu K, Namba T, Isobe M.
    Genetic heterogeneity of ribosomal RNA gene and matK gene in Panax notoginseng.
    Planta Med.    impact factor:   1.438
    2000;  66(7): 659-61

    5:  Sakamoto S, Mori T, Sawaki K, Kawachi Y, Kuwa K, Kudo H, Suzuki S, Sugiura Y, Kasahara N, Nagasawa H.
    Effects of kampo (Japanese herbal) medicine "sho-saiko-to" on DNA-synthesizing enzyme activity in 1,2-dimethylhydrazine-induced colonic carcinomas in rats.
    Planta Med.    impact factor:   1.438
    1993;  59(2): 152-4

    6:  Kinoshita K, Morikawa K, Fujita M, Natori S.
    Inhibitory effects of plant secondary metabolites on cytotoxic activity of polymorphonuclear leucocytes.
    Planta Med.    impact factor:   1.438
    1992;  58(2): 137-45

    7:  Suzuki F, Kobayashi M, Komatsu Y, Kato A, Pollard RB.
    Keishi-ka-kei-to, a traditional Chinese herbal medicine, inhibits pulmonary metastasis of B16 melanoma.
    Anticancer Res.    impact factor:   1.375
    1997;  17(2A): 873-8

    8:  Takase H, Inoue O, Saito Y, Yumioka E, Suzuki A.
    Roles of sulfhydryl compounds in the gastric mucosal protection of the herb drugs composing oren-gedoku-to (a traditional herbal medicine).
    Jpn J Pharmacol.    impact factor:   1.317
    1991;  56(4): 433-9

    9:  Takase H, Imanishi K, Miura O, Yumioka E, Watanabe H.
    Features of the anti-ulcer effects of Oren-gedoku-to (a traditional Chinese medicine) and its component herb drugs.
    Jpn J Pharmacol.    impact factor:   1.317
    1989;  49(3): 301-8

    10:  Li P, Kawachi H, Morioka T, Orikasa M, Oite T, Shi ZS, Shimizu F.
    Suppressive effects of sairei-to on monoclonal antibody 1-22-3-induced glomerulonephritis: analysis of effective components.
    Pathol Int.    impact factor:   .951
    1997;  47(7): 430-5

    11:  Fukutake M, Yokota S, Kawamura H, Iizuka A, Amagaya S, Fukuda K, Komatsu Y.
    Inhibitory effect of Coptidis Rhizoma and Scutellariae Radix on azoxymethane-induced aberrant crypt foci formation in rat colon.
    Biol Pharm Bull.    impact factor:   .844
    1998;  21(8): 814-7

    12:  Onishi Y, Yamaura T, Tauchi K, Sakamoto T, Tsukada K, Nunome S, Komatsu Y, Saiki I.
    Expression of the anti-metastatic effect induced by Juzen-taiho-to is based on the content of Shimotsu-to constituents.
    Biol Pharm Bull.    impact factor:   .844
    1998;  21(7): 761-5

    13:  Fushimi H, Komatsu K, Isobe M, Namba T.
    18S ribosomal RNA gene sequences of three Panax species and the corresponding ginseng drugs.
    Biol Pharm Bull.    impact factor:   .844
    1996;  19(11): 1530-2

    14:  Yasukawa K, Yu SY, Kakinuma S, Takido M.
    Inhibitory effect of rikkunshi-to, a traditional Chinese herbal prescription, on tumor promotion in two-stage carcinogenesis in mouse skin.
    Biol Pharm Bull.    impact factor:   .844
    1995;  18(5): 730-3

    15:  Tahara E, Satoh T, Toriizuka K, Nagai H, Nunome S, Shimada Y, Itoh T, Terasawa K, Saiki I.
    Effect of Shimotsu-to (a Kampo medicine, Si-Wu-Tang) and its constituents on triphasic skin reaction in passively sensitized mice.
    J Ethnopharmacol.    impact factor:   .687
    1999;  68(1-3): 219-28

    16:  Iijima K, Tanaka M, Toriizuka K, Cyong JC.
    Effects of Kampo medicines on the clearance of circulating immune complexes in mice.
    J Ethnopharmacol.    impact factor:   .687
    1994;  41(1-2): 77-83

    17:  Zhong XH, Zhou ZX, Li TS, Wang EQ, Shi WY, Chu SM.
    Anti-abortive effect of Radix scutellariae and Rhizoma atractylodis in mice.
    Am J Chin Med.    impact factor:   .583
    2002;  30(1): 109-17

    18:  Lin WC, Hsieh MT, Tsai HY, Chen CF.
    The pharmacological studies in central nervous system on the interaction of Taiwanese Veratri Formosani Rhizoma and Sophorae Radix.
    Am J Chin Med.    impact factor:   .583
    1984;  12(1-4): 124-35

    19:  Blaszczyk T, Krzyzanowska J, Lamer-Zarawska E.
    Screening for antimycotic properties of 56 traditional Chinese drugs.
    Phytother Res.    impact factor:   .364
    2000;  14(3): 210-2

    20:  Kase Y, Saitoh K, Makino B, Hashimoto K, Ishige A, Komatsu Y.
    Relationship between the antidiarrhoeal effects of Hange-Shashin-To and its active components.
    Phytother Res.    impact factor:   .364
    1999;  13(6): 468-73

    21:  Mantani N, Sakai S, Kogure T, Goto H, Shibahara N, Kita T, Shimada Y, Terasawa K.
    Herbal medicine and false-positive results on lymphocyte transformation test.
    Yakugaku Zasshi.    impact factor:   .238
    2002;  122(6): 399-402

    22:  Ozaki Y, Suga C, Yoshioka T, Morimoto T, Harada M.
    [Evaluation on equivalence of pharmacological properties between natural crude drugs and their cultured cells based on their components. Accelerative effect of lithospermi radix and inhibitory effect of coptidis rhizoma on proliferation of granulation tissue]
    Yakugaku Zasshi.    impact factor:   .238
    1990;  110(4): 268-72

    23:  Sato Y, Ohta S, Sakurai N, Shinoda M.
    [Studies on chemical protectors against radiation. XXVI. Protective effect of various extracts on crude drugs on skin injury induced by X-irradiation]
    Yakugaku Zasshi.    impact factor:   .238
    1989;  109(2): 113-8

    24:  Wang XJ, Feng P.
    Antioxidant activity of qizhu tang.
    Acta Pharmacol Sin.    impact factor:   .196
    2000;  21(12): 1141-4

    25:  Lee SK, Cho HK, Cho SH, Kim SS, Nahm DH, Park HS.
    Occupational asthma and rhinitis caused by multiple herbal agents in a pharmacist.
    Ann Allergy Asthma Immunol.    impact factor:   0
    2001;  86(4): 469-74

    26:  Xie F, Li X, Sun K, Chu Y, Cao H, Chen N, Wang W, Liu M, Liu W, Mao D.
    An experimental study on drugs for improving blood circulation and removing blood stasis in treating mild chronic hepatic damage.
    J Tradit Chin Med.    impact factor:   0
    2001;  21(3): 225-31

    27:  Wei F, Zou S, Young A, Dubner R, Ren K.
    Effects of four herbal extracts on adjuvant-induced inflammation and hyperalgesia in rats.
    J Altern Complement Med.    impact factor:   0
    1999;  5(5): 429-36

    28:  Su Z, Zeng Y, Zhou H, Wai J, Lian Y, Lu X, Liu L.
    [Preliminary study on chemical changes in the decocting process of radix et rhizoma Rhei]
    Zhongguo Zhong Yao Za Zhi.    impact factor:   0
    1999;  24(5): 291-2, 318

    29:  Cai L, Shu Y, Xie H.
    [Clinical and experimental study on the treatment of endometriosis with dan'e mixture]
    Zhongguo Zhong Xi Yi Jie He Za Zhi.    impact factor:   0
    1999;  19(3): 159-61

    30:  Wang D, Wang Z, Yu C.
    Endometriosis treated by the method of resolving blood stasis to eliminate obstruction in the lower-jiao.
    J Tradit Chin Med.    impact factor:   0
    1998;  18(1): 7-11

    31:  Sun Y, Hou S, Xue G.
    [Compatible leaching effect of Concha Ostreae and some commonly-used Chinese medicinal materials]
    Zhongguo Zhong Yao Za Zhi.    impact factor:   0
    1998;  23(9): 539-41, 576

    32:  Zhuo A, Luo L, Chen C, Huang W.
    Clinical observation of Chinese drugs in prevention of neonatal hyperbilirubinemia.
    J Tradit Chin Med.    impact factor:   0
    1997;  17(3): 174-7

    33:  Liu J, Zhai Y, Du H.
    [Quality criteria for bazhen shennongyin liquor]
    Zhongguo Zhong Yao Za Zhi.    impact factor:   0
    1997;  22(1): 28-31, 61

    34:  Zhang L, Yang L, Zheng X.
    A study of Helicobacterium pylori and prevention and treatment of chronic atrophic gastritis.
    J Tradit Chin Med.    impact factor:   0
    1997;  17(1): 3-9

    35:  Cyong JC.
    [New BRM from kampo-herbal medicine]
    Nippon Yakurigaku Zasshi.    impact factor:   0
    1997;  110 Suppl 1: 87P-92P

    36:  Tian J, Du H, Yang H, Liu X, Li Z.
    A clinical study on compound da huang (radix et Rhizoma rhei) preparations for improvement of senile persons' memory ability.
    J Tradit Chin Med.    impact factor:   0
    1997;  17(3): 168-73

    37:  Yu Z, Zhang G, Dai Y, Kou J, Dou C, Lu R.
    [Pharmacological study on the compatibility of cortex Cinnamomi with Halloysitum Rubrum]
    Zhongguo Zhong Yao Za Zhi.    impact factor:   0
    1997;  22(5): 309-12 inside back cover

    38:  Wu Y, Cao Y, Shi X, Shi Y.
    [Inhibitory effect of radix et rhizoma Rhei on the production of lipid peroxides (LPO) in mice liver]
    Zhongguo Zhong Yao Za Zhi.    impact factor:   0
    1996;  21(4): 240-2 inside backcover

    39:  Guan Y, Zhao S.
    Yishou jiangzhi (de-blood-lipid) tablets in the treatment of hyperlipemia.
    J Tradit Chin Med.    impact factor:   0
    1995;  15(3): 178-9

    40:  Li P, Fujio S.
    Effects of chai ling tang on proteinuria in rat models.
    J Tradit Chin Med.    impact factor:   0
    1995;  15(1): 48-52

    41:  Ikemoto K, Utsunomiya T, Ball MA, Kobayashi M, Pollard RB, Suzuki F.
    Protective effect of shigyaku-to, a traditional Chinese herbal medicine, on the infection of herpes simplex virus type 1 (HSV-1) in mice.
    Experientia.    impact factor:   0
    1994;  50(5): 456-60

    42:  Jin ZC, Qian J.
    [Inhibitory effects of fifteen kinds of Chinese herbal drugs, vegetables and chemicals on SOS response]
    Zhonghua Yu Fang Yi Xue Za Zhi.    impact factor:   0
    1994;  28(3): 147-50

    43:  Mi S.
    [A research for screening anti-hepatitis B virus drugs with the 2.2.15 cell line]
    Zhonghua Yi Xue Za Zhi.    impact factor:   0
    1992;  72(10): 612-5, 640

    44:  Shi YM, Wu QZ.
    [Idiopathic thrombocytopenic purpura in children treated with replenishing qi and tonifying kidney and the changes in thrombocyte aggregative function]
    Zhong Xi Yi Jie He Za Zhi.    impact factor:   0
    1991;  11(1): 14-6, 3

    45:  Sun W, Sha Z, Yan Z.
    [Identification of Chinese drugs by fluorescence spectrum]
    Zhongguo Zhong Yao Za Zhi.    impact factor:   0
    1991;  16(6): 326-8, 381

    46:  Wu L, Tong Y, Cheng L, Liu J.
    [Anti-inflammation and toxicity of radix Aconiti coreni and rhizoma Tyhon]
    Zhongguo Zhong Yao Za Zhi.    impact factor:   0
    1991;  16(10): 595-7, 639

    47:  Zhu X, Chu R.
    [A comparison of anti-arrhythmic effects of four kinds of rhizoma seu radix Nomopterygii]
    Zhongguo Zhong Yao Za Zhi.    impact factor:   0
    1990;  15(6): 366-8, 385

    48:  Liu Y, Gao X.
    [Circadian rhythms of mice to the catharsis of radix et rhizoma Rhei]
    Zhongguo Zhong Yao Za Zhi.    impact factor:   0
    1990;  15(12): 744-6, 766

    49:  Lin WS, Song XZ.
    [Clinical and experimental research on a kidney-tonifying prescription in preventing and treating children's hearing-loss induced by aminoglycoside antibiotic ototoxicity]
    Zhong Xi Yi Jie He Za Zhi.    impact factor:   0
    1989;  9(7): 402-4, 388

    50:  Wang SQ, Du XR, Lu HW, Wang TL, Li H.
    Experimental and clinical studies of "Shen Yan Ling" in treatment of chronic glomerulonephritis.
    J Tradit Chin Med.    impact factor:   0
    1989;  9(2): 132-4

    51:  Zhou Z.
    [Application and mechanism of radix et rhizoma rhei in treating diseases of the digestive system]
    Zhongguo Zhong Yao Za Zhi.    impact factor:   0
    1989;  14(8): 501-3, 512

    52:  Hu SK, Zhou XJ, Zeng XL, Dou ZL, Li XH, Wu J.
    Morphological changes induced by radix et rhizoma rhei in Wistar rats.
    J Tradit Chin Med.    impact factor:   0
    1986;  6(1): 37-42

    53:  Zhao SY.
    [Clinical studies on 2 acute diseases of the digestive tract treated with 2 kinds of radix et rhizoma Rhei]
    Zhong Yao Tong Bao.    impact factor:   0
    1986;  11(3): 58-60

    54:  Jiang WJ.
    [Processing of radix et rhizoma Rhei]
    Zhong Yao Tong Bao.    impact factor:   0
    1986;  11(12): 3-7

    55:  Aburada M, Takeda S, Ito E, Nakamura M, Hosoya E.
    Protective effects of juzentaihoto, dried decoctum of 10 Chinese herbs mixture, upon the adverse effects of mitomycin C in mice.
    J Pharmacobiodyn.    impact factor:   0
    1983;  6(12): 1000-4

    56:  Okabe S, Takeuchi K, Ikenishi H, Ohmi F, Takaoka A.
    [Effects of SM powder, a combined herbal preparation for stomach diseases, on gastric secretion and acute gastro-duodenal lesions in rats]
    Nippon Yakurigaku Zasshi.    impact factor:   0
    1983;  81(4): 285-94

    57:  Kimura M, Suzuki J.
    The pattern of action of blended Chinese traditional medicines to glucose tolerance curves in genetically diabetic KK-CAy mice.
    J Pharmacobiodyn.    impact factor:   0
    1981;  4(12): 907-15


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