Ingredient ID 232 
Chinese Pronunciation HUANGQIN 
English Name Baikal Skullcap Root  
Latin Name Radix Scutellariae  
Aliases TiaoQin
ShuWeiQin
TuJinChaGen  
Cancers Lung
Liver
Intestine
Rectum
Nasopharynx
Stomach
Leukemia  
Identified Compounds
24

order by name

1. Baicalein

   C15H10O5   270.24
  ID:544

2. Baicalin

   C21H18O11   446.36
  ID:546

3. Carthamidin

   C15H12O6   288.25
  ID:907

4. Chrysin

   C15H10O4   254.24
NSC# 407436 Activity (but inactive >10uM)
  ID:1043

5. Dihydrooroxylin A

   C16H14O5   286.28
  ID:1761

6. 5,8-dihydroxy-6,7-dimethoxyflavone

   C17H14O6   314.29
  ID:1794

7. 5,6-dihydroxy-7-o-glucoside-flavone

   C21H20O10   432.38
  ID:1806

8. 5,2'-dihydroxy-6,7,8-trimethoxyflavone

   C18H16O7   344.32
  ID:1847

9. Skullcapflavone Ii

   C13H22O4   242.31
  ID:1897

10. 7-methoxybaicalein

   C16H12O5   284.27
  ID:4188

11. Scutellarin

   C21H18O12   462.36
  ID:5778

12. Beta-sitosterol

   C29H50O   414.71
  ID:5884

13. Skullcapflavone I

   C17H14O6   314.29
  ID:5896

14. Stigmasterol

   C29H48O   412.7
  ID:6006

15. 5,8,2'-trihydroxy-6,7-dimethoxyflavone

   C17H14O7   330.29
  ID:6392

16. 5,2',5'-trihydroxy-6,7,8-trirnethoxy Flavone

   C18H16O9   376.31
  ID:6419

17. Wogonin

   C16H12O5   284.27
  ID:6710

18. Wogonoside

   C22H20O11   460.39
  ID:6711

19. 7-methoxynorwogonin

   C17H14O5   298.29
  ID:6881

20. Neobaicalein

   C19H18O8   374.34
  ID:7494

21. Oroxylin A

   C16H12O5   284.27
  ID:7532

22. Kogan-ebanain

   C19H18O8   374.34
  ID:7867

23. Isocarthamidin

   C15H12O6   288.25
  ID:7868

24. Oroxylin A-glucuronide

   C23H22O10   458.41
  ID:8523

 
Recipes that contain
HUANGQIN
  1. 2      KangAiPian
  2. 72      FangFengXinYiTang
  3. 73      ShengJinJieDuYin
  4. 74      ZiCaoGenTang
  5. 130      PangGuangAiFang
  6. 145      SanHuangHaoLianTang
  7. 150      DangGuiLuHuiWan
  8. 153      KangBaiHeJi
  9. 164      LiangGenLianHuaTang
 

Available references (order by impact factor):

1:  Liu XF, Liu ML, Iyanagi T, Legesse K, Lee TD, Chen SA.
Inhibition of rat liver NAD(P)H:quinone acceptor oxidoreductase (DT-diaphorase) by flavonoids isolated from the Chinese herb scutellariae radix (Huang Qin).
Mol Pharmacol.    impact factor:   5.465
1990;  37(6): 911-5

2:  Hui KM, Huen MS, Wang HY, Zheng H, Sigel E, Baur R, Ren H, Li ZW, Wong JT, Xue H.
Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi.
Biochem Pharmacol.    impact factor:   2.755
2002;  64(9): 1415-24

3:  Chen S, Hwang J, Deng PS.
Inhibition of NAD(P)H:quinone acceptor oxidoreductase by flavones: a structure-activity study.
Arch Biochem Biophys.    impact factor:   2.386
1993;  302(1): 72-7

4:  Ikemoto S, Sugimura K, Yoshida N, Yasumoto R, Wada S, Yamamoto K, Kishimoto T.
Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines.
Urology.    impact factor:   2.197
2000;  55(6): 951-5

5:  Sakai Y, Nagase H, Ose Y, Sato T, Kawai M, Mizuno M.
Effects of medicinal plant extracts from Chinese herbal medicines on the mutagenic activity of benzo[a]pyrene.
Mutat Res.    impact factor:   2.107
1988;  206(3): 327-34

6:  Hwang YS, Shin CY, Huh Y, Ryu JH.
Hwangryun-Hae-Dok-tang (Huanglian-Jie-Du-Tang) extract and its constituents reduce ischemia-reperfusion brain injury and neutrophil infiltration in rats.
Life Sci.    impact factor:   1.774
2002;  71(18): 2105-17

7:  Ueng YF, Shyu CC, Lin YL, Park SS, Liao JF, Chen CF.
Effects of baicalein and wogonin on drug-metabolizing enzymes in C57BL/6J mice.
Life Sci.    impact factor:   1.774
2000;  67(18): 2189-200

8:  Kimura Y, Okuda H, Ogita Z.
Effects of flavonoids isolated from scutellariae radix on fibrinolytic system induced by trypsin in human umbilical vein endothelial cells.
J Nat Prod.    impact factor:   1.652
1997;  60(6): 598-601

9:  Fukutake M, Miura N, Yamamoto M, Fukuda K, Iijima O, Ishikawa H, Kubo M, Okada M, Komatsu Y, Sasaki H, Wakabayashi K, Ishige A, Amagaya S.
Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2 activity and azoxymethane-induced aberrant crypt foci development in rats.
Cancer Lett.    impact factor:   1.518
2000;  157(1): 9-14

10:  Kimura Y, Matsushita N, Yokoi-Hayashi K, Okuda H.
Effects of baicalein isolated from Scutellaria baicalensis Radix on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells.
Planta Med.    impact factor:   1.438
2001;  67(4): 331-4

11:  Kimura Y, Okuda H, Arichi S.
Studies on scutellariae radix; XIII. Effects of various flavonoids on arachidonate metabolism in leukocytes.
Planta Med.    impact factor:   1.438
1985;  (2): 132-6

12:  Ryu SH, Ahn BZ, Pack MY.
The cytotoxic principle of Scutellariae radix against L1210 cell.
Planta Med.    impact factor:   1.438
1985;  (4): 355

13:  Ryu SH, Ahn BZ, Pack MY.
The cytotoxic principle of Scutellariae radix against L1210 cell.
Planta Med.    impact factor:   1.438
1985;  (5): 462

14:  Kimura Y, Okuda H, Taira Z, Shoji N, Takemoto T, Arichi S.
Studies on Scutellariae radix. IX. New component inhibiting lipid peroxidation in rat liver.
Planta Med.    impact factor:   1.438
1984;  50(4): 290-5

15:  Kubo M, Kimura Y, Odani T, Tani T, Namba K.
Studies on Scutellariae radix. Part II: The antibacterial substance.
Planta Med.    impact factor:   1.438
1981;  43(2): 194-201

16:  Nakamura T, Kuriyama M, Kosuge E, Ishihara K, Ito K.
Effects of saiboku-to (TJ-96) on the production of platelet-activating factor in human neutrophils.
Ann N Y Acad Sci.    impact factor:   1.381
1993;  685: 572-9

17:  Takase H, Inoue O, Saito Y, Yumioka E, Suzuki A.
Roles of sulfhydryl compounds in the gastric mucosal protection of the herb drugs composing oren-gedoku-to (a traditional herbal medicine).
Jpn J Pharmacol.    impact factor:   1.317
1991;  56(4): 433-9

18:  Takase H, Imanishi K, Miura O, Yumioka E, Watanabe H.
Features of the anti-ulcer effects of Oren-gedoku-to (a traditional Chinese medicine) and its component herb drugs.
Jpn J Pharmacol.    impact factor:   1.317
1989;  49(3): 301-8

19:  Park HJ, Lee YW, Park HH, Lee YS, Kwon IB, Yu JH.
Induction of quinone reductase by a methanol extract of Scutellaria baicalensis and its flavonoids in murine Hepa 1c1c7 cells.
Eur J Cancer Prev.    impact factor:   1.287
1998;  7(6): 465-71

20:  Kim SH, Kim YH, Han SS, Roh JK.
Teratogenicity study of Scutellariae Radix in rats.
Reprod Toxicol.    impact factor:   1.277
1993;  7(1): 73-9

21:  Akao T, Kawabata K, Yanagisawa E, Ishihara K, Mizuhara Y, Wakui Y, Sakashita Y, Kobashi K.
Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form.
J Pharm Pharmacol.    impact factor:   1.195
2000;  52(12): 1563-8

22:  Kyo R, Nakahata N, Sakakibara I, Kubo M, Ohizumi Y.
Baicalin and baicalein, constituents of an important medicinal plant, inhibit intracellular Ca2+ elevation by reducing phospholipase C activity in C6 rat glioma cells.
J Pharm Pharmacol.    impact factor:   1.195
1998;  50(10): 1179-82

23:  Kimura Y, Yokoi K, Matsushita N, Okuda H.
Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells.
J Pharm Pharmacol.    impact factor:   1.195
1997;  49(8): 816-22

24:  Matsuura K, Kawakita T, Nakai S, Saito Y, Suzuki A, Nomoto K.
Role of B-lymphocytes in the immunopharmacological effects of a traditional Chinese medicine, xiao-chai-hu-tang (shosaiko-to).
Int J Immunopharmacol.    impact factor:   1.142
1993;  15(2): 237-43

25:  Xie LH, Wang X, Basnet P, Matsunaga N, Yamaji S, Yang DY, Cai SQ, Tani T.
Evaluation of variation of acteoside and three major flavonoids in wild and cultivated Scutellaria baicalensis roots by micellar electrokinetic chromatography.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
2002;  50(7): 896-9

26:  Li C, Homma M, Ohkura N, Oka K.
Stereochemistry and putative origins of flavanones found in post-administration urine of the traditional Chinese remedies shosaiko-to and daisaiko-to.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
1998;  46(5): 807-11

27:  Abe K, Inoue O, Yumioka E.
Biliary excretion of metabolites of baicalin and baicalein in rats.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
1990;  38(1): 209-11

28:  Kubo M, Matsuda H, Tani T, Arichi S, Kimura Y, Okuda H.
Studies on Scutellariae radix. XII. Anti-thrombic actions of various flavonoids from Scutellariae radix.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
1985;  33(6): 2411-5

29:  Kubo M, Matsuda H, Tanaka M, Kimura Y, Okuda H, Higashino M, Tani T, Namba K, Arichi S.
Studies on Scutellariae radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellariae radix.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
1984;  32(7): 2724-9

30:  Kimura Y, Kubo M, Kusaka K, Tani T, Higashino M, Arichi S, Okuda H.
Studies on Scutellariae radix. V. Effects on ethanol-induced hyperlipemia and lipolysis in isolated fat cells.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
1982;  30(1): 219-22

31:  Kimura Y, Okuda H, Tani T, Arichi S.
Studies on Scutellariae radix. VI. Effects of flavanone compounds on lipid peroxidation in rat liver.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
1982;  30(5): 1792-5

32:  Kimura Y, Kubo M, Tani T, Arichi S, Ohminami H, Okuda H.
Studies on Scutellariae radix. III. Effects on lipid metabolism in serum, liver and fat cells of rats.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
1981;  29(8): 2308-12

33:  Kimuya Y, Kubo M, Tani T, Arichi S, Okuda H.
Studies on Scutellariae Radix. IV. Effects on lipid peroxidation in rat liver.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
1981;  29(9): 2610-7

34:  Kim JY, Lee S, Kim DH, Kim BR, Park R, Lee BM.
Effects of flavonoids isolated from Scutellariae radix on cytochrome P-450 activities in human liver microsomes.
J Toxicol Environ Health A.    impact factor:   1.009
2002;  65(5-6): 373-81

35:  Lai MY, Hsiu SL, Chen CC, Hou YC, Chao PD.
Urinary Pharmacokinetics of Baicalein, Wogonin and Their Glycosides after Oral Administration of Scutellariae Radix in Humans.
Biol Pharm Bull.    impact factor:   .844
2003;  26(1): 79-83

36:  Zuo F, Zhou ZM, Yan MZ, Liu ML, Xiong YL, Zhang Q, Song HY, Ye WH.
Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal flora.
Biol Pharm Bull.    impact factor:   .844
2002;  25(5): 558-63

37:  Sanae F, Komatsu Y, Chisaki K, Kido T, Ishige A, Hayashi H.
Effects of San'o-shashin-to and the constituent herbal medicines on theophylline-induced increase in arterial blood pressure of rats.
Biol Pharm Bull.    impact factor:   .844
2001;  24(10): 1137-41

38:  Okawa M, Kinjo J, Nohara T, Ono M.
DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity of flavonoids obtained from some medicinal plants.
Biol Pharm Bull.    impact factor:   .844
2001;  24(10): 1202-5

39:  Kyo R, Nakahata N, Kodama Y, Nakai Y, Kubo M, Ohizumi Y.
Antagonism of saikosaponin-induced prostaglandin E2 release by baicalein in C6 rat glioma cells.
Biol Pharm Bull.    impact factor:   .844
1999;  22(12): 1385-7

40:  Kase Y, Saitoh K, Ishige A, Komatsu Y.
Mechanisms by which Hange-shashin-to reduces prostaglandin E2 levels.
Biol Pharm Bull.    impact factor:   .844
1998;  21(12): 1277-81

41:  Fukutake M, Yokota S, Kawamura H, Iizuka A, Amagaya S, Fukuda K, Komatsu Y.
Inhibitory effect of Coptidis Rhizoma and Scutellariae Radix on azoxymethane-induced aberrant crypt foci formation in rat colon.
Biol Pharm Bull.    impact factor:   .844
1998;  21(8): 814-7

42:  Kyo R, Nakahata N, Sakakibara I, Kubo M, Ohizumi Y.
Effects of Sho-saiko-to, San'o-shashin-to and Scutellariae Radix on intracellular Ca2+ mobilization in C6 rat glioma cells.
Biol Pharm Bull.    impact factor:   .844
1998;  21(10): 1067-71

43:  Yamaoka Y, Kawakita T, Kaneko M, Nomoto K.
A polysaccharide fraction of Zizyphi fructus in augmenting natural killer activity by oral administration.
Biol Pharm Bull.    impact factor:   .844
1996;  19(7): 936-9

44:  Nemoto Y, Satoh K, Toriizuka K, Hirai Y, Tobe T, Sakagami H, Nakashima H, Ida Y.
Cytotoxic and radical scavenging activity of blended herbal extracts.
In Vivo.    impact factor:   .794
2002;  16(5): 327-32

45:  Wang HH, Liao JF, Chen CF.
Anticonvulsant effect of water extract of Scutellariae radix in mice.
J Ethnopharmacol.    impact factor:   .687
2000;  73(1-2): 185-90

46:  Kimura Y, Matsushita N, Okuda H.
Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells.
J Ethnopharmacol.    impact factor:   .687
1997;  57(1): 63-7

47:  Watanabe H, Kobayashi T, Tomii M, Sekiguchi Y, Uchida K, Aoki T, Cyong JC.
Effects of Kampo herbal medicine on plasma melatonin concentration in patients.
Am J Chin Med.    impact factor:   .583
2002;  30(1): 65-71

48:  Zhong XH, Zhou ZX, Li TS, Wang EQ, Shi WY, Chu SM.
Anti-abortive effect of Radix scutellariae and Rhizoma atractylodis in mice.
Am J Chin Med.    impact factor:   .583
2002;  30(1): 109-17

49:  Chen JH, Ho HO, Yen KY, Yan LL.
Hepatoprotection by "dangqui-long-hwei-wan" in male mice.
Am J Chin Med.    impact factor:   .583
2000;  28(1): 115-21

50:  Nakahata N, Kutsuwa M, Kyo R, Kubo M, Hayashi K, Ohizumi Y.
Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells.
Am J Chin Med.    impact factor:   .583
1998;  26(3-4): 311-23

51:  Kang JJ, Chen YC, Kuo WC, Chen T, Cheng YW, Kuo ML, Ueng TH.
Modulation of microsomal cytochrome P450 by Scutellariae Radix and Gentianae scabrae Radix in rat liver.
Am J Chin Med.    impact factor:   .583
1996;  24(1): 19-29

52:  Nagaki Y, Hayasaka S, Kadoi C, Nakamura N, Hayasaka Y.
Effects of scutellariae radix extract and its components (baicalein, baicalin, and wogonin) on the experimental elevation of aqueous flare in pigmented rabbits.
Jpn J Ophthalmol.    impact factor:   .479
2001;  45(3): 216-20

53:  Lian Z, Fujimoto J, Yokoyama Y, Niwa K, Tamaya T.
Herbal complex suppresses telomerase activity in chemo-endocrine resistant cancer cell lines.
Eur J Gynaecol Oncol.    impact factor:   .397
2001;  22(5): 347-9

54:  Kase Y, Saitoh K, Makino B, Hashimoto K, Ishige A, Komatsu Y.
Relationship between the antidiarrhoeal effects of Hange-Shashin-To and its active components.
Phytother Res.    impact factor:   .364
1999;  13(6): 468-73

55:  Kumazawa N, Ohta S, Ishizuka O, Sakurai N, Kamogawa A, Shinoda M.
[Protective effects of various methanol extracts of crude drugs on experimental hepatic injury induced by carbon tetrachloride in rats]
Yakugaku Zasshi.    impact factor:   .238
1990;  110(12): 950-7

56:  Shurygin AY, Bezzubov NV, Ignatova EA, Nikolaev SM, Viktorov IV.
Baikal Skullcap Extract Stimulates Neurite Growth in Cultures of Rat Dorsal Root Ganglia.
Bull Exp Biol Med.    impact factor:   0
2002;  134(1): 47-49

57:  Hong SJ, Fong JC, Hwang JH.
Effects of crude drugs on lipolysis in differentiated 3T3-L1 adipocytes.
Kaohsiung J Med Sci.    impact factor:   0
2002;  18(4): 157-63

58:  Martin J, Dusek J.
[In Process Citation]
Ceska Slov Farm.    impact factor:   0
2002;  51(6): 277-83

59:  Jia Y, Yang Y, Zhou Y, Song Y, Liu L, Song J, Wang X, Zhong L, Yu X.
Differentiation of rat bone marrow stromal cells into neuron induced by baicalin.
Zhonghua Yi Xue Za Zhi.    impact factor:   0
2002;  82(19): 1337-41

60:  Kubo M, Song Q, Tang F.
[Historical investigation of dentifrice in China]
Yakushigaku Zasshi.    impact factor:   0
2001;  36(2): 130-5

61:  Hong SJ, Fong JC, Hwang JH.
Effects of crude drugs on glucose uptake in 3T3-L1 adipocytes.
Kaohsiung J Med Sci.    impact factor:   0
2000;  16(9): 445-51

62:  Duan TX, Ma CH, Lun LH, Hou YX.
[Determination of baicalin in banxiaxiexintang decoction different combinations of the by PR-HPLC]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
2000;  25(2): 99-100

63:  Qi L, Zhou R, Wang YF, Zhu YC.
Study of major flavonoids in crude Scutellariae Radix by micellar electrokinetic capillary chromatography.
J Capillary Electrophor.    impact factor:   0
1998;  5(5-6): 181-4

64:  Sun Y, Hou S, Xue G.
[Compatible leaching effect of Concha Ostreae and some commonly-used Chinese medicinal materials]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1998;  23(9): 539-41, 576

65:  He G, Jiang M, Feng Y, Li D.
[Chemical changes of compatibility for shaoyao decoction]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1998;  23(7): 432-4, inside back cover

66:  Zhuo A, Luo L, Chen C, Huang W.
Clinical observation of Chinese drugs in prevention of neonatal hyperbilirubinemia.
J Tradit Chin Med.    impact factor:   0
1997;  17(3): 174-7

67:  Zheng C, Ji L, Chen G, Chen J, Tang Z.
[Quality standard of tanre kesou granules]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1996;  21(6): 348-50, 383

68:  Chen F, Guo Y, Meng X, Zhang S.
[Identification of chaihu guizhi ganjiang decoction by three dimensional HPLC]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1995;  20(4): 223-4, 253

69:  Liao JF, Jan YM, Huang SY, Wang HH, Yu LL, Chen CF.
Evaluation with receptor binding assay on the water extracts of ten CNS-active Chinese herbal drugs.
Proc Natl Sci Counc Repub China B.    impact factor:   0
1995;  19(3): 151-8

70:  Hubik J, Spilkova J.
[Herbal drugs in Kampo preparations]
Cesk Farm.    impact factor:   0
1993;  42(2): 65-7

71:  Wakui Y, Yanagisawa E, Ishibashi E, Matsuzaki Y, Takeda S, Sasaki H, Aburada M, Oyama T.
Determination of baicalin and baicalein in rat plasma by high-performance liquid chromatography with electrochemical detection.
J Chromatogr.    impact factor:   0
1992;  575(1): 131-6

72:  Huang L, Liu J, Li D, Wang Z, Ye W, Cai B, Liu M, Li M.
[A study on components and compound prescription of huangqin decoction]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1991;  16(3): 177-81, back cover

73:  Su W.
[Application of cluster analysis to the classification of Radix scutellariae]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1991;  16(10): 579-81, 638

74:  Minematsu S, Taki M, Watanabe M, Takahashi M, Wakui Y, Ishihara K, Takeda S, Fujii Y.
[Effects of Shosaiko-to-go-keishikashakuyaku-to (TJ-960) on the valproic acid induced anomalies of rat fetuses]
Nippon Yakurigaku Zasshi.    impact factor:   0
1990;  96(5): 265-73

75:  Huang L, Ye W, Cai B, Li D, Liu J, Liu M.
[A preliminary study on the pharmacology of the compound prescription huangqin tang and its component drugs]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1990;  15(2): 115-7, 128

 

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