Ingredient ID 234 
Chinese Pronunciation HUANGLIAN 
English Name Coptis Root  
Latin Name Rhizoma Coptidis  
Aliases TuHuangLian
WeiLian
ChuanLian
JiZhuaLian  
Cancers Liver
Esophagus  
Identified Compounds
19

order by name

1. Berberine

   C20H18NO4   336.37
NSC# 150446 Activity (<10uM)
NSC# 163088 Activity (<10uM)
  ID:617

2. Columbamine

   C20H21NO5   355.38
  ID:1186

3. Coptisine

   C19H14NO4   320.32
NSC# 119754 Activity (<1uM)
  ID:1229

4. Ferulic Acid

   C10H10O4   194.19
  ID:2356

5. Neprotin

   C20H20NO4   338.38
NSC# 93137 Activity (but inactive >10uM)
  ID:3638

6. Escholine

   C20H24NO4   342.41
  ID:4057

7. Obaculactone

   C26H30O8   470.52
NSC# 36508 Activity (but inactive >10uM)
  ID:4795

8. Obacunone

   C26H30O7   454.52
  ID:4797

9. Palmatine

   C21H22NO4   352.41
NSC# 209407 Activity (but inactive >10uM)
  ID:4947

10. Worenine

   C20H16NO4   334.35
  ID:6713

11. Berberasfine

      

12. Epiberberine

   C20H18NO4   336.37
  ID:7204

13. Furulic Acid

      

14. Groenlandicine

   C19H16NO4   322.34
  ID:7294

15. 3',4'dihydroxyphenethyl Alcohol-1-o-beta-d-glucopyranoside

   C14H20O8   316.3
  ID:8035

16. 4-o-feruloyl-d-quinic Acid

   C16H26O12   530.48
  ID:8066

17. Berberastine

   C20H18NO5   352.36
  ID:8116

18. Gentisic Acid-5-o-beta-d-glucopyranoside

   C13H16O9   316.26
  ID:8244

19. Jatrorrhizine

   C20H20ClNO4   373.83
  ID:8294

 
Recipes that contain
HUANGLIAN
  1. 2      KangAiPian
  2. 3      KangAiTang
  3. 8      ErFenWan
  4. 36      ShanJiaKuShenTang
  5. 140      JuZaoWan
  6. 150      DangGuiLuHuiWan
  7. 153      KangBaiHeJi
  8. 166      LuGanShiHu
  9. 205      KangAiPian
  10. 206      KangAiTang
  11. 206      KangAiTang
  12. 212      ErFenWan
  13. 219      FuFanLaoShaTang(San)
  14. 221      KangAiWan
  15. 226      XiYiKangAiYiHaoSan
  16. 228      ShiGuanAiFang
  17. 237      LianPuTang
  18. 259      WeiAiFang
  19. 267      ShanJiaKuShenTang
  20. 271      KangAiWan
  21. 325      FuFangBanZhiLianTang
  22. 335      GongJingWan(Fen)
  23. 351      TuoDuWan
  24. 352      YuHuangWan
  25. 355      LongSheXiaoLiuWan
  26. 362      HeYueSan
  27. 421      JuZaoWan
  28. 438      KangBaiHeJi
  29. 465      FuFangLuGanShiHu
  30. 485      LuanCaoAiFang
  31. 500      WeiAiFangIII
  32. 502      LongSheXiaoLiuWan
  33. 521      GanAiCanKaoFangII
 

Available references (order by impact factor):

1:  Iizuka N, Hazama S, Yoshimura K, Yoshino S, Tangoku A, Miyamoto K, Okita K, Oka M.
Anticachectic effects of the natural herb Coptidis rhizoma and berberine on mice bearing colon 26/clone 20 adenocarcinoma.
Int J Cancer.    impact factor:   3.545
2002;  99(2): 286-91

2:  Miura N, Yamamoto M, Ueki T, Kitani T, Fukuda K, Komatsu Y.
Inhibition of thymocyte apoptosis by berberine.
Biochem Pharmacol.    impact factor:   2.755
1997;  53(9): 1315-22

3:  Hwang YS, Shin CY, Huh Y, Ryu JH.
Hwangryun-Hae-Dok-tang (Huanglian-Jie-Du-Tang) extract and its constituents reduce ischemia-reperfusion brain injury and neutrophil infiltration in rats.
Life Sci.    impact factor:   1.774
2002;  71(18): 2105-17

4:  Chan CP, But PP, Ho JW.
Induction of rcl, a novel growth-related gene by coptidis rhizoma in rat H4IIE cells.
Life Sci.    impact factor:   1.774
2002;  70(14): 1691-9

5:  Hwang JM, Wang CJ, Chou FP, Tseng TH, Hsieh YS, Lin WL, Chu CY.
Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver.
Arch Toxicol.    impact factor:   1.683
2002;  76(11): 664-70

6:  Lee HS.
Rat Lens Aldose Reductase Inhibitory Activities of Coptis japonica Root-Derived Isoquinoline Alkaloids.
J Agric Food Chem.    impact factor:   1.56
2002;  50(24): 7013-6

7:  Kim JP, Jung MY, Kim JP, Kim SY.
Antiphotooxidative activity of protoberberines derived from Coptis japonica makino in the chlorophyll-sensitized photooxidation of oil.
J Agric Food Chem.    impact factor:   1.56
2000;  48(4): 1058-63

8:  Ahn YJ, Park SJ, Lee SG, Shin SC, Choi DH.
Cordycepin: selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp.
J Agric Food Chem.    impact factor:   1.56
2000;  48(7): 2744-8

9:  Chae SH, Jeong IH, Choi DH, Oh JW, Ahn YJ.
Growth-inhibiting effects of Coptis japonica root-derived isoquinoline alkaloids on human intestinal bacteria.
J Agric Food Chem.    impact factor:   1.56
1999;  47(3): 934-8

10:  Mitani N, Murakami K, Yamaura T, Ikeda T, Saiki I.
Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma.
Cancer Lett.    impact factor:   1.518
2001;  165(1): 35-42

11:  Iizuka N, Miyamoto K, Hazama S, Yoshino S, Yoshimura K, Okita K, Fukumoto T, Yamamoto S, Tangoku A, Oka M.
Anticachectic effects of Coptidis rhizoma, an anti-inflammatory herb, on esophageal cancer cells that produce interleukin 6.
Cancer Lett.    impact factor:   1.518
2000;  158(1): 35-41

12:  Fukutake M, Miura N, Yamamoto M, Fukuda K, Iijima O, Ishikawa H, Kubo M, Okada M, Komatsu Y, Sasaki H, Wakabayashi K, Ishige A, Amagaya S.
Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2 activity and azoxymethane-induced aberrant crypt foci development in rats.
Cancer Lett.    impact factor:   1.518
2000;  157(1): 9-14

13:  Iizuka N, Miyamoto K, Okita K, Tangoku A, Hayashi H, Yosino S, Abe T, Morioka T, Hazama S, Oka M.
Inhibitory effect of Coptidis Rhizoma and berberine on the proliferation of human esophageal cancer cell lines.
Cancer Lett.    impact factor:   1.518
2000;  148(1): 19-25

14:  Lee MK, Kim HS.
Inhibitory effects of protoberberine alkaloids from the roots of Coptis japonica on catecholamine biosynthesis in PC12 cells.
Planta Med.    impact factor:   1.438
1996;  62(1): 31-4

15:  Hattori T, Furuta K, Nagao T, Nagamatsu T, Ito M, Suzuki Y.
Studies on the antinephritic effect of plant components (4): Reduction of protein excretion by berberine and coptisine in rats with original-type anti-GBM nephritis.
Jpn J Pharmacol.    impact factor:   1.317
1992;  59(2): 159-69

16:  Takase H, Inoue O, Saito Y, Yumioka E, Suzuki A.
Roles of sulfhydryl compounds in the gastric mucosal protection of the herb drugs composing oren-gedoku-to (a traditional herbal medicine).
Jpn J Pharmacol.    impact factor:   1.317
1991;  56(4): 433-9

17:  Hattori T, Ito M, Suzuki Y.
Studies on antinephritic effect of TJ-8014, syo-saiko-to-kyo-shyokyo-ka-ouren-bukuryou (5): Effects on puromycin aminonucleoside nephrosis and its mechanisms.
Jpn J Pharmacol.    impact factor:   1.317
1991;  56(4): 465-73

18:  Takase H, Imanishi K, Miura O, Yumioka E, Watanabe H.
Features of the anti-ulcer effects of Oren-gedoku-to (a traditional Chinese medicine) and its component herb drugs.
Jpn J Pharmacol.    impact factor:   1.317
1989;  49(3): 301-8

19:  Ji SG, Chai YF, Zhang GQ, Wu YT, Liang DS, Xu ZM.
Determination of berberine in Rhizoma coptidis and its preparations by non-aqueous capillary electrophoresis.
Biomed Chromatogr.    impact factor:   1.145
1999;  13(7): 439-41

20:  Shigeta K, Ootaki K, Tatemoto H, Nakanishi T, Inada A, Muto N.
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids.
Biosci Biotechnol Biochem.    impact factor:   1.039
2002;  66(11): 2491-4

21:  Park IK, Lee HS, Lee SG, Park JD, Ahn YJ.
Antifeeding activity of isoquinoline alkaloids identified in Coptis japonica roots against Hyphantria cunea (Lepidoptera: Arctiidae) and Agelastica coerulea (Coleoptera: Galerucinae).
J Econ Entomol.    impact factor:   .909
2000;  93(2): 331-5

22:  Kim YS, Jung EA, Shin JE, Chang JC, Yang HK, Kim NJ, Cho KH, Bae HS, Moon SK, Kim DH.
Daio-Orengedokuto inhibits HMG-CoA reductase and pancreatic lipase.
Biol Pharm Bull.    impact factor:   .844
2002;  25(11): 1442-5

23:  Sanae F, Komatsu Y, Chisaki K, Kido T, Ishige A, Hayashi H.
Effects of San'o-shashin-to and the constituent herbal medicines on theophylline-induced increase in arterial blood pressure of rats.
Biol Pharm Bull.    impact factor:   .844
2001;  24(10): 1137-41

24:  Hirano H, Osawa E, Yamaoka Y, Yokoi T.
Gastric-mucous membrane protection activity of coptisine derivatives.
Biol Pharm Bull.    impact factor:   .844
2001;  24(11): 1277-81

25:  Kase Y, Saitoh K, Ishige A, Komatsu Y.
Mechanisms by which Hange-shashin-to reduces prostaglandin E2 levels.
Biol Pharm Bull.    impact factor:   .844
1998;  21(12): 1277-81

26:  Bae EA, Han MJ, Kim NJ, Kim DH.
Anti-Helicobacter pylori activity of herbal medicines.
Biol Pharm Bull.    impact factor:   .844
1998;  21(9): 990-2

27:  Fukutake M, Yokota S, Kawamura H, Iizuka A, Amagaya S, Fukuda K, Komatsu Y.
Inhibitory effect of Coptidis Rhizoma and Scutellariae Radix on azoxymethane-induced aberrant crypt foci formation in rat colon.
Biol Pharm Bull.    impact factor:   .844
1998;  21(8): 814-7

28:  Hakamatsuka T, Tanaka N.
Screening for bioactive compounds targeting the cellular signal transduction pathway using an RT-PCR-based bioassay system.
Biol Pharm Bull.    impact factor:   .844
1997;  20(4): 464-6

29:  Nemoto Y, Satoh K, Toriizuka K, Hirai Y, Tobe T, Sakagami H, Nakashima H, Ida Y.
Cytotoxic and radical scavenging activity of blended herbal extracts.
In Vivo.    impact factor:   .794
2002;  16(5): 327-32

30:  Nakamoto K, Sadamori S, Hamada T.
Effects of crude drugs and berberine hydrochloride on the activities of fungi.
J Prosthet Dent.    impact factor:   .767
1990;  64(6): 691-4

31:  Umeda M, Amagaya S, Ogihara Y.
Effects of certain herbal medicines on the biotransformation of arachidonic acid: a new pharmacological testing method using serum.
J Ethnopharmacol.    impact factor:   .687
1988;  23(1): 91-8

32:  Wang YY, Sheu JI, Wang WK.
Alterations of pulse by Chinese herb medicine.
Am J Chin Med.    impact factor:   .583
1992;  20(2): 181-90

33:  Cho JY, Park J, Yoo ES, Yoshikawa K, Baik KU, Lee J, Park MH.
Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor-alpha production in lipopolysaccharide-stimulated RAW264.7 cells.
Arch Pharm Res.    impact factor:   .382
1998;  21(1): 12-6

34:  Kase Y, Saitoh K, Makino B, Hashimoto K, Ishige A, Komatsu Y.
Relationship between the antidiarrhoeal effects of Hange-Shashin-To and its active components.
Phytother Res.    impact factor:   .364
1999;  13(6): 468-73

35:  Satoh K, Nagai F, Seto T, Yamauchi H.
[The effects of kampo-formulation and the constituting crude drugs, prescribed for the treatment of peptic ulcer on H,K-ATPase activity]
Yakugaku Zasshi.    impact factor:   .238
2001;  121(2): 173-8

36:  Sasaki K, Sudo T, Kurusu T, Kiuchi T, Yoshizaki F.
[The mechanism of alteration of monoamine metabolism in brain regions in marble burying behavior-isolated housing mice and effect of oren-gedoku-to on this alteration]
Yakugaku Zasshi.    impact factor:   .238
2000;  120(6): 559-67

37:  Namba T, Sekiya K, Toshinal A, Kadota S, Hatanaka T, Katayama K, Koizumi T.
[Study on baths with crude drug. II.: the effects of coptidis rhizoma extracts as skin permeation enhancer]
Yakugaku Zasshi.    impact factor:   .238
1995;  115(8): 618-25

38:  Ozaki Y, Suzuki H, Satake M.
[Comparative studies on concentration of berberine in plasma after oral administration of coptidis rhizoma extract, its cultured cells extract, and combined use of these extracts and glycyrrhizae radix extract in rats]
Yakugaku Zasshi.    impact factor:   .238
1993;  113(1): 63-9

39:  Tanaka T, Metori K, Mineo S, Hirotani M, Furuya T, Matsumoto H, Satoh T, Kobayashi S.
[Studies on collagenase inhibitors. IV. Inhibitors of bacterial collagenase in Coptidis rhizoma]
Yakugaku Zasshi.    impact factor:   .238
1991;  111(9): 538-41

40:  Ozaki Y, Suga C, Yoshioka T, Morimoto T, Harada M.
[Evaluation on equivalence of pharmacological properties between natural crude drugs and their cultured cells based on their components. Accelerative effect of lithospermi radix and inhibitory effect of coptidis rhizoma on proliferation of granulation tissue]
Yakugaku Zasshi.    impact factor:   .238
1990;  110(4): 268-72

41:  Mikage M, Ushiyama T, Namba T.
[Fundamental studies on the evaluation of crude drugs. X. Electron microscopic analysis of crude drugs. (2). On the distribution of alkaloids in Coptidis rhizoma and Phellodendri cortex]
Yakugaku Zasshi.    impact factor:   .238
1987;  107(9): 690-3

42:  Namba T, Mikage M, Ushiyama T.
[Fundamental studies on the evaluation of crude drugs. VI. Electron microscopic analysis of crude drugs. (1). Determination of berberine in Coptidis rhizoma (author's transl)]
Yakugaku Zasshi.    impact factor:   .238
1982;  102(1): 56-62

43:  Ishikawa O, Hashimoto T, Nakajima T, Tanaka O, Itokawa H.
[Application of high-speed liquid chromatography to analysis of crude drugs: Quaternary alkaloids of Coptidis Rhizoma and Phellodendri Cortex (author's transl)]
Yakugaku Zasshi.    impact factor:   .238
1978;  98(7): 976-9

44:  Hattori T, Kamiya N, Inoue M, Hayakawa M.
[Analytical studies on the active constituents in crude drugs. II. Determination of berberine in Coptidis rhizoma by high performance liquid chromatography (author's transl)]
Yakugaku Zasshi.    impact factor:   .238
1977;  97(12): 1305-8

45:  Hattori T, Inoue M, Hayakawa M.
[Analytical studies on the active constituents in crude drugs. I. Determination of berberine in Coptidis Rhizoma with tetrabromophenolphthalein ethyl ester using thin-layer chromatography (author's transl)]
Yakugaku Zasshi.    impact factor:   .238
1977;  97(11): 1263-6

46:  Yokozawa T, Chen CP, Tanaka T.
Direct scavenging of nitric oxide by traditional crude drugs.
Phytomedicine.    impact factor:   .185
2000;  6(6): 453-63

47:  Deng Y, Yang L, Qiu X, Dong Y.
[Study on the quality standards for xianghe suppository]
Zhong Yao Cai.    impact factor:   0
2001;  24(9): 672-3

48:  Duan TX, Ma CH, Lun LH, Hou YX.
[Determination of baicalin in banxiaxiexintang decoction different combinations of the by PR-HPLC]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
2000;  25(2): 99-100

49:  Kang C, Wen LY, Ding ZB, Guo R, Zhu XS.
[Studies on separation and identification of Rhizoma coptidis brugs based on microemulsion thin-layer chromatography]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
2000;  25(5): 262-5

50:  Hu JP, Takahashi N, Yamada T.
Coptidis Rhizoma inhibits growth and proteases of oral bacteria.
Oral Dis.    impact factor:   0
2000;  6(5): 297-302

51:  Zhou H, Wei L, Yang D.
[Determination of alkaloids in Coptis-Cinnamomum compatibility by capillary electrophoresis]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1999;  24(5): 308-10, 320

52:  Lee HS, Eom YE, Eom DO.
Narrowbore high performance liquid chromatography of berberine and palmatine in crude drugs and pharmaceuticals with ion-pair extraction using cobalt thiocyanate reagent.
J Pharm Biomed Anal.    impact factor:   0
1999;  21(1): 59-63

53:  Kawamoto M, Mikage M.
[Herbological studies of Coptidis rhizoma (Part 2): on the old Japanese name of Coptis japonica makino.]
Yakushigaku Zasshi.    impact factor:   0
1999;  34(1): 35-41

54:  He G, Jiang M, Feng Y, Li D.
[Chemical changes of compatibility for shaoyao decoction]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1998;  23(7): 432-4, inside back cover

55:  Zhang L, Chen Z, Ma X, Zhao Y.
[Effect of different nitrogen concentrations on the growth and contents of berberine in rhizome of Coptis chinensis Franch]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1998;  23(7): 394-6, 446-7

56:  Liao J, Li PP, Wu CJ.
[Screening new photosensitizers from Chinese medicinal herbs and searching for herbal photodynamic killing effects on human stomach cancer cells]
Zhongguo Zhong Xi Yi Jie He Za Zhi.    impact factor:   0
1997;  17(12): 726-9

57:  Zhang L, Yang L, Zheng X.
A study of Helicobacterium pylori and prevention and treatment of chronic atrophic gastritis.
J Tradit Chin Med.    impact factor:   0
1997;  17(1): 3-9

58:  Higaki S, Nakamura M, Morohashi M, Hasegawa Y, Yamagishi T.
Activity of eleven kampo formulations and eight kampo crude drugs against Propionibacterium acnes isolated from acne patients: retrospective evaluation in 1990 and 1995.
J Dermatol.    impact factor:   0
1996;  23(12): 871-5

59:  Higaki S, Nakamura M, Morohashi M, Hasegawa Y, Yamagishi T.
Anti-lipase activity of Kampo formulations, coptidis rhizoma and its alkaloids against Propionibacterium acnes.
J Dermatol.    impact factor:   0
1996;  23(5): 310-4

60:  Higaki S, Hasegawa Y, Morohashi M, Takayoshi Y.
The correlation of Kampo formulations and their ingredients on anti-bacterial activities against Propionibacterium acnes.
J Dermatol.    impact factor:   0
1995;  22(1): 4-9

61:  Chang MX, Yao CY, Liu XP, Ma Z, Liu JX, Huang DY.
[Bacteriostasis of rhizoma Coptidis combined with trimethoprim (TMPO)]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1994;  19(12): 748-9, 764

62:  Wang YM, Zhang JZ, Zhu FY, Liu W, Yang Y, Fang QM, Wang Y.
[Effects of compatible using of fructurs Evodiae on the main chemical components of rhizoma Coptidis]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1994;  19(2): 115-8, 128

63:  Hubik J, Spilkova J.
[Herbal drugs in Kampo preparations]
Cesk Farm.    impact factor:   0
1993;  42(2): 65-7

64:  Kaneda Y, Tanaka T, Saw T.
Effects of berberine, a plant alkaloid, on the growth of anaerobic protozoa in axenic culture.
Tokai J Exp Clin Med.    impact factor:   0
1990;  15(6): 417-23

65:  Li R, Gong P, Wang C.
[Comparison of constituents and alkaloid contents in rhizoma Coptidis before and after processing]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1990;  15(11): 663-6, 702

66:  Higaki S, Hasegawa Y, Morohashi M, Sakamoto K, Yamagishi T.
[The influence of coptidis rhizoma to lipase activity of Propionibacterium acnes]
Nippon Hifuka Gakkai Zasshi.    impact factor:   0
1990;  100(8): 883-6

67:  Lin SL, Zhao LH, Wang YM, Dong SS, An DK.
[Determination of berberine in Angong Niuhuang Wan by HPLC]
Yao Xue Xue Bao.    impact factor:   0
1989;  24(1): 48-52

68:  Yang SH.
[Effects of coptidis rhizoma and decoction of artemisia rheum gardeniae on the reserve albumin binding capacity in serum of Chinese newborn infants]
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi.    impact factor:   0
1988;  29(6): 391-6

69:  Wang TZ, Fang XP, Zhang H, Xiong RX, Xie CK.
[Medicinal plants of rhizoma Coptidis]
Zhong Yao Tong Bao.    impact factor:   0
1988;  13(1): 7-8, 61

70:  Qiu XX, Wu CY, Chen BL.
[Analysis of berberine-type alkaloids in rhizoma Coptidis and Chinese patent medicines by micellar chromatography]
Yao Xue Xue Bao.    impact factor:   0
1986;  21(6): 458-65

71:  Zhu M.
[Quality evaluation of Chinese traditional drug, "huang-lian", rhizoma Coptidis]
Zhong Yao Tong Bao.    impact factor:   0
1984;  9(2): 63-4

72:  Okabe S, Takeuchi K, Ikenishi H, Ohmi F, Takaoka A.
[Effects of SM powder, a combined herbal preparation for stomach diseases, on gastric secretion and acute gastro-duodenal lesions in rats]
Nippon Yakurigaku Zasshi.    impact factor:   0
1983;  81(4): 285-94

73:  Han Y.
[Remarks on Chinese materia medica (12)--Coptis root, a drug for clearing heat and drying wetness]
Zhong Yao Tong Bao.    impact factor:   0
1983;  8(4): 44-6

74:  Yamahara J.
[Behavioral pharmacology of berberine-type alkaloids. (1) Central depressive action of Coptidis rhizoma and its constituents]
Nippon Yakurigaku Zasshi.    impact factor:   0
1976;  72(7): 899-908

 

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