Ingredient ID 235 
Chinese Pronunciation HUANGBO 
English Name Amur Cork-tree Bark  
Latin Name Cortex Phellodendri  
Aliases GuanHuangBo  
Cancers Bladder
Identified Compounds

order by name

1. Amurensin

   C26H30O12   534.51

2. Berberine

   C20H18NO4   336.37
NSC# 150446 Activity (<10uM)
NSC# 163088 Activity (<10uM)

3. Campesterol

   C28H48O   400.68

4. N-candicine

   C11H18NO   180.27

5. Dictamnolide


6. Quercetin-3-o-galactoside

   C21H20O12   464.38

7. Neprotin

   C20H20NO4   338.38
NSC# 93137 Activity (but inactive >10uM)

8. Lumicaeruleic Acid


9. Escholine

   C20H24NO4   342.41

10. Menisperine

   C21H26NO4   356.44
NSC# 90558 Activity (<1uM)

11. Obaculactone

   C26H30O8   470.52
NSC# 36508 Activity (but inactive >10uM)

12. Obacunoic Acid

   C26H32O8   472.53

13. Obacunone

   C26H30O7   454.52

14. Palmatine

   C21H22NO4   352.41
NSC# 209407 Activity (but inactive >10uM)

15. Phellamurin

   C26H30O11   518.51

16. Phellatin

   C26H30O12   534.51

17. Phellavin

   C26H32O12   536.53

18. Phellodendrine

   C20H24NO4   342.41

19. Beta-sitosterol

   C29H50O   414.71

20. 7-dehydrostigmasterol

   C29H46O   410.68

21. Jatrorrhizine

   C20H20ClNO4   373.83

Recipes that contain
  1. 2      KangAiPian
  2. 79      GongJingAiFang
  3. 104      LianBoTang
  4. 126      PangGuangTang
  5. 127      ErJiTang
  6. 135      PangGuangAiFangWu
  7. 145      SanHuangHaoLianTang
  8. 149      SanCaiFengShuiDan
  9. 150      DangGuiLuHuiWan
  10. 205      KangAiPian
  11. 226      XiYiKangAiYiHaoSan
  12. 271      KangAiWan

Available references (order by impact factor):

1:  Yuan LM, Zi M, Ai P, Chen XX, Li ZY, Fu RN, Zhang TY.
Versatile two-phase solvent system for alkaloid separation by high-speed counter-current chromatography.
J Chromatogr A.    impact factor:   2.52
2001;  927(1-2): 91-6

2:  Hwang YS, Shin CY, Huh Y, Ryu JH.
Hwangryun-Hae-Dok-tang (Huanglian-Jie-Du-Tang) extract and its constituents reduce ischemia-reperfusion brain injury and neutrophil infiltration in rats.
Life Sci.    impact factor:   1.774
2002;  71(18): 2105-17

3:  Park JI, Shim JK, Do JW, Kim SY, Seo EK, Kwon HJ, Lee TK, Kim JK, Choi DY, Kim CH.
Immune-stimulating properties of polysaccharides from Phellodendri cortex (Hwangbek).
Glycoconj J.    impact factor:   1.757
1999;  16(3): 247-52

4:  Mitani N, Murakami K, Yamaura T, Ikeda T, Saiki I.
Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma.
Cancer Lett.    impact factor:   1.518
2001;  165(1): 35-42

5:  Mori H, Fuchigami M, Inoue N, Nagai H, Koda A, Nishioka I, Meguro K.
Principle of the bark of Phellodendron amurense to suppress the cellular immune response: effect of phellodendrine on cellular and humoral immune responses.
Planta Med.    impact factor:   1.438
1995;  61(1): 45-9

6:  Mori H, Fuchigami M, Inoue N, Nagai H, Koda A, Nishioka I.
Principle of the bark of Phellodendron amurense to suppress the cellular immune response.
Planta Med.    impact factor:   1.438
1994;  60(5): 445-9

7:  Takase H, Inoue O, Saito Y, Yumioka E, Suzuki A.
Roles of sulfhydryl compounds in the gastric mucosal protection of the herb drugs composing oren-gedoku-to (a traditional herbal medicine).
Jpn J Pharmacol.    impact factor:   1.317
1991;  56(4): 433-9

8:  Takase H, Imanishi K, Miura O, Yumioka E, Watanabe H.
Features of the anti-ulcer effects of Oren-gedoku-to (a traditional Chinese medicine) and its component herb drugs.
Jpn J Pharmacol.    impact factor:   1.317
1989;  49(3): 301-8

9:  Wada K, Yagi M, Matsumura A, Sasaki K, Sakata M, Haga M.
Isolation of limonin and obacunone from phellodendri cortex shorten the sleeping time induced in mice by alpha-chloralose-urethane.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
1990;  38(8): 2332-4

10:  Nakamoto K, Sadamori S, Hamada T.
Effects of crude drugs and berberine hydrochloride on the activities of fungi.
J Prosthet Dent.    impact factor:   .767
1990;  64(6): 691-4

11:  Uchiyama T, Kamikawa H, Ogita Z.
[Anti-ulcer effect of extract from phellodendri cortex]
Yakugaku Zasshi.    impact factor:   .238
1989;  109(9): 672-6

12:  Mikage M, Ushiyama T, Namba T.
[Fundamental studies on the evaluation of crude drugs. X. Electron microscopic analysis of crude drugs. (2). On the distribution of alkaloids in Coptidis rhizoma and Phellodendri cortex]
Yakugaku Zasshi.    impact factor:   .238
1987;  107(9): 690-3

13:  Ishikawa O, Hashimoto T, Nakajima T, Tanaka O, Itokawa H.
[Application of high-speed liquid chromatography to analysis of crude drugs: Quaternary alkaloids of Coptidis Rhizoma and Phellodendri Cortex (author's transl)]
Yakugaku Zasshi.    impact factor:   .238
1978;  98(7): 976-9

14:  Okada J, Kawashima Y.
[Studies on the extraction of plant constituents. 3. Extraction of berberine from Phellodendri cortex]
Yakugaku Zasshi.    impact factor:   .238
1969;  89(4): 558-64

15:  Hong SJ, Fong JC, Hwang JH.
Effects of crude drugs on lipolysis in differentiated 3T3-L1 adipocytes.
Kaohsiung J Med Sci.    impact factor:   0
2002;  18(4): 157-63

16:  Zhou C, Yu Z, Li R, Tian Z.
The principle and technique of using Chinese drugs in the treatment of hypertension.
J Tradit Chin Med.    impact factor:   0
2001;  21(1): 7-11

17:  Hong SJ, Fong JC, Hwang JH.
Effects of crude drugs on glucose uptake in 3T3-L1 adipocytes.
Kaohsiung J Med Sci.    impact factor:   0
2000;  16(9): 445-51

18:  Lee HS, Eom YE, Eom DO.
Narrowbore high performance liquid chromatography of berberine and palmatine in crude drugs and pharmaceuticals with ion-pair extraction using cobalt thiocyanate reagent.
J Pharm Biomed Anal.    impact factor:   0
1999;  21(1): 59-63

19:  Zhang X, Zhang Z, Xu X, Wang Y.
[Comparison of semi-bionic extraction and water extraction in extraction of chemical constituents from processed cortex Phellodendri]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1999;  24(10): 600-2, 638

20:  Wu C, Zhou Z, He Y.
[Identification and determination of Shenbaiye]
Hua Xi Yi Ke Da Xue Xue Bao.    impact factor:   0
1998;  29(3): 334-7

21:  Liao J, Li PP, Wu CJ.
[Screening new photosensitizers from Chinese medicinal herbs and searching for herbal photodynamic killing effects on human stomach cancer cells]
Zhongguo Zhong Xi Yi Jie He Za Zhi.    impact factor:   0
1997;  17(12): 726-9

22:  Higaki S, Nakamura M, Morohashi M, Hasegawa Y, Yamagishi T.
Activity of eleven kampo formulations and eight kampo crude drugs against Propionibacterium acnes isolated from acne patients: retrospective evaluation in 1990 and 1995.
J Dermatol.    impact factor:   0
1996;  23(12): 871-5

23:  Wang Y, Zhu H, Wang D, Wang K.
[RP-HPLC determination of berberine in cortex Phellodendri]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1995;  20(7): 425-6, 448-9

24:  Higaki S, Hasegawa Y, Morohashi M, Takayoshi Y.
The correlation of Kampo formulations and their ingredients on anti-bacterial activities against Propionibacterium acnes.
J Dermatol.    impact factor:   0
1995;  22(1): 4-9

25:  Hubik J, Spilkova J.
[Herbal drugs in Kampo preparations]
Cesk Farm.    impact factor:   0
1993;  42(2): 65-7


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