Ingredient ID 31 
Chinese Pronunciation MAQIANZI 
English Name Nux Vomica  
Latin Name Semen Strychni  
Aliases FanMuBie
Cancers Esophagus
Identified Compounds

order by ID

1. 16-hydroxy-alpha-colubrine

   C22H24N2O4   380.44

2. 16-hydroxy-beta-colubrine

   C22H24N2O4   380.44

3. 2-hydroxy-3-methoxystrychnine

   C22H24N2O4   380.44

4. Alpha-colubrine

   C22H24N2O3   364.44

5. Alpha-colubrine


6. Beta-colubrine

   C22H24N2O3   364.44
NSC# 72862 Activity (<1uM)

7. Brucine

   C23H26N2O4   394.47

8. Cycloartenyl Palmitate


9. Icajine

   C22H24N2O3   364.44

10. Isobrucine

   C23H26N2O4   394.47

11. Isobrucine N-oxide

   C23H26N2O5   410.47

12. Isostrychnine

   C21H24N2O2   336.43

13. Isostrychnine N-oxide

   C21H24N2O3   352.43

14. Loganin

   C17H26O10   390.38

15. Novacine

   C24H28N2O5   424.49

16. Pseudobrucine

   C23H26N2O5   410.47
NSC# 99794 Activity (but inactive >10uM)

17. Pseudostrychnine

   C21H22N2O3   350.42
NSC# 99792 Activity (but inactive >10uM)

18. Strychnine

   C21H22N2O2   334.42

19. Vomicine

   C22H24N2O4   380.44

Recipes that contain
  1. 19      LiQiJiangNiTang
  2. 118      HuangDuLiangGenTang
  3. 140      JuZaoWan
  4. 144      PiQianSan
  5. 166      LuGanShiHu
  6. 185      KanAiYiHaoFenJi
  7. 233      QuanYangWan
  8. 235      LiangGenTang
  9. 258      GongJianWan
  10. 284      GanAiFang
  11. 284      GanAiFang
  12. 289      LongDanXieGanTang
  13. 351      TuoDuWan
  14. 378      AiLiuGao
  15. 395      HuangDuLiangGenTang
  16. 417      ShiAiGao
  17. 427      PiQianSan
  18. 445      MaHuangTang
  19. 465      FuFangLuGanShiHu
  20. 519      GanAiFangVI

Available references (order by impact factor):

1:  Yuan LM, Zi M, Ai P, Chen XX, Li ZY, Fu RN, Zhang TY.
Versatile two-phase solvent system for alkaloid separation by high-speed counter-current chromatography.
J Chromatogr A.    impact factor:   2.52
2001;  927(1-2): 91-6

2:  Biala RG, Tits M, Penelle J, Frederich M, Brandt V V, Prosperi C, Llabres G, Angenot L.
Strychnochrysine, a New Bisindole Alkaloid from the Roots of Strychnos nux-vomica1
J Nat Prod.    impact factor:   1.652
1998;  61(1): 139-41

3:  Adinolfi M, Corsaro MM, Lanzetta R, Parrilli M, Folkard G, Grant W, Sutherland J.
Composition of the coagulant polysaccharide fraction from Strychnos potatorum seeds.
Carbohydr Res.    impact factor:   1.606
1994;  263(1): 103-10

4:  Zong YY, Che CT.
Determination of strychnine and brucine by capillary zone electrophoresis.
Planta Med.    impact factor:   1.438
1995;  61(5): 456-8

5:  Sefcovic P, Dubravkova L, Torto FG.
[Alkaloids from the leaves of strychnos nux vomica L.]
Planta Med.    impact factor:   1.438
1968;  16(2): 143-6

6:  Dennis R.
The rapid estimation of strychnine in tincture of nux vomica BP by high-performance liquid chromatography.
J Pharm Pharmacol.    impact factor:   1.195
1984;  36(5): 332-3

7:  Chen W, Liu L, Li X, Li J, Ji S, Zhang G, Chai Y.
Separation and determination of strychnine and brucine in Strychnos nux-vomica L. and its preparation by capillary zone electrophoresis.
Biomed Chromatogr.    impact factor:   1.145
2000;  14(8): 541-3

8:  Cai BC, Hattori M, Namba T.
Processing of nux vomica. II. Changes in alkaloid composition of the seeds of Strychnos nux-vomica on traditional drug-processing.
Chem Pharm Bull (Tokyo).    impact factor:   1.117
1990;  38(5): 1295-8

9:  Corsaro MM, Giudicianni I, Lanzetta R, Marciano CE, Monaco P, Parrilli M.
Polysaccharides from seeds of Strychnos species.
Phytochemistry.    impact factor:   1.106
1995;  39(6): 1377-80

10:  Chan TY.
Herbal medicine causing likely strychnine poisoning.
Hum Exp Toxicol.    impact factor:   1.063
2002;  21(8): 467-8

11:  Cai B, Nagasawa T, Kadota S, Hattori M, Namba T, Kuraishi Y.
Processing of nux vomica. VII. Antinociceptive effects of crude alkaloids from the processed and unprocessed seeds of Strychnos nux-vomica in mice.
Biol Pharm Bull.    impact factor:   .844
1996;  19(1): 127-31

12:  Shoba FG, Thomas M.
Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea.
J Ethnopharmacol.    impact factor:   .687
2001;  76(1): 73-6

13:  Rahlfs VW, Mossinger P.
[Treatment of irritable colon. A multicenter placebo-controlled double-blind study in general practice]
Arzneimittelforschung.    impact factor:   .671
1976;  26(12): 2230-4

14:  Friese KH, Feuchter U, Moeller H.
[Homeopathic treatment of adenoid vegetations. Results of a prospective, randomized double-blind study]
HNO.    impact factor:   .486
1997;  45(8): 618-24

15:  Metwally AM.
A paper chromatographic method for the estimation of strychnine in nux-vomica seed.
Pharmazie.    impact factor:   .446
1978;  33(11): 763-4

16:  Metwally AM.
A further approach to quantitative determinations by thin layer chromatography.
Pharmazie.    impact factor:   .446
1975;  30(2): 92-4

17:  Hayakawa J, Noda N, Yamada S, Uno K.
[Studies on physical and chemical quality evaluation of crude drug preparation. II. Analysis of pharmaceutical preparations including nux vomica extracts by high performance liquid chromatography]
Yakugaku Zasshi.    impact factor:   .238
1984;  104(1): 57-61

18:  Okada J, Kawashima Y.
[Studies on the extraction of plant constituents. IV. Extraction of strychinine and brucine from strychni semen]
Yakugaku Zasshi.    impact factor:   .238
1969;  89(10): 1345-51

19:  Tripathi YB, Chaurasia S.
Interaction of Strychnos nux-vomica-products and iron: with reference to lipid peroxidation.
Phytomedicine.    impact factor:   .185
2000;  7(6): 523-8

20:  Wong S, Tsui S, Kwan S.
Analysis of proprietary Chinese medicines for the presence of toxic ingredients by LC/MS/MS.
J Pharm Biomed Anal.    impact factor:   0
2002;  30(1): 161-70

21:  Sukul NC, Ghosh S, Sinhababu SP, Sukul A.
Strychnos nux-vomica extract and its ultra-high dilution reduce voluntary ethanol intake in rats.
J Altern Complement Med.    impact factor:   0
2001;  7(2): 187-93

22:  Shi Y, Zhang H, Du X, Zhang M, Yin Y, Zhou C, Song S, Fu X, Li S, Liu Y, Li H, Li X, Wu X, Zhu Y.
A double blind observation for therapeutic effects of the tong luo kai bi tablets on rheumatoid arthritis.
J Tradit Chin Med.    impact factor:   0
1999;  19(3): 166-72

23:  Chen X, Gui X, Xie Z.
[Influence of processing methods on alkaloid, toxicity and effect of Strychnos nux-vomica L.]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1998;  23(3): 151-3, 191

24:  Cai BC, Wang TS, Kurokawa M, Shiraki K, Hattori M.
Cytotoxicities of alkaloids from processed and unprocessed seeds of Strychnos nux-vomica.
Zhongguo Yao Li Xue Bao.    impact factor:   0
1998;  19(5): 425-8

25:  Shi J, Sun L, Jing X.
[Protein analysis of 6 crude drugs and their processed products by polyacrylamide gel electrophoresis technique]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1995;  20(9): 533-5, 574

26:  He Y, Wu M, Cai B, Zheng P, Yuan Z.
[Influence of different processing methods of four alkaloid contents in Strychnos nux-vomica L.]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1995;  20(2): 84-6, 126

27:  Cai BC, He YW, Ding HF, Ma C, Wu H.
[Determination of alkaloids and comparison of the acute toxicity of differently processed products of the seeds of Strychnos nux-vomica L.]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1994;  19(10): 598-600, 638

28:  Wu H, Cai BC, Zheng PX, Zhao CZ, Yuan ZR.
[Effect of processing on the alkaloids in Strychnos nux-vomica L.]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1994;  19(5): 277-9, 319

29:  Ye DJ.
[Study on the history of the processing of semen Strychni]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1993;  18(5): 259-62

30:  Yang XW, Yan ZK.
[Studies on the chemical constituents of alkaloids in seeds of Strychnos nux-vomica L.]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1993;  18(12): 739-40, 763-4

31:  Cai BC, Yang WX, Zhu WY, Lu JC, Ye DJ.
[Effect of processing on the extraction of alkaloids from Strychnos]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1993;  18(1): 23-4, 62

32:  Gao H, Sun W, Sha Z.
[Quantitative determination of strychnine and brucine in semen Strychni and its preparations by gas chromatography]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1990;  15(11): 670-1, 703

33:  Zhao DK, Xu HQ, Liu JS.
[Main pharmacological roles and clinical curative effect of sanbi rebao]
Zhong Xi Yi Jie He Za Zhi.    impact factor:   0
1990;  10(9): 545-6, 518

34:  Lu M, Li M, Hao S, Zhang D.
[Simultaneous determination of brucine and strychnine in semen Strychni by dual wavelength spectrophotometry and studies on processing principles of semen Strychni]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1990;  15(12): 722-5, 764

35:  Sha DZ, Dou JH, Li F, Tang Y.
[Studies on the relation of alkaloids in semen Strychni and its processing]
Zhongguo Zhong Yao Za Zhi.    impact factor:   0
1989;  14(1): 22-4, 62

36:  Gaudy D, Puech A.
[A new T.L.C. method: bidimensional with currents opposed at 180 degrees. Application to the identification of alkaloids in medicinal preparations of nux vomica]
J Pharm Belg.    impact factor:   0
1987;  42(4): 251-8

37:  Gaudy D, Puech A.
[Quality control of galenic preparations of nux vomica: proposal for a new method of extracting and assaying strychnine and brucine]
Ann Pharm Fr.    impact factor:   0
1986;  44(1): 49-54

38:  Liu DX.
[Mitotic effect of radix codonopsis pilosulae, radix astragali and semen strychni on human lymphocytes]
Zhong Yao Tong Bao.    impact factor:   0
1985;  10(3): 40-2

39:  Korany MA, Seif El-Din AA.
First derivative spectrophotometric determination of strychnine and brucine in nux vomica liquid extract.
J Assoc Off Anal Chem.    impact factor:   0
1984;  67(1): 138-41

40:  Villar A, Rios JL, Gonzalez JM.
[Application of high performance liquid chromatography to the analysis of Nux vomica alkaloids: a comparison with volumetric methods]
Ann Pharm Fr.    impact factor:   0
1984;  42(2): 149-54

41:  Gong LG.
[Studies on the processing method of Strychnos nux-vomica]
Zhong Yao Tong Bao.    impact factor:   0
1984;  9(2): 67-9

42:  Puech A, Gaudy D, Duru C, Jacob M.
[Concerning the dosage of the alkaloids in preparation base on the Strychnos Nux vomica L. A study of the official methods french Pharmacopea 9th edition addendum number 30 (1980)]
Ann Pharm Fr.    impact factor:   0
1982;  40(2): 167-72

43:  El-Masry S, Wahbi AA.
Spectrophotometric determination of strychnine and brucine in liquid galenicals.
J Assoc Off Anal Chem.    impact factor:   0
1978;  61(1): 65-7

44:  Karawya MS, Hifnawy MS, Dahawi HS.
Colorimetric assay of strychnine and brucine in nux vomica.
J Assoc Off Anal Chem.    impact factor:   0
1975;  58(1): 85-7

45:  Galeffi C, Delle Monache EM, Marini-Bettolo GB.
Strychnos alkaloids. XXVII. Separation and characterisation of isostrychnine in Strychnos nux vomica L. seeds.
J Chromatogr.    impact factor:   0
1974;  88(2): 416-8

46:  Karawya MS, Ghourab MG.
Assay of strychnine in nux vomica galenicals and in formulations.
J Assoc Off Anal Chem.    impact factor:   0
1972;  55(1): 177-9

47:  Wisniewski W, Pietura A.
[Colorimetric determination of strychnine and brucine in Semen Strychni and galenic preparations by chromatographic separation]
Acta Pol Pharm.    impact factor:   0
1971;  28(4): 391-3

48:  Wisniewski W, Pietura A.
[Colorimetric method of determination of content of the total amount of strychnine and brucine in the seeds of strychnos nux vomica (Semen Strychni) and in galenic preparations]
Acta Pol Pharm.    impact factor:   0
1970;  27(3): 279-84

49:  Delle Monache F, Gelabert de Brovetto A, Cor E, Marini-Bettolo GB.
The separation of the minor alkaloids of Strychnos nux vomica L.
J Chromatogr.    impact factor:   0
1968;  32(1): 178-9

50:  Chen ZC, Chang SL, Tai JL.
[Studies on the analysis of alkaloidal extract preparations. II. Determination of Nux Vomica preparations by thin-layer chromatography-catalytic polarographic method]
Yao Xue Xue Bao.    impact factor:   0
1966;  13(2): 131-6


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