Ingredient ID 451 
Chinese Pronunciation HEQINGHUA 
English Name Japanese Hylomecon Herb  
Latin Name Herba Hylomeconis Japonicae  
Aliases GuaiLingQi
Cancers Nourish  
Identified Compounds

order by name

1. Allocryptopine

   C21H23NO5   369.41

2. Berberine

   C20H18NO4   336.37
NSC# 150446 Activity (<10uM)
NSC# 163088 Activity (<10uM)

3. Chelerythrine

   C21H18NO4   348.38
NSC# 36405 Activity (<1uM)
NSC# 76023 Activity (<10uM)

4. Diphyline

   C20H19NO5   353.37
NSC# 406034 Activity (<1uM)

5. Chelilutine

   C22H20NO5   378.4

6. Coptisine

   C19H14NO4   320.32
NSC# 119754 Activity (<1uM)

7. Cryptopine

   C21H23NO5   369.41

8. Protopine

   C20H19NO5   353.37

9. Sanguinarine

   C20H14NO4   332.33

10. Stylopine

   C19H17NO4   323.35

11. (-)-tetrahydroberberine

   C20H21NO4   339.39
NSC# 36351 Activity (but inactive >10uM)
NSC# 94918 Activity (but inactive >10uM)

Recipes that contain

    Available references (order by impact factor):

    1:  Yamashiki M, Nishimura A, Suzuki H, Sakaguchi S, Kosaka Y.
    Effects of the Japanese herbal medicine "Sho-saiko-to" (TJ-9) on in vitro interleukin-10 production by peripheral blood mononuclear cells of patients with chronic hepatitis C.
    Hepatology.    impact factor:   7.344
    1997;  25(6): 1390-7

    2:  Nagasaka K, Kurokawa M, Imakita M, Terasawa K, Shiraki K.
    Efficacy of kakkon-to, a traditional herb medicine, in herpes simplex virus type 1 infection in mice.
    J Med Virol.    impact factor:   2.867
    1995;  46(1): 28-34

    3:  Usui T, Ikeda Y, Tagami T, Matsuda K, Moriyama K, Yamada K, Kuzuya H, Kohno S, Shimatsu A.
    The phytochemical lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors.
    J Endocrinol.    impact factor:   2.58
    2002;  175(2): 289-96

    4:  Ohta H, Ni JW, Matsumoto K, Watanabe H, Shimizu M.
    Peony and its major constituent, paeoniflorin, improve radial maze performance impaired by scopolamine in rats.
    Pharmacol Biochem Behav.    impact factor:   1.732
    1993;  45(3): 719-23

    5:  Yamada H, Kiyohara H, Takemoto N, Zhao JF, Kawamura H, Komatsu Y, Cyong JC, Aburada M, Hosoya E.
    Mitogenic and complement activating activities of the herbal components of juzen-taiho-to.
    Planta Med.    impact factor:   1.438
    1992;  58(2): 166-70

    6:  Kaneko M, Kawakita T, Kumazawa Y, Takimoto H, Nomoto K, Yoshikawa T.
    Accelerated recovery from cyclophosphamide-induced leukopenia in mice administered a Japanese ethical herbal drug, Hochu-ekki-to.
    Immunopharmacology.    impact factor:   1.43
    1999;  44(3): 223-31

    7:  Takei H, Nakauchi K, Yoshizaki F.
    Analysis of swertiamarin in Swertia herb and preparations containing this crude drug by capillary electrophoresis.
    Anal Sci.    impact factor:   1.07
    2001;  17(7): 885-8

    8:  Makino T, Furuta A, Fujii H, Nakagawa T, Wakushima H, Saito K, Kano Y.
    Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice.
    Biol Pharm Bull.    impact factor:   .844
    2001;  24(10): 1206-9

    9:  Okabe S, Suganuma M, Imayoshi Y, Taniguchi S, Yoshida T, Fujiki H.
    New TNF-alpha releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki.
    Biol Pharm Bull.    impact factor:   .844
    2001;  24(10): 1145-8

    10:  Iijima K, Tanaka M, Toriizuka K, Cyong JC.
    Effects of Kampo medicines on the clearance of circulating immune complexes in mice.
    J Ethnopharmacol.    impact factor:   .687
    1994;  41(1-2): 77-83

    11:  Takeshita K, Saisho Y, Kitamura K, Kaburagi N, Funabiki T, Inamura T, Oyamada Y, Asano K, Yamaguchi K.
    Pneumonitis induced by ou-gon (scullcap).
    Intern Med.    impact factor:   .643
    2001;  40(8): 764-8

    12:  Hu SY.
    A contribution to our knowledge of ginseng.
    Am J Chin Med.    impact factor:   .583
    1977;  5(1): 1-23

    13:  Akamatsu H, Asada Y, Horio T.
    Effect of keigai-rengyo-to, a Japanese kampo medicine, on neutrophil functions: a possible mechanism of action of keigai-rengyo-to in acne.
    J Int Med Res.    impact factor:   .535
    1997;  25(5): 255-65

    14:  Sekiya N, Goto H, Shimada Y, Terasawa K.
    Inhibitory effects of Keishi-bukuryo-gan on free radical induced lysis of rat red blood cells.
    Phytother Res.    impact factor:   .364
    2002;  16(4): 373-6

    15:  Nishibe S.
    [The plant origins of herbal medicines and their quality evaluation]
    Yakugaku Zasshi.    impact factor:   .238
    2002;  122(6): 363-79

    16:  Asano S.
    [Structure-function study on gastric proton pump]
    Yakugaku Zasshi.    impact factor:   .238
    1997;  117(7): 379-93

    17:  Nikaido T, Iizuka S, Okada N, Kuge T, Ohmoto T.
    [The study of Chinese herbal medicinal prescription with enzyme inhibitory activity. VI. The study of makyo-kanseki-to with adenosine 3',5'-cyclic monophosphate phosphodiesterase]
    Yakugaku Zasshi.    impact factor:   .238
    1992;  112(2): 124-8

    18:  Nikaido T, Ohmoto T, Kuge T, Yanagisawa A, Teinozawa K, Takeda H, Tsukamoto H.
    [The study on Chinese herbal medicinal prescription with enzyme inhibitory activity. III. The study of mao-to with adenosine 3',5'-cyclic monophosphate phosphodiesterase]
    Yakugaku Zasshi.    impact factor:   .238
    1990;  110(7): 504-8

    19:  Hosoda K, Imoto Y, Jobu J, Noguchi M.
    [Quality evaluation of oriental medicines. I. Quantitative analysis of marker substances in the ethical extract preparation of Hangekouboku-to]
    Yakugaku Zasshi.    impact factor:   .238
    1990;  110(10): 755-8

    20:  Nakazawa K, Fujimori K, Inoue K, Sekita S, Takanaka A.
    [Effects of extract from a herbal drug, cnidium rhizome (senkyu), on contraction, heart rates and membrane potentials of isolated guinea pig atria]
    Yakugaku Zasshi.    impact factor:   .238
    1989;  109(9): 662-71

    21:  Agata I, Nakaya Y, Nishibe S, Hisada S, Kimura K.
    [Studies on the constituents of medicinal plants in Hokkaido. II. On the whole herb of Frasera tetrapetala Pall. (2)]
    Yakugaku Zasshi.    impact factor:   .238
    1984;  104(4): 418-21

    22:  Tashiro Y, Mitani Y, Murata K, Yoshida A, Hayaski S.
    [Analytical studies on the active constituents in crude drugs. IV. Determination and stability of swertiamarin in pharmaceutical preparations including Swert. Herb. Pulv. (author's transl)]
    Yakugaku Zasshi.    impact factor:   .238
    1982;  102(3): 258-63

    23:  Takagi S, Yamaki M, Masuda K, Nishihama Y, Sakina K.
    [Studies on the herb medical materials used for some tumors. II. On the constituents of Hedyotis corymbosa Lam (author's transl)]
    Yakugaku Zasshi.    impact factor:   .238
    1981;  101(7): 657-9

    24:  Agata I, Sekizaki H, Sakushima A, Nishibe S, Hisada S, Kimura K.
    [Studies on the constituents of medicinal plants in Hokkaido. I. On the whole herb of Swertia tetrapetala Pall. (1) (author's transl)]
    Yakugaku Zasshi.    impact factor:   .238
    1981;  101(11): 1067-71

    25:  Noguchi M, Kubo M, Naka Y.
    [Studies on the pharmaceutical quality evaluation of crude drug preparations used in Orient medicine "Kampoo". IV. Behavior of alkaloids in ephedra herb mixed with other crude drugs under decoction processes (author's transl)]
    Yakugaku Zasshi.    impact factor:   .238
    1978;  98(7): 923-8

    26:  Takagi K, Harada M.
    [Pharmacological studies on herb paeony root. I. Central effects of paeoniflorin and combined effects with licorice component Fm 100]
    Yakugaku Zasshi.    impact factor:   .238
    1969;  89(7): 879-86

    27:  Takagi K, Harada M.
    [Pharmacological studies on herb paeony root. II. Anti-inflammatory effect, inhibitory effect on gastric juice secretion, preventive effect on stress ulcer, antidiuretic effect of paeoniflorin and combined effects with licorice component Fm 100]
    Yakugaku Zasshi.    impact factor:   .238
    1969;  89(7): 887-92

    28:  Takagi K, Harada M.
    [Pharmacological studies on herb paeony root. 3. Effects of paeoniflorin on circulatory and respiratory systems and isolated organs]
    Yakugaku Zasshi.    impact factor:   .238
    1969;  89(7): 893-8

    29:  Komatsu M, Tomimori T, Makiguchi Y.
    [Studies on the constituents of the herb of Panax ginseng C. A. Meyer. II. On the flavonoid constituents]
    Yakugaku Zasshi.    impact factor:   .238
    1969;  89(1): 122-6

    30:  Harada M.
    [Pharmacological studies on herb paeony root. IV. Analysis of therapeutic effects of paeony- and licorice-containing frequent prescriptions in Chinese medicine and comparison with effects of experimental pharmacological tests]
    Yakugaku Zasshi.    impact factor:   .238
    1969;  89(7): 899-908

    31:  Uyeo S, Yamato Y.
    [SThe structure of radiatine, a new alkaloid occurring in Lycoris radiata herb]
    Yakugaku Zasshi.    impact factor:   .238
    1965;  85(7): 615-8

    32:  Ozeki S.
    [Studies on the alkaloids of Zephyranthes candida Herb. IV. Stereochemistry of nerinine]
    Yakugaku Zasshi.    impact factor:   .238
    1965;  85(8): 699-702

    33:  Maki J, Mikami M, Maruyama S, Sakagami H, Kuwada M.
    [Discovery of the adult Schistosoma japonicum, a causative agent of Schistosomiasis in the Katayama area of Hiroshima Prefecture]
    Yakushigaku Zasshi.    impact factor:   0
    2001;  36(1): 32-5

    34:  Liu JP, Manheimer E, Tsutani K, Gluud C.
    Medicinal herbs for hepatitis C virus infection.
    Cochrane Database Syst Rev.    impact factor:   0
    2001;  (4): CD003183

    35:  Tsuji M, Saito N, Inoue S.
    [Inhibitors of absorption as anti-obesity drugs]
    Nippon Yakurigaku Zasshi.    impact factor:   0
    2001;  118(5): 340-6

    36:  Kamei T, Kumano H, Iwata K, Nariai Y, Matsumoto T.
    The effect of a traditional Chinese prescription for a case of lung carcinoma.
    J Altern Complement Med.    impact factor:   0
    2000;  6(6): 557-9

    37:  Yamashiki M, Nishimura A, Huang XX, Nobori T, Sakaguchi S, Suzuki H.
    Effects of the Japanese herbal medicine "Sho-saiko-to" (TJ-9) on interleukin-12 production in patients with HCV-positive liver cirrhosis.
    Dev Immunol.    impact factor:   0
    1999;  7(1): 17-22

    38:  Kim JS, Lee WK, Suh JS, Song KE, Lee JW, Kim PT, Lee YS, Lee JN, Kang BJ, Kim DH, et al.
    [Unification of Oriental and Western medicine with study on Oriental and Western medicine]
    Uisahak.    impact factor:   0
    1998;  7(1): 47-61

    39:  Ofuji K, Hara H, Sukamoto T, Yamashita S.
    [Effects of an antidiarrhoeica containing an extract from geranium herb on astringent action and short-circuit current across jejunal mucosa]
    Nippon Yakurigaku Zasshi.    impact factor:   0
    1998;  111(4): 265-75

    40:  Takakuwa E.
    [Present state of countermeasure to AIDS in the world today]
    Kansenshogaku Zasshi.    impact factor:   0
    1997;  71(11): 1097-107

    41:  Kadota S, Basnet P, Ishii E, Tamura T, Namba T.
    Antibacterial activity of trichorabdal A from Rabdosia trichocarpa against Helicobacter pylori.
    Zentralbl Bakteriol.    impact factor:   0
    1997;  286(1): 63-7

    42:  Endo S.
    [The origin and development of the herbal gardens of the Owari clan]
    Nippon Ishigaku Zasshi.    impact factor:   0
    1996;  42(4): 503-20

    43:  Shibata T, Morimoto T, Suzuki A, Saito H, Yanaihara T.
    [The effect of Shakuyaku-kanzo-to on prostaglandin production in human uterine myometrium]
    Nippon Sanka Fujinka Gakkai Zasshi.    impact factor:   0
    1996;  48(5): 321-7

    44:  Higuchi Y, Yamashita K, Taniyama K, Satake M, Ozaki M.
    [Shichimotsu-koka-to prevents stroke and changes free-radical-related enzymes in stroke-prone spontaneously hypertensive rats (SHRSP)]
    Nippon Yakurigaku Zasshi.    impact factor:   0
    1996;  108(1): 13-22

    45:  Goto T, Yamaguchi S, Tanaka T.
    [Study of "Bishu Yakuen Ransho-Roku (the origin of herb garden in Owari Clan)]
    Yakushigaku Zasshi.    impact factor:   0
    1995;  30(1): 18-24

    46:  Nishioji K, Itoh Y, Sakamoto Y, Tokita K, Mitsufuji S, Yokota S, Tsuji T, Okanoue T, Kashima K.
    [A case of drug-induced hepatitis caused by Oriental herb-drug sai-rei-to]
    Nippon Shokakibyo Gakkai Zasshi.    impact factor:   0
    1994;  91(10): 2016-20

    47:  Sakata Y, Suzuki H, Kamataki T.
    [Preventive effect of TJ-14, a kampo (Chinese herb) medicine, on diarrhea induced by irinotecan hydrochloride (CPT-11)]
    Gan To Kagaku Ryoho.    impact factor:   0
    1994;  21(8): 1241-4

    48:  Amano H, Kawabuchi M, Tanaka Y, Sugihara M.
    [Japanese medicines studied by Hepburn, an American missionary, in 1860s]
    Yakushigaku Zasshi.    impact factor:   0
    1994;  29(1): 73-8

    49:  Goto T, Tanaka T, Yamaguchi S.
    [On a circular notice about herbs in Kisodani of mid-Edo period]
    Yakushigaku Zasshi.    impact factor:   0
    1994;  29(1): 1-8

    50:  Yanagisawa K, Yamada M, Matsumoto Y.
    [The transition of psychotropic drugs in Japanese Pharmacopoeia (JP) (Part 7). The study for cultivation of Valeriannae Radix in Hokkaido area]
    Yakushigaku Zasshi.    impact factor:   0
    1994;  29(1): 64-72

    51:  Furuya I, Watanabe S.
    [Discriminative stimulus properties of ephedra herb (Ephedra sinica) in rats]
    Yakubutsu Seishin Kodo.    impact factor:   0
    1993;  13(1): 33-8

    52:  Tadano T, Aizawa T, Asao T, Hozumi M, Kisara K.
    [Pharmacological studies of nutritive and tonic crude drugs on fatigue in mice]
    Nippon Yakurigaku Zasshi.    impact factor:   0
    1992;  100(5): 423-31

    53:  Matsuta K, Kikuna T.
    [Physical therapy and Oriental medicine applied to rheumatoid arthritis]
    Nippon Rinsho.    impact factor:   0
    1992;  50(3): 563-69

    54:  Yoshimoto S.
    [Chinese medicine discovered in "Jing Ping Mei"]
    Nippon Ishigaku Zasshi.    impact factor:   0
    1992;  38(1): 133-63

    55:  Shimizu T, Inoue T, Mizuno M, Kuang Y.
    [Historical and herbalogical studies on coloring crude drug (Part 1): "Langbacao"]
    Yakushigaku Zasshi.    impact factor:   0
    1992;  27(2): 55-64

    56:  Nagata M, Kawaguchi H, Komatsu Y, Hattori M, Itoh K.
    [The effects of sairei-to on nephrotoxic serum nephritis in rats--possible effects on intraglomerular cell mediated immunity]
    Nippon Jinzo Gakkai Shi.    impact factor:   0
    1989;  31(7): 713-21

    57:  Ebisuno S, Hirano A, Kyoku I, Ohkawa T, Iijima O, Fujii Y, Hosoya E.
    [Basal studies on combination of Chinese medicine in cancer chemotherapy: protective effects on the toxic side effects of CDDP and antitumor effects with CDDP on murine bladder tumor (MBT-2)]
    Nippon Gan Chiryo Gakkai Shi.    impact factor:   0
    1989;  24(6): 1305-12

    58:  Nagai N, Katayama Y, Iguchi M, Esa A, Tsuzihashi H.
    [Treatment in male infertile clinic of Kaizuka Municipal Hospital]
    Hinyokika Kiyo.    impact factor:   0
    1988;  34(5): 839-46

    59:  Komiyama K, Hirokawa Y, Zhibo Y, Umezawa I, Hata T.
    [Potentiation of chemotherapeutic activity by a Chinese herb medicine juzen-taiho-toh]
    Gan To Kagaku Ryoho.    impact factor:   0
    1988;  15(5): 1715-9

    60:  Hamada T.
    [On the herb garden, located at Chawan-yama, of the fief of Hosokawa, Higo district] (Jpn).]
    Yakushigaku Zasshi.    impact factor:   0
    1987;  22(2): 66-71

    61:  Yoshida H, Tanifuji T, Sakurai H, Tashiro H, Ogawa H, Imamura K.
    [Clinical effects of Chinese herb medicine (hochu-ekki-to) on infertile men]
    Hinyokika Kiyo.    impact factor:   0
    1986;  32(2): 297-302

    62:  Hamada T.
    [On the herb garden of the fief of Sagara at Hitoyoshi] (Jpn).]
    Yakushigaku Zasshi.    impact factor:   0
    1986;  21(2): 77-80

    63:  Kawakita T, Yamada A, Kumazawa Y, Nomoto K.
    Accumulation of immature B and null lymphocytes in the periphery after intraperitoneal administration of traditional Chinese medicine, xiao-chai-hu-tang (Japanese name: shosaiko-to).
    J Immunopharmacol.    impact factor:   0
    1986;  8(4): 561-88

    64:  Shibusawa K.
    [Medical topics. Hepatic vein obstruction caused by herb tea. Relationship between Hbe antigen and s antigen carriers]
    Kango.    impact factor:   0
    1984;  36(4): 92-3

    65:  Ohta T, Tawara M, Tatsuka M, Abe H, Odashima S.
    [An approach to prolongation of survival rate in tumor bearing mice using 5-fluorouracil in combination with various kinds of herb medicine]
    Gan To Kagaku Ryoho.    impact factor:   0
    1983;  10(8): 1858-65

    66:  Ito H, Unno M, Kubota Y.
    [Oriental diagnostic methods and herb medicine]
    Kokubyo Gakkai Zasshi.    impact factor:   0
    1977;  44(3): 274


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