| ID |
Name |
Structure |
Top 10 Available References (order by impact factor) |
Molecular Target(s) |
| 1 | Compound ID:63
OLEANDRIGENIN
Activity Tested(uM): 0.01NSC#:148790 Cell Data(<1uM)
|
C25H36O6 432.55
| 1: Wang X, Plomley JB, Newman RA, Cisneros A.
LC/MS/MS analyses of an oleander extract for cancer treatment.
Anal Chem. impact factor: 4.555
2000; 72(15): 3547-52
2: Jortani SA, Helm RA, Valdes R Jr.
Inhibition of Na,K-ATPase by oleandrin and oleandrigenin, and their detection by digoxin immunoassays.
Clin Chem. impact factor: 3.769
1996; 42(10): 1654-8
3: Smith JA, Madden T, Vijjeswarapu M, Newman RA.
Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin.
Biochem Pharmacol. impact factor: 2.755
2001; 62(4): 469-72
4: Hauser E, Boffo U, Meister L, Sawlewicz L, Linde HH, Meyer K.
[3-amino-3-desoxy compounds from uzarigenin, oleandrigenin, gitoxigenin, and digoxigenin. Partial synthesis experiments in the series of cardiac poisons. 6]
Helv Chim Acta. impact factor: 2.483
1973; 56(8): 2782-95
5: Arao T, Fuke C, Takaesu H, Nakamoto M, Morinaga Y, Miyazaki T.
Simultaneous determination of cardenolides by sonic spray ionization liquid chromatography-ion trap mass spectrometry--a fatal case of oleander poisoning.
J Anal Toxicol. impact factor: 2.221
2002; 26(4): 222-7
| |
| 2 | Compound ID:102
ACRONYCINE
Activity Tested(uM): 0.89NSC#:403169 Cell Data(<1uM)
|
C20H19NO3 321.37
| 1: Dorr RT, Liddil JD, Von Hoff DD, Soble M, Osborne CK.
Antitumor activity and murine pharmacokinetics of parenteral acronycine.
Cancer Res. impact factor: 8.614
1989; 49(2): 340-4
2: Tong AW, Lee J, Wang RM, Dalton WS, Tsuruo T, Fay JW, Stone MJ.
Elimination of chemoresistant multiple myeloma clonogenic colony-forming cells by combined treatment with a plasma cell-reactive monoclonal antibody and a P-glycoprotein-reactive monoclonal antibody.
Cancer Res. impact factor: 8.614
1989; 49(17): 4829-34
3: Dalton WS, Durie BG, Alberts DS, Gerlach JH, Cress AE.
Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein.
Cancer Res. impact factor: 8.614
1986; 46(10): 5125-30
4: Tan P, Auersperg N.
Effects of the antineoplastic alkaloid acronycine on the ultrastructure and growth patterns of cultured cells.
Cancer Res. impact factor: 8.614
1973; 33(10): 2320-9
5: Dunn BP, Gout PW, Beer CT.
Effects of the antineoplastic alkaloid acronycine on nucleoside uptake and incorporation into nucleic acids by cultured L5178Y cells.
Cancer Res. impact factor: 8.614
1973; 33(10): 2310-9
| |
| 3 | Compound ID:165
AILANTHINONE
Activity Tested(uM): 0.01NSC#:238187 Cell Data(<1uM)
NSC#:277285
NSC#:312626
|
C25H34O9 478.53
| 1: Ekong RM, Kirby GC, Patel G, Phillipson JD, Warhurst DC.
Comparison of the in vitro activities of quassinoids with activity against Plasmodium falciparum, anisomycin and some other inhibitors of eukaryotic protein synthesis.
Biochem Pharmacol. impact factor: 2.755
1990; 40(2): 297-301
2: Kirby GC, O'Neill MJ, Phillipson JD, Warhurst DC.
In vitro studies on the mode of action of quassinoids with activity against chloroquine-resistant Plasmodium falciparum.
Biochem Pharmacol. impact factor: 2.755
1989; 38(24): 4367-74
3: Wright CW, Anderson MM, Allen D, Phillipson JD, Kirby GC, Warhurst DC, Chang HR.
Quassinoids exhibit greater selectivity against Plasmodium falciparum than against Entamoeba histolytica, Giardia intestinalis or Toxoplasma gondii in vitro.
J Eukaryot Microbiol. impact factor: 1.417
1993; 40(3): 244-6
4: O'Neill MJ, Bray DH, Boardman P, Wright CW, Phillipson JD, Warhurst DC, Gupta MP, Correya M, Solis P.
Plants as sources of antimalarial drugs, Part 6: Activities of Simarouba amara fruits.
J Ethnopharmacol. impact factor: .687
1988; 22(2): 183-90
5: Ghosh PC, Larrahondo JE, LeQuesne PW, Raffauf RF.
Antitumor plants. IV. Constituents of Simarouba versicolor.
Lloydia. impact factor: 0
1977; 40(4): 364-9
| |
| 4 | Compound ID:181
HELENINE
Activity Tested(uM): 1.19NSC#:93131 Cell Data(>1uM)
Activity Tested(uM): 0.47 NSC#:302289 Cell Data(<1uM)
|
C15H20O2 232.32
| 1: Shope RE.
An antiviral substance from Penicillium funiculosum. VI. Prevention of the establishment of passive immunity to Semliki Forest virus infection in mice by Helenine.
J Exp Med. impact factor: 15.651
1966; 124(1): 15-31
2: Cheng PY, Shope RE.
The presence in Penicillium funiculosum of an inhibitor to the antiviral agent helenine.
J Exp Med. impact factor: 15.651
1966; 123(3): 505-8
3: Rytel MW, Shope RE, Kilbourne ED.
An antiviral substance from Penicillium funiculosum. V. Induction of interferon by helenine.
J Exp Med. impact factor: 15.651
1966; 123(4): 577-84
4: Shope RE.
An antiviral substance from Penicillium funiculosum. VII. An attempt to determine whether the material responsible for the antipassive immunity effect exhibited by mice injected with helenine is an interferon.
J Exp Med. impact factor: 15.651
1966; 124(5): 915-9
5: Shope RE.
An antiviral substance from Penicillium funiculosum. IV. Inquiry into the mechanism by which helenine exerts its antiviral effect.
J Exp Med. impact factor: 15.651
1966; 123(2): 213-27
| |
| 5 | Compound ID:219
ALLOSECURININE
Activity Tested(uM): 0.47NSC#:107413 Cell Data(<1uM)
Activity Tested(uM): 4.14 NSC#:107414 Cell Data(>1uM)
Activity Tested(uM): 19.23 NSC#:107415 Cell Data(>1uM)
NSC#:326131
Aldrich#:S3138 |
C13H15NO2 217.27
| 1: Rognan D, Boulanger T, Hoffmann R, Vercauteren DP, Andre JM, Durant F, Wermuth CG.
Structure and molecular modeling of GABAA receptor antagonists.
J Med Chem. impact factor: 4.079
1992; 35(11): 1969-77
2: Beutler JA, Karbon EW, Brubaker AN, Malik R, Curtis DR, Enna SJ.
Securinine alkaloids: a new class of GABA receptor antagonist.
Brain Res. impact factor: 2.302
1985; 330(1): 135-40
3: Horii Z, Yamawaki Y, Tamura Y, Saito S, Yoshikawa H, Kotera K.
Degradations of allosecurinine.
Chem Pharm Bull (Tokyo). impact factor: 1.117
1965; 13(11): 1311-8
| |
| 6 | Compound ID:220
ALLOYOHIMBINE
Activity Tested(uM): 1.05NSC#:19509 Cell Data(>1uM)
NSC#:72116
NSC#:93133
Activity Tested(uM): 59.43 NSC#:407306 Cell Data(>1uM)
Activity Tested(uM): 0.01 NSC#:407307 Cell Data(<1uM)
Aldrich#:230480
Aldrich#:C3255 |
C21H26N2O3 354.45
| 1: Ferry N, Goodhardt M, Hanoune J, Sevenet T.
Binding of yohimbine stereoisomers to alpha-adrenoceptors in rat liver and human platelets.
Br J Pharmacol. impact factor: 3.722
1983; 78(2): 359-64
| |
| 7 | Compound ID:377
ANNONACIN
Activity Tested(uM): 0.01NSC#:606194 Cell Data(<1uM)
Activity Tested(uM): 0.06 NSC#:695404 Cell Data(<1uM)
|
C35H64O7 596.88
| 1: Hu TS, Yu Q, Wu YL, Wu Y.
Enantioselective syntheses of monotetrahydrofuran Annonaceous acetogenins tonkinecin and annonacin starting from carbohydrates.
J Org Chem. impact factor: 3.44
2001; 66(3): 853-61
2: Hu TS, Wu YL, Wu Y.
The first total synthesis of annonacin, the most typical monotetrahydrofuran annonaceous acetogenins.
Org Lett. impact factor: 3.367
2000; 2(7): 887-9
3: Wang LQ, Min BS, Li Y, Nakamura N, Qin GW, Li CJ, Hattori M.
Annonaceous acetogenins from the leaves of Annona montana.
Bioorg Med Chem. impact factor: 1.799
2002; 10(3): 561-5
4: Liaw CC, Chang FR, Lin CY, Chou CJ, Chiu HF, Wu MJ, Wu YC.
New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata.
J Nat Prod. impact factor: 1.652
2002; 65(4): 470-5
5: Mootoo BS, Ali A, Khan A, Reynolds WF, McLean S.
Three novel monotetrahydrofuran annonaceous acetogenins from Annona montana.
J Nat Prod. impact factor: 1.652
2000; 63(6): 807-11
| |
| 8 | Compound ID:393
ANTHRICIN
NSC#:332044
NSC#:332045
Activity Tested(uM): 0NSC#:403148 Cell Data(<1uM)
|
C22H22O7 398.41
| 1: Ikeda R, Nagao T, Okabe H, Nakano Y, Matsunaga H, Katano M, Mori M.
Antiproliferative constituents in umbelliferae plants. III. Constituents in the root and the ground part of Anthriscus sylvestris Hoffm.
Chem Pharm Bull (Tokyo). impact factor: 1.117
1998; 46(5): 871-4
2: Yamamoto D, Ohishi H, Kozawa M, Inamori Y, Ishida T, Inoue M.
Study on conformations--biological activities relationships for podophyllotoxin analogues based on crystal structure of deoxypodophyllotoxin (anthricin).
Chem Pharm Bull (Tokyo). impact factor: 1.117
1988; 36(9): 3239-47
3: Inamori Y, Kato Y, Kubo M, Baba K, Ishida T, Nomoto K, Kozawa M.
The biological actions of deoxypodophyllotoxin (anthricin). I. Physiological activities and conformational analysis of deoxypodophyllotoxin.
Chem Pharm Bull (Tokyo). impact factor: 1.117
1985; 33(2): 704-9
| |
| 9 | Compound ID:399
APIGENIN-7-GLUCOSIDE
Activity Tested(uM): 0.08NSC#:407303 Cell Data(<1uM)
|
C21H20O10 432.38
| 1: Day AJ, DuPont MS, Ridley S, Rhodes M, Rhodes MJ, Morgan MR, Williamson G.
Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity.
FEBS Lett. impact factor: 3.72
1998; 436(1): 71-5
2: Silfen J, Yanai P, Cabantchik ZI.
Bioflavonoid effects on in vitro cultures of Plasmodium falciparum. Inhibition of permeation pathways induced in the host cell membrane by the intraerythrocytic parasite.
Biochem Pharmacol. impact factor: 2.755
1988; 37(22): 4269-76
3: Lambert N, Kroon PA, Faulds CB, Plumb GW, McLauchlan WR, Day AJ, Williamson G.
Purification of cytosolic beta-glucosidase from pig liver and its reactivity towards flavonoid glycosides.
Biochim Biophys Acta. impact factor: 2.59
1999; 1435(1-2): 110-6
4: Liu Y, Hu M.
Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model.
Drug Metab Dispos. impact factor: 2.519
2002; 30(4): 370-7
5: Julkunen-Tiitto R, Sorsa S.
Testing the effects of drying methods on willow flavonoids, tannins, and salicylates.
J Chem Ecol. impact factor: 1.653
2001; 27(4): 779-89
| |
| 10 | Compound ID:401
APIGENIN-7-GLUCURONIDE
Activity Tested(uM): 0.01NSC#:622811 Cell Data(<1uM)
|
C21H18O11 446.36
| 1: Williams CA, Hoult JR, Harborne JB, Greenham J, Eagles J.
A biologically active lipophilic flavonol from Tanacetum parthenium.
Phytochemistry. impact factor: 1.106
1995; 38(1): 267-70
2: Lu J, Feng X, Sun Q, Lu H, Manabe M, Sugahara K, Ma D, Sagara Y, Kodama H.
Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils.
Clin Chim Acta. impact factor: 1.035
2002; 316(1-2): 95-9
3: Williams CA, Greenham J, Harborne JB.
The role of lipophilic and polar flavonoids in the classification of temperate members of the Anthemideae.
Biochem Syst Ecol. impact factor: .758
2001; 29(9): 929-945
| |