| ID |
Name |
Structure |
Top 10 Available References (order by impact factor) |
Molecular Target(s) |
| 1 | Compound ID:2 ABIETIC ACID NSC#:13163 Activity Tested(uM): 35.73NSC#:25149 Cell Data(>1uM) NSC#:58970 NSC#:154789 NSC#:224312 NSC#:224316 NSC#:226139
Aldrich#:00010 Aldrich#:165026 Aldrich#:A9424 |
C20H30O2 302.45
| 1: Vogel BS, Wildung MR, Vogel G, Croteau R. Abietadiene synthase from grand fir (Abies grandis). cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase involved in resin acid biosynthesis. J Biol Chem. impact factor: 7.666 1996; 271(38): 23262-8
2: Imaizumi Y, Sakamoto K, Yamada A, Hotta A, Ohya S, Muraki K, Uchiyama M, Ohwada T. Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit. Mol Pharmacol. impact factor: 5.465 2002; 62(4): 836-46
3: Peters RJ, Flory JE, Jetter R, Ravn MM, Lee HJ, Coates RM, Croteau RB. Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme. Biochemistry. impact factor: 4.493 2000; 39(50): 15592-602
4: Funk C, Lewinsohn E, Vogel BS, Steele CL, Croteau R. Regulation of Oleoresinosis in Grand Fir (Abies grandis) (Coordinate Induction of Monoterpene and Diterpene Cyclases and Two Cytochrome P450-Dependent Diterpenoid Hydroxylases by Stem Wounding). Plant Physiol. impact factor: 4.434 1994; 106(3): 999-1005
5: Cross BE, Myers PL. The bacterial transformation of abietic acid. Biochem J. impact factor: 4.349 1968; 108(2): 303-10
| |
| 2 | Compound ID:3 ABRINE
Aldrich#:434248 |
C12H14N2O2 218.25
| 1: Richou R, Lallouette P, Richou H. [Contribution to the study of the modifications of inflammatory reactions, induced by abrine, in guinea pigs immunized with ana-abrine] C R Acad Sci Hebd Seances Acad Sci D. impact factor: 0 1966; 263(3): 308-9
| |
| 3 | Compound ID:4 ABSCISIC ACID NSC#:146877 Activity Tested(uM): 100NSC#:148832 Cell Data(>1uM)
Aldrich#:00012 Aldrich#:862169 Aldrich#:A0560 Aldrich#:A1012 Aldrich#:A1049 Aldrich#:A4906 Aldrich#:A7383 Aldrich#:A8451 Aldrich#:R277282 |
C15H20O4 264.32
| 1: Abe H, Urao T, Ito T, Seki M, Shinozaki K, Yamaguchi-Shinozaki K. Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) Function as Transcriptional Activators in Abscisic Acid Signaling. Plant Cell. impact factor: 10.463 2003; 15(1): 63-78
2: Casaretto J, Ho TH. The Transcription Factors HvABI5 and HvVP1 Are Required for the Abscisic Acid Induction of Gene Expression in Barley Aleurone Cells. Plant Cell. impact factor: 10.463 2003; 15(1): 271-84
3: Zhu J, Gong Z, Zhang C, Song CP, Damsz B, Inan G, Koiwa H, Zhu JK, Hasegawa PM, Bressan RA. OSM1/SYP61: a syntaxin protein in Arabidopsis controls abscisic acid-mediated and non-abscisic acid-mediated responses to abiotic stress. Plant Cell. impact factor: 10.463 2002; 14(12): 3009-28
4: Jung JY, Kim YW, Kwak JM, Hwang JU, Young J, Schroeder JI, Hwang I, Lee Y. Phosphatidylinositol 3- and 4-phosphate are required for normal stomatal movements. Plant Cell. impact factor: 10.463 2002; 14(10): 2399-412
5: Zheng ZL, Nafisi M, Tam A, Li H, Crowell DN, Chary SN, Schroeder JI, Shen J, Yang Z. Plasma membrane-associated ROP10 small GTPase is a specific negative regulator of abscisic acid responses in Arabidopsis. Plant Cell. impact factor: 10.463 2002; 14(11): 2787-97
| |
| 4 | Compound ID:6 ACACETIN NSC#:76061
Aldrich#:00017 |
C16H12O5 284.27
| 1: Boege F, Straub T, Kehr A, Boesenberg C, Christiansen K, Andersen A, Jakob F, Kohrle J. Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I. J Biol Chem. impact factor: 7.666 1996; 271(4): 2262-70
2: Fiorani M, De Sanctis R, De Bellis R, Dacha M. Intracellular flavonoids as electron donors for extracellular ferricyanide reduction in human erythrocytes. Free Radic Biol Med. impact factor: 4.116 2002; 32(1): 64-72
3: Chen YT, Zheng RL, Jia ZJ, Ju Y. Flavonoids as superoxide scavengers and antioxidants. Free Radic Biol Med. impact factor: 4.116 1990; 9(1): 19-21
4: Wenzel U, Kuntz S, Daniel H. Flavonoids with epidermal growth factor-receptor tyrosine kinase inhibitory activity stimulate PEPT1-mediated cefixime uptake into human intestinal epithelial cells. J Pharmacol Exp Ther. impact factor: 3.3 2001; 299(1): 351-7
5: Bylka W, Franski R, Stobiecki M. Differentiation between isomeric acacetin-6-C-(6"-O-malonyl)glucoside and acacetin-8-C-(6"-O-malonyl)glucoside by using low-energy CID mass spectra. J Mass Spectrom. impact factor: 3.167 2002; 37(6): 648-50
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| 5 | Compound ID:20 ACETAL NSC#:227930
Aldrich#:176958 Aldrich#:81890 |
C7H16O2 132.2
| 1: Guindon Y, Ogilvie WW, Bordeleau J, Cui WL, Durkin K, Gorys V, Juteau H, Lemieux R, Liotta D, Simoneau B, Yoakim C. Opening of Tartrate Acetals Using Dialkylboron Bromide: Evidence for Stereoselectivity Downstream from Ring Fission. J Am Chem Soc. impact factor: 5.537 2003; 125(2): 428-436
2: Murahashi S, Imada Y, Kawakami T, Harada K, Yonemushi Y, Tomita N. Enantioselective addition of ketene silyl acetals to nitrones catalyzed by chiral titanium complexes. Synthesis of optically active beta-amino acids. J Am Chem Soc. impact factor: 5.537 2002; 124(12): 2888-9
3: Fletcher MT, Wood BJ, Brereton IM, Stok JE, De Voss JJ, Kitching W. (18)O]-oxygen incorporation reveals novel pathways in spiroacetal biosynthesis by Bactrocera cacuminata and B. cucumis. J Am Chem Soc. impact factor: 5.537 2002; 124(26): 7666-7
4: Nishikawa T, Asai M, Isobe M. Asymmetric total synthesis of 11-deoxytetrodotoxin, a naturally occurring congener. J Am Chem Soc. impact factor: 5.537 2002; 124(26): 7847-52
5: Kim S, Lim CJ, Song C, Chung WJ. Novel radical alkylation of carboxylic imides. J Am Chem Soc. impact factor: 5.537 2002; 124(48): 14306-7
| |
| 6 | Compound ID:21 ACETAMIDE NSC#:25945 NSC#:244792
Aldrich#:00160 Aldrich#:122637 Aldrich#:150703 Aldrich#:487775 Aldrich#:A0500 |
C2H5NO 59.07
| 1: Kleymann G, Fischer R, Betz UA, Hendrix M, Bender W, Schneider U, Handke G, Eckenberg P, Hewlett G, Pevzner V, Baumeister J, Weber O, Henninger K, Keldenich J, Jensen A, Kolb J, Bach U, Popp A, Maben J, Frappa I, Haebich D, Lockhoff O, Rubsamen-Waigmann H. New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. Nat Med. impact factor: 26.584 2002; 8(4): 392-8
2: Chavez JC, LaManna JC. Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1. J Neurosci. impact factor: 8.955 2002; 22(20): 8922-31
3: Schroder D, Loos J, Thissen R, Dutuit O, Mourgues P, Audier HE, Lifshitz C, Schwarz H. Barrier height titration by tunable photoionization combined with chemical monitoring: unimolecular keto/enol tautomerization of the acetamide cation radical. Angew Chem Int Ed Engl. impact factor: 7.996 2002; 41(15): 2748-51
4: Rappert A, Biber K, Nolte C, Lipp M, Schubel A, Lu B, Gerard NP, Gerard C, Boddeke HW, Kettenmann H. Secondary lymphoid tissue chemokine (CCL21) activates CXCR3 to trigger a Cl- current and chemotaxis in murine microglia. J Immunol. impact factor: 7.145 2002; 168(7): 3221-6
5: Richard JP, Williams G, O'Donoghue AC, Amyes TL. Formation and stability of enolates of acetamide and acetate anion: an Eigen plot for proton transfer at alpha-carbonyl carbon. J Am Chem Soc. impact factor: 5.537 2002; 124(12): 2957-68
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| 7 | Compound ID:23 ACETOIN NSC#:7609 NSC#:89727
Aldrich#:00540 Aldrich#:A17951 |
C4H8O2 88.11
| 1: Aevarsson A, Seger K, Turley S, Sokatch JR, Hol WG. Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes. Nat Struct Biol. impact factor: 13.555 1999; 6(8): 785-92
2: Nakagawa J, Ishikura S, Asami J, Isaji T, Usami N, Hara A, Sakurai T, Tsuritani K, Oda K, Takahashi M, Yoshimoto M, Otsuka N, Kitamura K. Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney. J Biol Chem. impact factor: 7.666 2002; 277(20): 17883-91
3: Gonzalez E, Fernandez MR, Larroy C, Sola L, Pericas MA, Pares X, Biosca JA. Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene. J Biol Chem. impact factor: 7.666 2000; 275(46): 35876-85
4: Maestri O, Joset F. Regulation by external pH and stationary growth phase of the acetolactate synthase from Synechocystis PCC6803. Mol Microbiol. impact factor: 6.361 2000; 37(4): 828-38
5: Sergienko EA, Jordan F. New model for activation of yeast pyruvate decarboxylase by substrate consistent with the alternating sites mechanism: demonstration of the existence of two active forms of the enzyme. Biochemistry. impact factor: 4.493 2002; 41(12): 3952-67
| |
| 8 | Compound ID:24 APOCYNIN NSC#:2146 NSC#:209524
Aldrich#:55539 Aldrich#:A10809 |
C9H10O3 166.18
| 1: Beukelman CJ, Van den Berg AJ, Kroes BH, Labadie RP, Mattsson EE, Van Dijk H. Plant-derived metabolites with synergistic antioxidant activity. Immunol Today. impact factor: 17.134 1995; 16(2): 108
2: Satriano J, Schlondorff D. Activation and attenuation of transcription factor NF-kB in mouse glomerular mesangial cells in response to tumor necrosis factor-alpha, immunoglobulin G, and adenosine 3':5'-cyclic monophosphate. Evidence for involvement of reactive oxygen species. J Clin Invest. impact factor: 10.921 1994; 94(4): 1629-36
3: Venugopal SK, Devaraj S, Yang T, Jialal I. Alpha-tocopherol decreases superoxide anion release in human monocytes under hyperglycemic conditions via inhibition of protein kinase C-alpha. Diabetes. impact factor: 9.019 2002; 51(10): 3049-54
4: Oeckler RA, Kaminski PM, Wolin MS. Stretch Enhances Contraction of Bovine Coronary Arteries via an NAD(P)H Oxidase-Mediated Activation of the Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Cascade. Circ Res. impact factor: 8.281 2003; 92(1): 23-31
5: Touyz RM, Chen X, Tabet F, Yao G, He G, Quinn MT, Pagano PJ, Schiffrin EL. Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II. Circ Res. impact factor: 8.281 2002; 90(11): 1205-13
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| 9 | Compound ID:26 D-8-ACETOXYCARVOTANACETO-NE
Aldrich#:R279137 |
C12H18O3 210.27
| no reference available. | |
| 10 | Compound ID:44 ACETYLBORNEOL NSC#:59853 NSC#:62486 NSC#:163480 NSC#:407158
Aldrich#:45853 Aldrich#:45855 Aldrich#:B55203 Aldrich#:S351547 |
C12H20O2 196.29
| no reference available. | |