Found 75 FDA approved compounds.
ID Name Structure Top 10 Available References (order by impact factor) Molecular Target(s)
1Compound ID:112
ADENOSINE
NSC#:7359
NSC#:7652
Activity Tested(uM): 22.86

NSC#:70422 Cell Data(>1uM)
NSC#:80832
NSC#:87676
NSC#:91041
NSC#:247519
Activity Tested(uM): 22.28

NSC#:404241 Cell Data(>1uM)
NSC#:627048

Aldrich#:01832
Aldrich#:01890
Aldrich#:146595
Aldrich#:284971
Aldrich#:A016
Aldrich#:A4036
Aldrich#:A4676
Aldrich#:A5762
Aldrich#:A8157
Aldrich#:A9251
Aldrich#:R465550
FDA approved!!!

C10H13N5O4    267.24



1:  Starai VJ, Celic I, Cole RN, Boeke JD, Escalante-Semerena JC.
Sir2-Dependent Activation of Acetyl-CoA Synthetase by Deacetylation of Active Lysine.
Science.    impact factor:   24.595
2002;  298(5602): 2390-2

2:  Campas C, Lopez JM, Santidrian AF, Barragan M, Bellosillo B, Colomer D, Gil J.
Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes.
Blood.    impact factor:   8.782
2003;   [e-pub ahead of print]

3:  Schmidt VA, Scudder L, Devoe CE, Bernards A, Cupit LD, Bahou WF.
IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization.
Blood.    impact factor:   8.782
2002;   [e-pub ahead of print]

4:  Ghosh D, Ezashi T, Ostrowski MC, Roberts RM.
A Central Role for Ets-2 in the Transcriptional Regulation and Cyclic Adenosine 5'-Monophosphate Responsiveness of the Human Chorionic Gonadotropin-beta Subunit Gene.
Mol Endocrinol.    impact factor:   7.566
2003;  17(1): 11-26

5:  Marzilli M, Sambuceti G, Testa R, Fedele S.
Platelet glycoprotein IIb/IIIa receptor blockade and coronary resistance in unstable angina.
J Am Coll Cardiol.    impact factor:   7.368
2002;  40(12): 2102-9

 
2Compound ID:127
ADRENALINE(L)
NSC#:62786

Aldrich#:02250
Aldrich#:02252
Aldrich#:219304
Aldrich#:316741
Aldrich#:E1635
Aldrich#:E4250
FDA approved!!!
C9H13NO3    183.21



1:  Warrell DA.
Bites of venomous snakes.
N Engl J Med.    impact factor:   28.857
2002;  347(22): 1804-5; author reply 1804-5

2:  Schofield I, Malik R, Izzard A, Austin C, Heagerty A.
Vascular structural and functional changes in type 2 diabetes mellitus: evidence for the roles of abnormal myogenic responsiveness and dyslipidemia.
Circulation.    impact factor:   9.903
2002;  106(24): 3037-43

3:  Ohuchi H, Ohashi H, Park J, Hayashi J, Miyazaki A, Echigo S.
Abnormal postexercise cardiovascular recovery and its determinants in patients after right ventricular outflow tract reconstruction.
Circulation.    impact factor:   9.903
2002;  106(22): 2819-26

4:  Brunner EJ, Hemingway H, Walker BR, Page M, Clarke P, Juneja M, Shipley MJ, Kumari M, Andrew R, Seckl JR, Papadopoulos A, Checkley S, Rumley A, Lowe GD, Stansfeld SA, Marmot MG.
Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study.
Circulation.    impact factor:   9.903
2002;  106(21): 2659-65

5:  Lechin F, Lechin M, van der Dijs B.
Plasma catecholamines and chronic congestive heart failure.
Circulation.    impact factor:   9.903
2002;  106(25): e222; author reply e222

 
3Compound ID:210
ALLOCHENODEOXYCHOLIC ACID
Activity Tested(uM): 12.05

NSC#:657949 Cell Data(>1uM)
Activity Tested(uM): 25.12

NSC#:657950 Cell Data(>1uM)
NSC#:683769

Aldrich#:224545
Aldrich#:22510
Aldrich#:859109
Aldrich#:94465
Aldrich#:C9377
Aldrich#:U5127
FDA approved!!!

C24H40O4    392.58



1:  Shefer S, Hauser S, Salen G, Zaki FG, Bullock J, Salgado E, Shevitz J.
Comparative effects of cholestanol and cholesterol on hepatic sterol and bile acid metabolism in the rat.
J Clin Invest.    impact factor:   10.921
1984;  74(5): 1773-81

2:  Mui MM, Elliott WH.
Bile acids. XXXII. Allocholic acid, a metabolite of allochenodeoxycholic acid in bile fistula rats.
J Biol Chem.    impact factor:   7.666
1971;  246(2): 302-4

3:  Ziller SA Jr, Doisy EA Jr, Elliott WH.
Bile acids. XXV. Allochenodeoxycholic acid, a metabolite of 5 alpha-cholestan-3 beta-ol in the hyperthyroid rat.
J Biol Chem.    impact factor:   7.666
1968;  243(20): 5280-8

4:  Mui MM, Elliott WH.
Comparison of 12alpha-hydroxylation of oxygenated 5alpha-cholestanes and allochenodeoxycholate with rat liver microsomes.
Biochemistry.    impact factor:   4.493
1975;  14(12): 2712-7

5:  Eriksson H, Taylor W, Sjovall J.
Occurrence of sulfated 5alpha-cholanoates in rat bile.
J Lipid Res.    impact factor:   3.394
1978;  19(2): 177-86

 
4Compound ID:491
ASCORBIC ACID
NSC#:8117
NSC#:33832
NSC#:218455

Aldrich#:255564
Aldrich#:58320
Aldrich#:856061
Aldrich#:95209
Aldrich#:95210
Aldrich#:95212
Aldrich#:A0278
Aldrich#:A1417
Aldrich#:A2174
Aldrich#:A4403
Aldrich#:A4544
Aldrich#:A7506
Aldrich#:A92902
Aldrich#:I0502
FDA approved!!!
C6H8O6    176.12



1:  Waters DD, Alderman EL, Hsia J, Howard BV, Cobb FR, Rogers WJ, Ouyang P, Thompson P, Tardif JC, Higginson L, Bittner V, Steffes M, Gordon DJ, Proschan M, Younes N, Verter JI.
Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial.
JAMA.    impact factor:   15.402
2002;  288(19): 2432-40

2:  Laurin D, Foley DJ, Masaki KH, White LR, Launer LJ.
Vitamin E and C supplements and risk of dementia.
JAMA.    impact factor:   15.402
2002;  288(18): 2266-8

3:  Bates CJ.
MRC/BHF Heart Protection Study.
Lancet.    impact factor:   10.197
2002;  360(9347): 1781-2; author reply 1783-4

4:  Violi F, Micheletta F, Iuliano L.
How to select patient candidates for antioxidant treatment?
Circulation.    impact factor:   9.903
2002;  106(24): e195; author reply e195

5:  Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, Harrison DG, Hornig B, Drexler H.
Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase.
Circulation.    impact factor:   9.903
2002;  106(24): 3073-8

 
5Compound ID:521
ATROPINE
NSC#:61808

Aldrich#:11320
Aldrich#:A0132
Aldrich#:A3661
Aldrich#:A9547
Aldrich#:H9002
Aldrich#:S445665
FDA approved!!!
C17H23NO3    289.37



1:  Song P, Sekhon HS, Jia Y, Keller JA, Blusztajn JK, Mark GP, Spindel ER.
Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma.
Cancer Res.    impact factor:   8.614
2003;  63(1): 214-21

2:  Mourier G, Dutertre S, Fruchart-Gaillard C, Menez A, Servent D.
Chemical synthesis of MT1 and MT7 muscarinic toxins: critical role of Arg-34 in their interaction with M1 muscarinic receptor.
Mol Pharmacol.    impact factor:   5.465
2003;  63(1): 26-35

3:  Ghelardini C, Galeotti N, Calvani M, Mosconi L, Nicolai R, Bartolini A.
Acetyl-l-carnitine induces muscarinic antinocieption in mice and rats.
Neuropharmacology.    impact factor:   4.176
2002;  43(7): 1180-7

4:  Zhang L, Warren RA.
Muscarinic and Nicotinic Presynaptic Modulation of EPSCs in the Nucleus Accumbens During Postnatal Development.
J Neurophysiol.    impact factor:   3.935
2002;  88(6): 3315-30

5:  Nunez A, Rodrigo-Angulo ML, De Andres I, Reinoso-Suarez F.
Firing activity and postsynaptic properties of morphologically identified neurons of ventral oral pontine reticular nucleus.
Neuroscience.    impact factor:   3.924
2002;  115(4): 1165-75

 
6Compound ID:605
BENZYL BENZOATE
NSC#:8081

Aldrich#:12390
Aldrich#:12392
Aldrich#:84260
Aldrich#:B17700
Aldrich#:B6630
FDA approved!!!
C14H12O2    212.25



1:  Grun F, Venkatesan RN, Tabb MM, Zhou C, Cao J, Hemmati D, Blumberg B.
Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors.
J Biol Chem.    impact factor:   7.666
2002;  277(46): 43691-7

2:  Bhunchet E, Wake K.
The portal lobule in rat liver fibrosis: a re-evaluation of the liver unit.
Hepatology.    impact factor:   7.344
1998;  27(2): 481-7

3:  Reckelhoff JF, Zhang H, Srivastava K, Granger JP.
Gender differences in hypertension in spontaneously hypertensive rats: role of androgens and androgen receptor.
Hypertension.    impact factor:   4.913
1999;  34(4 Pt 2): 920-3

4:  D'Auria JC, Chen F, Pichersky E.
Characterization of an acyltransferase capable of synthesizing benzylbenzoate and other volatile esters in flowers and damaged leaves of Clarkia breweri.
Plant Physiol.    impact factor:   4.434
2002;  130(1): 466-76

5:  Song F, Darbeau RW, White EH.
Interception of Deaminatively Generated Benzyl Carbenium Ions by Acetone.
J Org Chem.    impact factor:   3.44
2000;  65(6): 1825-1829

 
7Compound ID:661
BIOTIN
NSC#:63865

Aldrich#:14400
Aldrich#:861642
Aldrich#:B3399
Aldrich#:B4501
Aldrich#:B4639
FDA approved!!!
C10H16N2O3S    244.31



1:  Yolcu ES, Askenasy N, Singh NP, Cherradi SE, Shirwan H.
Cell membrane modification for rapid display of proteins as a novel means of immunomodulation: FasL-decorated cells prevent islet graft rejection.
Immunity.    impact factor:   20.563
2002;  17(6): 795-808

2:  Keppler A, Gendreizig S, Gronemeyer T, Pick H, Vogel H, Johnsson K.
A general method for the covalent labeling of fusion proteins with small molecules in vivo.
Nat Biotechnol.    impact factor:   10.117
2003;  21(1): 86-89

3:  Pagel JM, Hedin N, Subbiah K, Meyer D, Mallet R, Axworthy D, Theodore LJ, Wilbur DS, Matthews DC, Press OW.
A comparison of anti-CD20 and anti-CD45 antibodies for conventional and pretargeted radioimmunotherapy of B-cell lymphomas.
Blood.    impact factor:   8.782
2002;   [e-pub ahead of print]

4:  Bobkova EV, Yan YP, Jordan DB, Kurilla MG, Pompliano DL.
Catalytic properties of mutant 23S ribosomes resistant to oxazolidinones.
J Biol Chem.    impact factor:   7.666
2003;   [e-pub ahead of print]

5:  Laitinen OH, Nordlund HR, Hytonen VP, Uotila ST, Marttila AT, Savolainen J, Airenne KJ, Livnah O, Bayer EA, Wilchek M, Kulomaa MS.
Rational design of an active avidin monomer.
J Biol Chem.    impact factor:   7.666
2002;   [e-pub ahead of print]

 
8Compound ID:786
CAFFEINE
NSC#:5036

Aldrich#:27600
Aldrich#:27602
Aldrich#:485365
Aldrich#:A010
Aldrich#:C0750
Aldrich#:C1778
Aldrich#:C53
Aldrich#:C6035
FDA approved!!!
C8H10N4O2    194.19



1:  Leitzmann MF, Stampfer MJ, Willett WC, Spiegelman D, Colditz GA, Giovannucci EL.
Coffee intake is associated with lower risk of symptomatic gallstone disease in women.
Gastroenterology.    impact factor:   12.182
2002;  123(6): 1823-30

2:  Bruton JD, Lemmens R, Shi CL, Persson-Sjogren S, Westerblad H, Ahmed M, Pyne NJ, Frame M, Furman BL, Islam MS.
Ryanodine receptors of pancreatic beta-cells mediate a distinct context-dependent signal for insulin secretion.
FASEB J.    impact factor:   11.88
2002;   [e-pub ahead of print]

3:  van Dam RM, Feskens EJ.
Coffee consumption and risk of type 2 diabetes mellitus.
Lancet.    impact factor:   10.197
2002;  360(9344): 1477-8

4:  Corti R, Binggeli C, Sudano I, Spieker L, Hanseler E, Ruschitzka F, Chaplin WF, Luscher TF, Noll G.
Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content: role of habitual versus nonhabitual drinking.
Circulation.    impact factor:   9.903
2002;  106(23): 2935-40

5:  Heffernan TP, Simpson DA, Frank AR, Heinloth AN, Paules RS, Cordeiro-Stone M, Kaufmann WK.
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.
Mol Cell Biol.    impact factor:   9.866
2002;  22(24): 8552-61

 
9Compound ID:895
BETA-CAROTENE
Activity Tested(uM): 19.54

NSC#:62794 Cell Data(>1uM)

Aldrich#:22040
Aldrich#:855553
Aldrich#:C0126
Aldrich#:C9750
FDA approved!!!

C40H56    536.88



1:  Greenwald P.
beta-Carotene and Lung Cancer: A Lesson for Future Chemoprevention Investigations?
J Natl Cancer Inst.    impact factor:   12.945
2003;  95(1): E1

2:  Warnholtz A, Mollnau H, Heitzer T, Kontush A, Moller-Bertram T, Lavall D, Giaid A, Beisiegel U, Marklund SL, Walter U, Meinertz T, Munzel T.
Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits.
J Am Coll Cardiol.    impact factor:   7.368
2002;  40(7): 1356-63

3:  Brown BG, Cheung MC, Lee AC, Zhao XQ, Chait A.
Antioxidant vitamins and lipid therapy: end of a long romance?
Arterioscler Thromb Vasc Biol.    impact factor:   5.406
2002;  22(10): 1535-46

4:  Chen J, He J, Hamm L, Batuman V, Whelton PK.
Serum antioxidant vitamins and blood pressure in the United States population.
Hypertension.    impact factor:   4.913
2002;  40(6): 810-6

5:  Kim MK, Sasaki S, Sasazuki S, Okubo S, Hayashi M, Tsugane S.
Lack of long-term effect of vitamin C supplementation on blood pressure.
Hypertension.    impact factor:   4.913
2002;  40(6): 797-803

 
10Compound ID:1008
CHENODEOXYCHOLIC ACID
Activity Tested(uM): 12.05

NSC#:657949 Cell Data(>1uM)
Activity Tested(uM): 25.12

NSC#:657950 Cell Data(>1uM)
NSC#:683769

Aldrich#:224545
Aldrich#:22510
Aldrich#:859109
Aldrich#:94465
Aldrich#:C9377
Aldrich#:U5127
FDA approved!!!

C24H40O4    392.58



1:  Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD.
A natural product that lowers cholesterol as an antagonist ligand for FXR.
Science.    impact factor:   24.595
2002;  296(5573): 1703-6

2:  Jung D, Podvinec M, Meyer UA, Mangelsdorf DJ, Fried M, Meier PJ, Kullak-Ublick GA.
Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor.
Gastroenterology.    impact factor:   12.182
2002;  122(7): 1954-66

3:  Zhang F, Altorki NK, Wu YC, Soslow RA, Subbaramaiah K, Dannenberg AJ.
Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids.
Gastroenterology.    impact factor:   12.182
2001;  121(6): 1391-9

4:  Quattropani C, Vogt B, Odermatt A, Dick B, Frey BM, Frey FJ.
Reduced activity of 11 beta-hydroxysteroid dehydrogenase in patients with cholestasis.
J Clin Invest.    impact factor:   10.921
2001;  108(9): 1299-305

5:  Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA.
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
J Biol Chem.    impact factor:   7.666
2002;  277(4): 2908-15

 

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