List of 100 most frequent compounds occurred in ingredients.
ID Name Structure Top 10 Available References (order by impact factor) Molecular Target(s)
1Compound ID:    5884
frequence:  59
BETA-SITOSTEROL
NSC#:8096
NSC#:18173
NSC#:49083
NSC#:132035
Aldrich#:85449
Aldrich#:85450
Aldrich#:85451
Aldrich#:R202738
Aldrich#:R202797
Aldrich#:S1270
Aldrich#:S3402
Aldrich#:S5753
Aldrich#:S957623
Aldrich#:S9889

C29H50O    414.71



1:  Clouse SD.
Arabidopsis mutants reveal multiple roles for sterols in plant development.
Plant Cell.    impact factor:   10.463
2002;  14(9): 1995-2000

2:  Sudhop T, Sahin Y, Lindenthal B, Hahn C, Luers C, Berthold HK, von Bergmann K.
Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion.
Gut.    impact factor:   5.748
2002;  51(6): 860-3

3:  Holmberg N, Harker M, Gibbard CL, Wallace AD, Clayton JC, Rawlins S, Hellyer A, Safford R.
Sterol C-24 methyltransferase type 1 controls the flux of carbon into sterol biosynthesis in tobacco seed.
Plant Physiol.    impact factor:   4.434
2002;  130(1): 303-11

4:  Warnecke DC, Heinz E.
Purification of a Membrane-Bound UDP-Glucose:Sterol [beta]-D-Glucosyltransferase Based on Its Solubility in Diethyl Ether.
Plant Physiol.    impact factor:   4.434
1994;  105(4): 1067-1073

5:  Fernandez C, Suarez Y, Ferruelo AJ, Gomez-Coronado D, Lasuncion MA.
Inhibition of cholesterol biosynthesis by Delta22-unsaturated phytosterols via competitive inhibition of sterol Delta24-reductase in mammalian cells.
Biochem J.    impact factor:   4.349
2002;  366(Pt 1): 109-19

 
2Compound ID:    6663
frequence:  34
VITAMIN C
NSC#:8117
NSC#:33832
NSC#:218455
Aldrich#:255564
Aldrich#:58320
Aldrich#:856061
Aldrich#:95209
Aldrich#:95210
Aldrich#:95212
Aldrich#:A0278
Aldrich#:A1417
Aldrich#:A2174
Aldrich#:A4403
Aldrich#:A4544
Aldrich#:A7506
Aldrich#:A92902
Aldrich#:I0502
FDA approved!!!

C6H8O6    176.12



1:  Bates CJ.
MRC/BHF Heart Protection Study.
Lancet.    impact factor:   10.197
2002;  360(9347): 1781-2; author reply 1783-4

2:  Violi F, Micheletta F, Iuliano L.
How to select patient candidates for antioxidant treatment?
Circulation.    impact factor:   9.903
2002;  106(24): e195; author reply e195

3:  Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, Harrison DG, Hornig B, Drexler H.
Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase.
Circulation.    impact factor:   9.903
2002;  106(24): 3073-8

4:  Wood NT.
Phloem transport of vitamin C - an alternative route to raising antioxidant levels?
Trends Plant Sci.    impact factor:   9.35
2002;  7(12): 524-5

5:  D'Uscio LV, Milstien S, Richardson D, Smith L, Katusic ZS.
Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity.
Circ Res.    impact factor:   8.281
2003;  92(1): 88-95

 
3Compound ID:    6658
frequence:  23
THIAMINE
FDA approved!!!

C12H17ClN4OS    300.81



1:  Szostak JW.
Molecular biology: RNA gets a grip on translation.
Nature.    impact factor:   29.491
2002;  419(6910): 890-1

2:  Winkler W, Nahvi A, Breaker RR.
Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression.
Nature.    impact factor:   29.491
2002;  419(6910): 952-6

3:  Harvey SC.
Insect repellents and mosquito bites.
N Engl J Med.    impact factor:   28.857
2002;  347(21): 1719-21; author reply 1719-21

4:  Marobbio CM, Vozza A, Harding M, Bisaccia F, Palmieri F, Walker JE.
Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate.
EMBO J.    impact factor:   13.973
2002;  21(21): 5653-61

5:  Hesselberth JR, Ellington AD.
A (ribo) switch in the paradigms of genetic regulation.
Nat Struct Biol.    impact factor:   13.555
2002;  9(12): 891-3

 
4Compound ID:    3914
frequence:  22
LINOLEIC ACID
NSC#:24184
NSC#:281243
Aldrich#:233927
Aldrich#:62230
Aldrich#:62235
Aldrich#:62240
Aldrich#:L1012
Aldrich#:L1268
Aldrich#:L1376
Aldrich#:L1626

C18H32O2    280.45



1:  Riserus U, Basu S, Jovinge S, Fredrikson GN, Arnlov J, Vessby B.
Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance.
Circulation.    impact factor:   9.903
2002;  106(15): 1925-9

2:  Dyer JM, Chapital DC, Kuan JC, Mullen RT, Turner C, McKeon TA, Pepperman AB.
Molecular analysis of a bifunctional Fatty Acid conjugase/desaturase from tung. Implications for the evolution of plant Fatty Acid diversity.
Plant Physiol.    impact factor:   4.434
2002;  130(4): 2027-38

3:  Castro H, Budde H, Flohe L, Hofmann B, Lunsdorf H, Wissing J, Tomas AM.
Specificity and kinetics of a mitochondrial peroxiredoxin of Leishmania infantum.
Free Radic Biol Med.    impact factor:   4.116
2002;  33(11): 1563-74

4:  Freese R, Alfthan G, Jauhiainen M, Basu S, Erlund I, Salminen I, Aro A, Mutanen M.
High intakes of vegetables, berries, and apples combined with a high intake of linoleic or oleic acid only slightly affect markers of lipid peroxidation and lipoprotein metabolism in healthy subjects.
Am J Clin Nutr.    impact factor:   3.958
2002;  76(5): 950-60

5:  McKellar ME, Nelson EB.
Compost-induced suppression of pythium damping-off is mediated by Fatty-Acid-metabolizing seed-colonizing microbial communities.
Appl Environ Microbiol.    impact factor:   3.541
2003;  69(1): 452-60

 
5Compound ID:    5439
frequence:  22
QUERCETIN
NSC#:9219
NSC#:57655
NSC#:58588
Aldrich#:83370
Aldrich#:S102725
Aldrich#:S98702

C15H10O7    302.24



1:  Roger A, Rubira N, Nogueiras C, Guspi R, Baltasar M, Cadahia A.
[Anaphylaxis caused by royal jelly]
Allergol Immunopathol (Madr).    impact factor:   0
1995;  23(3): 133-5

 
6Compound ID:    4842
frequence:  18
CARYOPHYLLIN
NSC#:4060
NSC#:114945
NSC#:167406
Aldrich#:301701
Aldrich#:301728
Aldrich#:O5504
Aldrich#:U6753

C30H48O3    456.71



no reference available. 
7Compound ID:    6657
frequence:  18
VITAMIN A
NSC#:122759(<1uM)
Aldrich#:223026
Aldrich#:95144
Aldrich#:95146
Aldrich#:R7632
FDA approved!!!

C20H30O    286.46



1:  Guillemin MC, Raffoux E, Vitoux D, Kogan S, Soilihi H, Lallemand-Breitenbach V, Zhu J, Janin A, Daniel MT, Gourmel B, Degos L, Dombret H, Lanotte M, De The H.
In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia.
J Exp Med.    impact factor:   15.651
2002;  196(10): 1373-80

2:  Ozbek S, Engel J, Stetefeld J.
Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3).
EMBO J.    impact factor:   13.973
2002;  21(22): 5960-8

3:  Weiger WA, Smith M, Boon H, Richardson MA, Kaptchuk TJ, Eisenberg DM.
Advising patients who seek complementary and alternative medical therapies for cancer.
Ann Intern Med.    impact factor:   10.097
2002;  137(11): 889-903

4:  Lee MY, Jung CH, Lee K, Choi YH, Hong S, Cheong J.
Activating transcription factor-2 mediates transcriptional regulation of gluconeogenic gene PEPCK by retinoic acid.
Diabetes.    impact factor:   9.019
2002;  51(12): 3400-7

5:  Varani J, Perone P, Merfert MG, Moon SE, Larkin D, Stevens MJ.
All-trans retinoic acid improves structure and function of diabetic rat skin in organ culture.
Diabetes.    impact factor:   9.019
2002;  51(12): 3510-6

 
8Compound ID:    4951
frequence:  16
PALMITIC ACID
NSC#:470
NSC#:5030
NSC#:115894
Aldrich#:258725
Aldrich#:292125
Aldrich#:464449
Aldrich#:485802
Aldrich#:492752
Aldrich#:76119
Aldrich#:76120
Aldrich#:76122
Aldrich#:M3414
Aldrich#:M6781
Aldrich#:P0500
Aldrich#:P0625
Aldrich#:P1076
Aldrich#:P51
Aldrich#:P8575

C16H32O2    256.43



1:  Brown AJ, Sun L, Feramisco JD, Brown MS, Goldstein JL.
Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism.
Mol Cell.    impact factor:   18.142
2002;  10(2): 237-45

2:  Le Stunff H, Galve-Roperh I, Peterson C, Milstien S, Spiegel S.
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis.
J Cell Biol.    impact factor:   12.88
2002;  158(6): 1039-49

3:  Roth AF, Feng Y, Chen L, Davis NG.
The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase.
J Cell Biol.    impact factor:   12.88
2002;  159(1): 23-8

4:  Bunnell SC, Hong DI, Kardon JR, Yamazaki T, McGlade CJ, Barr VA, Samelson LE.
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies.
J Cell Biol.    impact factor:   12.88
2002;  158(7): 1263-75

5:  Nybakken K, Perrimon N.
Hedgehog signal transduction: recent findings.
Curr Opin Genet Dev.    impact factor:   12.665
2002;  12(5): 503-11

 
9Compound ID:    4848
frequence:  16
OLEIC ACID
NSC#:9856
NSC#:26988
NSC#:65522
NSC#:112237
NSC#:112238
Aldrich#:268046
Aldrich#:364525
Aldrich#:45089
Aldrich#:45090
Aldrich#:490423
Aldrich#:490431
Aldrich#:75090
Aldrich#:75092
Aldrich#:75093
Aldrich#:75096
Aldrich#:E304
Aldrich#:E4637
Aldrich#:O1008
Aldrich#:O1383
Aldrich#:O1508
Aldrich#:O1630

C18H34O2    282.46



1:  Harper ME, Antoniou A, Villalobos-Menuey E, Russo A, Trauger R, Vendemelio M, George A, Bartholomew R, Carlo D, Shaikh A, Kupperman J, Newell EW, Bespalov IA, Wallace SS, Liu Y, Rogers JR, Gibbs GL, Leahy JL, Camley RE, Melamede R, Newell MK.
Characterization of a novel metabolic strategy used by drug-resistant tumor cells.
FASEB J.    impact factor:   11.88
2002;  16(12): 1550-7

2:  Doolan GK, Panchal RG, Fonnes EL, Clarke AL, Williams DA, Petrou S.
Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK.
FASEB J.    impact factor:   11.88
2002;  16(12): 1662-4

3:  Lanza GM, Yu X, Winter PM, Abendschein DR, Karukstis KK, Scott MJ, Chinen LK, Fuhrhop RW, Scherrer DE, Wickline SA.
Targeted antiproliferative drug delivery to vascular smooth muscle cells with a magnetic resonance imaging nanoparticle contrast agent: implications for rational therapy of restenosis.
Circulation.    impact factor:   9.903
2002;  106(22): 2842-7

4:  Gomez R, Navarro M, Ferrer B, Trigo JM, Bilbao A, Del Arco I, Cippitelli A, Nava F, Piomelli D, Rodriguez de Fonseca F.
A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding.
J Neurosci.    impact factor:   8.955
2002;  22(21): 9612-7

5:  Litvak V, Shaul YD, Shulewitz M, Amarilio R, Carmon S, Lev S.
Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain.
Curr Biol.    impact factor:   8.733
2002;  12(17): 1513-8

 
10Compound ID:    1034
frequence:  15
CHOLINE
NSC#:293906
NSC#:402838
Aldrich#:C1379
Aldrich#:C4917
Aldrich#:C9154

C5H14NO    104.17



1:  Jacobs S.
An oral drug for leishmaniasis.
N Engl J Med.    impact factor:   28.857
2002;  347(22): 1737-8

2:  Sundar S, Jha TK, Thakur CP, Engel J, Sindermann H, Fischer C, Junge K, Bryceson A, Berman J.
Oral miltefosine for Indian visceral leishmaniasis.
N Engl J Med.    impact factor:   28.857
2002;  347(22): 1739-46

3:  Murray HW.
Kala-azar--progress against a neglected disease.
N Engl J Med.    impact factor:   28.857
2002;  347(22): 1793-4

4:  Babapulle MN, Eisenberg MJ.
Coated stents for the prevention of restenosis: Part II.
Circulation.    impact factor:   9.903
2002;  106(22): 2859-66

5:  Buttini M, Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L.
Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.
J Neurosci.    impact factor:   8.955
2002;  22(24): 10539-48

 

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