| ID |
Name |
Structure |
Top 10 Available References (order by impact factor) |
Molecular Target(s) |
| 1 | Compound ID: 5884
frequence: 298
BETA-SITOSTEROL
NSC#:8096
NSC#:18173
NSC#:49083
NSC#:132035
Aldrich#:85449
Aldrich#:85450
Aldrich#:85451
Aldrich#:R202738
Aldrich#:R202797
Aldrich#:S1270
Aldrich#:S3402
Aldrich#:S5753
Aldrich#:S957623
Aldrich#:S9889
|
C29H50O 414.71
| 1: Clouse SD.
Arabidopsis mutants reveal multiple roles for sterols in plant development.
Plant Cell. impact factor: 10.463
2002; 14(9): 1995-2000
2: Sudhop T, Sahin Y, Lindenthal B, Hahn C, Luers C, Berthold HK, von Bergmann K.
Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion.
Gut. impact factor: 5.748
2002; 51(6): 860-3
3: Holmberg N, Harker M, Gibbard CL, Wallace AD, Clayton JC, Rawlins S, Hellyer A, Safford R.
Sterol C-24 methyltransferase type 1 controls the flux of carbon into sterol biosynthesis in tobacco seed.
Plant Physiol. impact factor: 4.434
2002; 130(1): 303-11
4: Warnecke DC, Heinz E.
Purification of a Membrane-Bound UDP-Glucose:Sterol [beta]-D-Glucosyltransferase Based on Its Solubility in Diethyl Ether.
Plant Physiol. impact factor: 4.434
1994; 105(4): 1067-1073
5: Fernandez C, Suarez Y, Ferruelo AJ, Gomez-Coronado D, Lasuncion MA.
Inhibition of cholesterol biosynthesis by Delta22-unsaturated phytosterols via competitive inhibition of sterol Delta24-reductase in mammalian cells.
Biochem J. impact factor: 4.349
2002; 366(Pt 1): 109-19
| |
| 2 | Compound ID: 6663
frequence: 230
VITAMIN C
NSC#:8117
NSC#:33832
NSC#:218455
Aldrich#:255564
Aldrich#:58320
Aldrich#:856061
Aldrich#:95209
Aldrich#:95210
Aldrich#:95212
Aldrich#:A0278
Aldrich#:A1417
Aldrich#:A2174
Aldrich#:A4403
Aldrich#:A4544
Aldrich#:A7506
Aldrich#:A92902
Aldrich#:I0502
FDA approved!!!
|
C6H8O6 176.12
| 1: Bates CJ.
MRC/BHF Heart Protection Study.
Lancet. impact factor: 10.197
2002; 360(9347): 1781-2; author reply 1783-4
2: Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, Harrison DG, Hornig B, Drexler H.
Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase.
Circulation. impact factor: 9.903
2002; 106(24): 3073-8
3: Violi F, Micheletta F, Iuliano L.
How to select patient candidates for antioxidant treatment?
Circulation. impact factor: 9.903
2002; 106(24): e195; author reply e195
4: Wood NT.
Phloem transport of vitamin C - an alternative route to raising antioxidant levels?
Trends Plant Sci. impact factor: 9.35
2002; 7(12): 524-5
5: D'Uscio LV, Milstien S, Richardson D, Smith L, Katusic ZS.
Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity.
Circ Res. impact factor: 8.281
2003; 92(1): 88-95
| |
| 3 | Compound ID: 4842
frequence: 215
CARYOPHYLLIN
NSC#:4060
NSC#:114945
NSC#:167406
Aldrich#:301701
Aldrich#:301728
Aldrich#:O5504
Aldrich#:U6753
|
C30H48O3 456.71
| no reference available. | |
| 4 | Compound ID: 6658
frequence: 213
THIAMINE
FDA approved!!!
|
C12H17ClN4OS 300.81
| 1: Winkler W, Nahvi A, Breaker RR.
Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression.
Nature. impact factor: 29.491
2002; 419(6910): 952-6
2: Szostak JW.
Molecular biology: RNA gets a grip on translation.
Nature. impact factor: 29.491
2002; 419(6910): 890-1
3: Harvey SC.
Insect repellents and mosquito bites.
N Engl J Med. impact factor: 28.857
2002; 347(21): 1719-21; author reply 1719-21
4: Marobbio CM, Vozza A, Harding M, Bisaccia F, Palmieri F, Walker JE.
Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate.
EMBO J. impact factor: 13.973
2002; 21(21): 5653-61
5: Hesselberth JR, Ellington AD.
A (ribo) switch in the paradigms of genetic regulation.
Nat Struct Biol. impact factor: 13.555
2002; 9(12): 891-3
| |
| 5 | Compound ID: 6657
frequence: 190
VITAMIN A
NSC#:122759(<1uM)
Aldrich#:223026
Aldrich#:95144
Aldrich#:95146
Aldrich#:R7632
FDA approved!!!
|
C20H30O 286.46
| 1: Guillemin MC, Raffoux E, Vitoux D, Kogan S, Soilihi H, Lallemand-Breitenbach V, Zhu J, Janin A, Daniel MT, Gourmel B, Degos L, Dombret H, Lanotte M, De The H.
In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia.
J Exp Med. impact factor: 15.651
2002; 196(10): 1373-80
2: Ozbek S, Engel J, Stetefeld J.
Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3).
EMBO J. impact factor: 13.973
2002; 21(22): 5960-8
3: Weiger WA, Smith M, Boon H, Richardson MA, Kaptchuk TJ, Eisenberg DM.
Advising patients who seek complementary and alternative medical therapies for cancer.
Ann Intern Med. impact factor: 10.097
2002; 137(11): 889-903
4: Lee MY, Jung CH, Lee K, Choi YH, Hong S, Cheong J.
Activating transcription factor-2 mediates transcriptional regulation of gluconeogenic gene PEPCK by retinoic acid.
Diabetes. impact factor: 9.019
2002; 51(12): 3400-7
5: Varani J, Perone P, Merfert MG, Moon SE, Larkin D, Stevens MJ.
All-trans retinoic acid improves structure and function of diabetic rat skin in organ culture.
Diabetes. impact factor: 9.019
2002; 51(12): 3510-6
| |
| 6 | Compound ID: 1290
frequence: 168
P-COUMARIC ACID
NSC#:59260
NSC#:674321
Aldrich#:28200
Aldrich#:C9008
Aldrich#:H23201
|
C9H8O3 164.16
| 1: Schoch G, Goepfert S, Morant M, Hehn A, Meyer D, Ullmann P, Werck-Reichhart D.
CYP98A3 from Arabidopsis thaliana is a 3'-hydroxylase of phenolic esters, a missing link in the phenylpropanoid pathway.
J Biol Chem. impact factor: 7.666
2001; 276(39): 36566-74
2: Lee BC, Croonquist PA, Hoff WD.
Mimic of photocycle by a protein folding reaction in photoactive yellow protein.
J Biol Chem. impact factor: 7.666
2001; 276(48): 44481-7
3: Suzuki H, Nakayama T, Yonekura-Sakakibara K, Fukui Y, Nakamura N, Nakao M, Tanaka Y, Yamaguchi MA, Kusumi T, Nishino T.
Malonyl-CoA:anthocyanin 5-O-glucoside-6"'-O-malonyltransferase from scarlet sage (Salvia splendens) flowers. Enzyme purification, gene cloning, expression, and characterization.
J Biol Chem. impact factor: 7.666
2001; 276(52): 49013-9
4: Franke R, Hemm MR, Denault JW, Ruegger MO, Humphreys JM, Chapple C.
Changes in secondary metabolism and deposition of an unusual lignin in the ref8 mutant of Arabidopsis.
Plant J. impact factor: 5.09
2002; 30(1): 47-59
5: Unno M, Kumauchi M, Sasaki J, Tokunaga F, Yamauchi S.
Resonance Raman spectroscopy and quantum chemical calculations reveal structural changes in the active site of photoactive yellow protein.
Biochemistry. impact factor: 4.493
2002; 41(17): 5668-74
| |
| 7 | Compound ID: 3914
frequence: 155
LINOLEIC ACID
NSC#:24184
NSC#:281243
Aldrich#:233927
Aldrich#:62230
Aldrich#:62235
Aldrich#:62240
Aldrich#:L1012
Aldrich#:L1268
Aldrich#:L1376
Aldrich#:L1626
|
C18H32O2 280.45
| 1: Riserus U, Basu S, Jovinge S, Fredrikson GN, Arnlov J, Vessby B.
Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance.
Circulation. impact factor: 9.903
2002; 106(15): 1925-9
2: Dyer JM, Chapital DC, Kuan JC, Mullen RT, Turner C, McKeon TA, Pepperman AB.
Molecular analysis of a bifunctional Fatty Acid conjugase/desaturase from tung. Implications for the evolution of plant Fatty Acid diversity.
Plant Physiol. impact factor: 4.434
2002; 130(4): 2027-38
3: Castro H, Budde H, Flohe L, Hofmann B, Lunsdorf H, Wissing J, Tomas AM.
Specificity and kinetics of a mitochondrial peroxiredoxin of Leishmania infantum.
Free Radic Biol Med. impact factor: 4.116
2002; 33(11): 1563-74
4: Freese R, Alfthan G, Jauhiainen M, Basu S, Erlund I, Salminen I, Aro A, Mutanen M.
High intakes of vegetables, berries, and apples combined with a high intake of linoleic or oleic acid only slightly affect markers of lipid peroxidation and lipoprotein metabolism in healthy subjects.
Am J Clin Nutr. impact factor: 3.958
2002; 76(5): 950-60
5: McKellar ME, Nelson EB.
Compost-induced suppression of pythium damping-off is mediated by Fatty-Acid-metabolizing seed-colonizing microbial communities.
Appl Environ Microbiol. impact factor: 3.541
2003; 69(1): 452-60
| |
| 8 | Compound ID: 2356
frequence: 151
FERULIC ACID
NSC#:2821
NSC#:51986
NSC#:674320
Aldrich#:128708
Aldrich#:46278
Aldrich#:46280
Aldrich#:F3500
|
C10H10O4 194.19
| 1: Zubieta C, Kota P, Ferrer JL, Dixon RA, Noel JP.
Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase.
Plant Cell. impact factor: 10.463
2002; 14(6): 1265-77
2: Oudgenoeg G, Dirksen E, Ingemann S, Hilhorst R, Gruppen H, Boeriu CG, Piersma SR, van Berkel WJ, Laane C, Voragen AG.
Horseradish peroxidase-catalyzed oligomerization of ferulic acid on a template of a tyrosine-containing tripeptide.
J Biol Chem. impact factor: 7.666
2002; 277(24): 21332-40
3: Ndong C, Anzellotti D, Ibrahim RK, Huner NP, Sarhan F.
Daphnetin methylation by a novel O-methyltransferase is associated with cold acclimation and PSII excitation pressure in rye.
J Biol Chem. impact factor: 7.666
2002; [e-pub ahead of print]
4: Nair RB, Xia Q, Kartha CJ, Kurylo E, Hirji RN, Datla R, Selvaraj G.
Arabidopsis CYP98A3 mediating aromatic 3-hydroxylation. Developmental regulation of the gene, and expression in yeast.
Plant Physiol. impact factor: 4.434
2002; 130(1): 210-20
5: Harding SA, Leshkevich J, Chiang VL, Tsai CJ.
Differential substrate inhibition couples kinetically distinct 4-coumarate:coenzyme a ligases with spatially distinct metabolic roles in quaking aspen.
Plant Physiol. impact factor: 4.434
2002; 128(2): 428-38
| |
| 9 | Compound ID: 6006
frequence: 150
STIGMASTEROL
Aldrich#:R202924
|
C29H48O 412.7
| 1: Osman H, Vauthrin S, Mikes V, Milat ML, Panabieres F, Marais A, Brunie S, Maume B, Ponchet M, Blein JP.
Mediation of elicitin activity on tobacco is assumed by elicitin-sterol complexes.
Mol Biol Cell. impact factor: 7.527
2001; 12(9): 2825-34
2: Hishiya T, Asanuma H, Komiyama M.
Spectroscopic anatomy of molecular-imprinting of cyclodextrin. Evidence for preferential formation of ordered cyclodextrin assemblies.
J Am Chem Soc. impact factor: 5.537
2002; 124(4): 570-5
3: Khabazian I, Bains JS, Williams DE, Cheung J, Wilson JM, Pasqualotto BA, Pelech SL, Andersen RJ, Wang YT, Liu L, Nagai A, Kim SU, Craig UK, Shaw CA.
Isolation of various forms of sterol beta-D-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS-parkinsonism dementia complex.
J Neurochem. impact factor: 4.906
2002; 82(3): 516-28
4: Rapaport H, Kuzmenko I, Lafont S, Kjaer K, Howes PB, Als-Nielsen J, Lahav M, Leiserowitz L.
Cholesterol monohydrate nucleation in ultrathin films on water.
Biophys J. impact factor: 4.58
2001; 81(5): 2729-36
5: Holmberg N, Harker M, Gibbard CL, Wallace AD, Clayton JC, Rawlins S, Hellyer A, Safford R.
Sterol C-24 methyltransferase type 1 controls the flux of carbon into sterol biosynthesis in tobacco seed.
Plant Physiol. impact factor: 4.434
2002; 130(1): 303-11
| |
| 10 | Compound ID: 1034
frequence: 149
CHOLINE
NSC#:293906
NSC#:402838
Aldrich#:C1379
Aldrich#:C4917
Aldrich#:C9154
|
C5H14NO 104.17
| 1: Murray HW.
Kala-azar--progress against a neglected disease.
N Engl J Med. impact factor: 28.857
2002; 347(22): 1793-4
2: Jacobs S.
An oral drug for leishmaniasis.
N Engl J Med. impact factor: 28.857
2002; 347(22): 1737-8
3: Sundar S, Jha TK, Thakur CP, Engel J, Sindermann H, Fischer C, Junge K, Bryceson A, Berman J.
Oral miltefosine for Indian visceral leishmaniasis.
N Engl J Med. impact factor: 28.857
2002; 347(22): 1739-46
4: Babapulle MN, Eisenberg MJ.
Coated stents for the prevention of restenosis: Part II.
Circulation. impact factor: 9.903
2002; 106(22): 2859-66
5: Kim J, Isokawa M, Ledent C, Alger BE.
Activation of muscarinic acetylcholine receptors enhances the release of endogenous cannabinoids in the hippocampus.
J Neurosci. impact factor: 8.955
2002; 22(23): 10182-91
| |