ID Short Name Description
and NCI 60 Expression Level
(protein or mRNA)
Pathway Weizmann Gene Card
1 ABL ABL (proto-oncogene tyrosine-protein kinase) Abl1 is a tyrosine-protein kinase and a homolog of the v-abl Abelson murine leukemia viral oncogene. ABL
2 ACK2 ACK2 (tyrosine-protein kinase) null null
3 ALK ALK (anaplastic lymphoma tyrosine kinase Ki-1) Anaplastic lymphoma kinase (Alk) is involved in a common translocation in non-Hodgkin's lymphoma. ALK
4 ARG ARG (tyrosine-protein kinase) Arg is a tyrosine-protein kinase and a homolog of the v-abl Abelson murine leukemia viral oncogene. ABL2
5 AXL AXL (receptor tyrosine kinase) Axl is a receptor tyrosine kinase and may be involved in the protection of neurons from apoptosis. AXL
6 Bad Bad (BCL2-antagonist of cell death) BAD promotes cell death by competing for the binding to bcl-x(l) and bcl-2. BAD
7 Bas BAS (protein tyrosine phosphatase) PTP-BAS is a non-receptor-type protein tyrosine phosphatase. PTPN13
8 Bax 1 Bax (BCL2-associated X protein) 1 BAX accelerates apoptosis by binding to, and antagonizing the apoptosis repressor bcl-2. BAX is mutated in certain tumors. BAX
9 Bax 2 Bax (BCL2-associated X protein) 2 BAX accelerates apoptosis by binding to, and antagonizing the apoptosis repressor bcl-2. BAX is mutated in certain tumors. BAX
10 Bcl-2 Bcl-2 (Apoptosis regulator) null BCL2
11 Bcl-xl Bcl-xl (BCL2-like 1) Bcl-xl is a dominant regulator of apoptotic cell death. BCL2L1
12 Bcl-xl basal level Bcl-xl (BCL2-like 1)basal levels Bcl-xL may be dominant regulator of apoptotic cell death, with the long form displaying cell death repressor activity. BCL2L1
13 BDP1 BDP1 (tyrosine phosphatase) Brain Derived Phosphatase (BDP1) is a protein tyrosine phosphatase, with greatest homology with members of the PTP-PEST family. PTPN18
14 Blk Blk (B lymphoid tyrosine kinase) B lymphoid tyrosine kinase (Blk) is a member of the Src family. BLK
15 BMX BMX (non-receptor tyrosine kinase) Bmx (Bone marrow kinase, X-linked) is a cytoplasmic tyrosine-protein kinase with a possible role in the growth and differentiation of hematopoietic cells. BMX
16 BRK BRK (Protein tyrosine kinase 6) Brk (protein tyrosine kinase 6) is a non-receptor type protein tyrosine kinase. PTK6
17 BTK BTK (Bruton agammaglobulinemia tyrosine kinase) Bruton agammaglobulinemia tyrosine kinase may have a role in B-cell development. Defects in BTK are the cause of X-linked agammaglobulinemia type 1. BTK
18 c-iap1 c-iap1 (mRNA level apoptosis inhibitor 2) c-iap1 is an inhibitor of apoptosis. BIRC2
20 c-iap2 c-iap2 (mRNA level apoptosis inhibitor 1) c-iap2 is an inhibitor of apoptosis. BIRC3
21 c-Myc c-Myc (basic helix-loop-helix transcription factor family) Myc is a transcription factor. Overexpression of c-myc has been implicated in the etiology of a variety of hematopoietic tumors. MYC
22 Carcinoembryonic antigen Carcinoembryonic antigen The solid tumor lines were characterized individually using immunocytochemical techniques to determine their relative degrees of representativity for the subpanels within which they are grouped. CEACAM5
23 CCK4 CCK4 (tyrosine kinase) Human colon carcinoma kinase-4, CCK4 (PTK7), may be a tumor progession marker. PTK7
24 CD45 CD45 (protein tyrosine phosphatase, receptor type) Leukocyte antigen CD45 is a receptor type protein tyrosine phosphatase with a possible role in T-cell activation. PTPRC
25 cIAP1 cIAP1 (apoptosis inhibitor) cIAP1 is an inhibitor of apoptosis that may interact with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2). BIRC2
26 Class-3 aldehyde dehydrogenase Class-3 aldehyde dehydrogenase Aldehyde dehydrogenase detoxifies a class of nitrogen mustards, the oxazaphosphorines. It is present in many normal cells, but absent from certain tumor cells. ALDH3A1
27 Class-I aldehyde dehydrogenase Class-I aldehyde dehydrogenase Aldehyde dehydrogenase detoxifies a class of nitrogen mustards, the oxazaphosphorines. It is present in many normal cells, but absent from certain tumor cells. ALDH1A1
28 CSF1R CSF1R (csf-1receptor, a protein tyrosine-kinase)
Colony stimulating factor 1 receptor is a protein tyrosine-kinase transmembrane receptor.
CSF1R
29 CSK CSK (c-src tyrosine kinase) c-src tyrosine kinase phosphorylates a tyrosine residue on c-src which acts as a negative regulatory site. CSK
30 CTK CTK (megakaryocyte-associated tyrosine kinase) Megakaryocyte-associated tyrosine kinase belongs to the CSK subfamily. MATK
31 Cytochrome B5 reductase Cytochrome B5 reductase Many antitumor drugs require metabolic activation, catalyzed by reductase enzymes, to exert their cytotoxic or cytostatic effects. DIA1
32 Cytochrome P450 7-Benzyloxyresorufin dealkylation  Cytochrome P450 7-Benzyloxyresorufin dealkylation (Waxman) Many antitumor drugs either undergo P450 enzyme-catalyzed metabolism leading to drug inactivation, or in some cases require metabolic activation catalyzed by P450 enzymes, to exert their cytotoxic or cytostatic effects null
33 Cytochrome P450 7-Ethoxycoumarin 0-deethylase Cytochrome P450 7-Ethoxycoumarin 0-deethylase (Waxman) Many antitumor drugs either undergo P450 enzyme-catalyzed metabolism leading to drug inactivation, or in some cases require metabolic activation catalyzed by P450 enzymes, to exert their cytotoxic or cytostatic effects. null
34 Cytochrome P450 7-ethoxyresorufin deethylase Cytochrome P450 7-ethoxyresorufin deethylase (Waxman) Many antitumor drugs either undergo P450 enzyme-catalyzed metabolism leading to drug inactivation, or in some cases require metabolic activation catalyzed by P450 enzymes, to exert their cytotoxic or cytostatic effects. null
35 Cytochrome P450 Coumarin hydroxylase Cytochrome P450 Coumarin hydroxylase (Waxman) Many antitumor drugs either undergo P450 enzyme-catalyzed metabolism leading to drug inactivation, or in some cases require metabolic activation catalyzed by P450 enzymes, to exert their cytotoxic or cytostatic effects. null
36 Cytochrome P450 reductase Cytochrome P450 reductase Many antitumor drugs require metabolic activation, catalyzed by reductase enzymes, to exert their cytotoxic or cytostatic effects. POR
37 DDR DDR (discoidin domain receptor tyrosine kinase) Discoidin domain receptor tyrosine kinases may be activated by collagen. DDR1 DDR2
38 DEP-1 DEP-1 (protein tyrosine phosphatase, receptor type) Dep-1 is a receptor-type protein-tyrosine phosphatase which may be involved in inhibition of cell growth. PTPRJ
39 Desmin 56kD Desmin 56kD The solid tumor lines were characterized individually using immunocytochemical techniques to determine their relative degrees of representativity for the subpanels within which they are grouped. DES
40 Dihydrodiol dehydrogenase Dihydrodiol dehydrogenase Dihydrodiol dehydrogenase catalyzes the detoxification of polycyclic aromatic hydrocarbons and organochloride pesticides. AKR1C1
AKR1C2
AKR1C3
AKR1C4
41 Dihydropyrimidine dehydrogenase Dihydropyrimidine dehydrogenase Dihydropyrimidine dehydrogenase is involved in pyrimidine catabolism. It catalyzes the reduction of uracil and thymine and may also be involved the degradation of the chemotherapeutic drug 5-fluorouracil. DPYD
42 DT diaphorase DT diaphorase Many antitumor drugs require metabolic activation, catalyzed by reductase enzymes, to exert their cytotoxic or cytostatic effects. NQO1
43 EphA1 EphA1 (ephrin receptor, tyrosine kinase) EphA1 is a receptor for members of the ephrin-a family (binds with low affinity to ephrin-a1) and is a protein tyrosine kinase. EPHA1
44 EphA2 EphA2 (ephrin receptor, tyrosine kinase) EphA2 is a receptor for members of the ephrin-a family (binds to ephrin-a1, -a3, -a4 and -a5) and is a protein tyrosine kinase. EPHA2
45 EphA3 EphA3 (ephrin receptor, tyrosine kinase) EphA3 is a receptor for members of the ephrin-a family (binds to ephrin-a2, -a3, -a4 and -a5) and is a protein tyrosine kinase. EPHA3
46 EphA4 EphA4 (ephrin receptor, tyrosine kinase) EphA4 is a receptor for members of the ephrin-a family (binds to ephrin-a1, -a4 and -a5, and more poorly to ephrin-a2 and a-3) and is a protein tyrosine kinase. EPHA4
47 EphA5 EphA5 (ephrin receptor, tyrosine kinase) EphA5 is a receptor for members of the ephrin-a family (binds to ephrin-a1, -a2, -a3, -a4 and -a5) and is a protein tyrosine kinase. EPHA5
48 EPhA6 EphA6 (ephrin receptor, tyrosine kinase) EphA6 is a receptor for members of the ephrin-a family. null
49 EphA7 EphA7 (ephrin receptor, tyrosine kinase) EphA7 is a receptor for members of the ephrin-a family (binds to ephrin-a1, -a2, -a3, -a4 and -a5) and is a protein tyrosine kinase. EPHA7
50 EphA8 EphA8 (ephrin receptor, tyrosine kinase) EphA8 is a receptor for members of the ephrin-a family and is a protein tyrosine kinase EPHA8
51 EphB1 EphB1 (ephrin receptor, tyrosine kinase) EphB1 is a receptor for members of the ephrin-b family (binds to ephrin-b1, -b2 and -b3) and is a protein tyrosine kinase. EPHB1
52 EphB2 EphB2 (ephrin receptor, tyrosine kinase) EphB2 is a receptor for members of the ephrin-b family and is a protein tyrosine kinase. EPHB2
53 EphB3 EphB3 (ephrin receptor, tyrosine kinase) EphB3 is a receptor for members of the ephrin-b family and is a protein tyrosine kinase. EPHB3
54 EphB4 EphB4 (ephrin receptor, tyrosine kinase) EphB4 is a receptor for members of the ephrin-b family (binds to ephrin-b2) and is a protein tyrosine kinase. EPHB4
55 EphB5 EphB5 (ephrin receptor, tyrosine kinase) EphB5 is a receptor for members of the ephrin-b family and is a protein tyrosine kinase. null
56 EGFR Epidermal growth factor receptor -1 The EGF receptor may mediate the biological signal of EGF, and also of TGF-alpha, amphiregulin, heparin-binding EGF, gp30 and vaccinia virus growth factor. EGFR
57 EGFR-2 Epidermal growth factor receptor -2 The EGF receptor may mediate the biological signal of EGF, and also of TGF-alpha, amphiregulin, heparin-binding EGF, gp30 and vaccinia virus growth factor. EGFR
58 ErbB2 ErbB2 (receptor protein-tyrosine kinase) ErbB2 (also known as Her2 or Neu) is a membrane tyrosine kinase, and a potential receptor for neuregulins and gp30. The gene is amplified in some tumors, particularly breast tumors. ERBB2
59 ESP ESP (protein tyrosine phosphatase) null null
60 FAK FAK (focal adhesion tyrosine kinase) Focal adhesion kinase 1 is a protein tyrosine kinase that is widely expressed in T and B lymphocytes. PTK2
61 FAP-1 FAP-1 (Fas-associated phosphatase-1) Fas-associated phosphatase-1 is a negative regulator of Fas-mediated apoptosis. PTPN13
62 FER FER (proto-oncogene tyrosine-protein kinase) Fer is a non-receptor protein tyrosine kinase. FER
63 FES FES (proto-oncogene tyrosine-protein kinase) FES is a proto-oncogene tyrosine-protein kinase and a homolog of feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogenes. FES
64 FGF2 FGF2 (fibroblast growth factor 2, basic) FGF2 binds heparin and may be an angiogenic agent in vivo and a mitogen for a variety of cell types. FGF2
65 FGFR2 FGFR2 (fibroblast growth factor receptor 2) FGFR2 is a receptor for acidic and basic fibroblast growth factors and a protein tyrosine kinase. FGFR2
66 Fgr Fgr (proto-oncogene tyrosine-protein kinase) Fgr is a proto-oncogene tyrosine-protein kinase and a member of the Src family. FGR
67 Fgfr-1 Fibroblast growth factor receptor 1 (receptor tyrosine kinase) -1 Fgfr1 is a receptor for basic fibroblast growth factor and is a tyrosine kinase. FGFR1
68 Fgfr-1 Fibroblast growth factor receptor 1 (receptor tyrosine kinase) -2 Fgfr1 is a receptor for basic fibroblast growth factor and is a tyrosine kinase. FGFR1
69 Fgfr-2 Fibroblast growth factor receptor 2 FGFR2 is a receptor for acidic and basic fibroblast growth factors and a protein tyrosine kinase. FGFR2
 
70 Fgfr-3 Fibroblast growth factor receptor 3 Fgfr3 belongs to the fibroblast growth factor receptor family. FGFR3
71 Fgfr-4 Fibroblast growth factor receptor 4 Fgfr4 is a receptor for acidic fibroblast growth factor. FGFR4
72 FLK1 FLK1 (receptor for vegf or vegf-c, tyrosine kinase) FLK1 is a receptor for vascular endothelial growth factor (VEGF or VEGF-c) and a protein tyrosine kinase. KDR
73 FLK2 FLK2 (receptor tyrosine kinase) FLT3 is a receptor for the FL cytokine and a protein tyrosine kinase. FLT3
74 FLT1 FLT1 (receptor for vegf and plgf, tyrosine kinase) FLT1 is a receptor for vascular endothelial growth factor (VEGF and PLGF) and a protein tyrosine kinase. FLT1
75 FLT4 FLT4 (receptor for vegf-c, tyrosine kinase) FLT4 is a receptor for vascular endothelial growth factor (VEGF-C) and a protein tyrosine kinase. FLT4
76 FRK FRK (fyn-related tyrosine kinase) Fyn-related kinase belongs to the src family of protein tyrosine kinases. FRK
77 Fyn Fyn (proto-oncogene tyrosine-protein kinase) Fyn is a proto-oncogene tyrosine-protein kinase and a member of the Src family. FYN
78 G1 Arrest after 630 Gy X-Ray G1 Arrest after 630 Gy X-Ray The ability of cells to arrest in the G1 phase of the cell cycle following X-irradiation is dependent on a functional checkpoint. null
79 Gadd34 Gadd34 (DNA-damage-inducible transcript) basal levels GADD34 is a DNA damage-inducible factor whose expression may lead to apoptosis. PPP1R15A
80 Gadd45 Gadd45 (DNA-damage-inducible transcript 1) mRNA induction after X-ray Gadd45 binds to proliferating cell nuclear antigen (might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. GADD45A
81 Gadd45 basal level Gadd45 (DNA-damage-inducible transcript 1)basal levels Gadd45 binds to proliferating cell nuclear antigen (might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. GADD45A
 
82 Gamma Glu Cys synthetase Gamma Glu Cys synthetase Glutamate--cysteine ligase performs the first and rate-limiting step in de novo glutathione biosynthesis. Glutathione prevents cellular free radical damage. GCLC
GCLM
83 Gamma Glu transpeptidase Gamma Glu transpeptidase Gamma-glutamyltranspeptidase plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione. Glutathione prevents cellular free radical damage. GGT1
GGT2
GGT3
84 GLEPP1 GLEPP1 (protein tyrosine phosphatase, receptor type) GLEPP1 is a receptor type protein tyrosine phosphatase. PTPRO
85 GFAP Glial fibrillary acidic protein (GFAP) 56kD The solid tumor lines were characterized individually using immunocytochemical techniques to determine their relative degrees of representativity for the subpanels within which they are grouped. GFAP
86 Glutathione s-transferase mu Glutathione s-transferase mu Glutathione S-transferases prevent cellular free radical damage. GSTM1
GSTM2
GSTM3
GSTM4
GSTM5
87 Glutathione s-transferase pi-1 Glutathione s-transferase pi-1 Glutathione S-transferases prevent cellular free radical damage. GSTP1
88 Glutathione s-transferase pi-2 Glutathione s-transferase pi-2 Glutathione S-transferases prevent cellular free radical damage. GSTP1
89 Glyoxylase I Glyoxylase I Glyoxylase I catalyzes the formation of s-lactoylglutathione. GLO1
90 HA2 HA2 (protein-tyrosine phosphatase) HA2 is a protein tyrosine phosphatase. null
91 Hck Hck (hemopoietic cell tyrosine kinase) Hemopoietic cell kinase (Hck) is a protein tyrosine kinase and a member of the Src family. HCK
92 Her2 Her2 (Receptor protein-tyrosine kinase Erbb-2) ErbB2 (also known as Her2 or Neu) is a membrane tyrosine kinase, and a potential receptor for neuregulins and gp30. The gene is amplified in some tumors, particularly breast tumors. ERBB2
93 Her3 HER3 (erbb-3 receptor protein-tyrosine kinase) ErbB3 is a tyrosine kinase receptor and may be activated by neuregulins and NTAK. It is overexpressed in some breast tumors. ERBB3
94 Her4 Her4 (Receptor protein-tyrosine kinase Erbb-4) ErbB4 is a tyrosine kinase receptor and may be activated neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. ERBB4
95 hMLH1 hMLH1 (DNA mismatch repair protein) Mlh1 is involved in the repair of mismatches in DNA. Defects in Mlh1 have been associated with familial hereditary nonpolyposis colon cancer (HNPCC). MLH1
96 hMLH2 hMLH2 (DNA mismatch repair protein) Msh2 is involved in the repair of mismatches in DNA. Defects in Msh2 have been associated with familial hereditary nonpolyposis colon cancer (HNPCC). MSH2
97 HSC HSC (tyrosine kinase) null null
98 IA2 IA2 (protein tyrosine phosphatase, receptor type) IA2 is a protein-tyrosine phosphatase with a possible role in neuroendocrine secretory processes. PTPRN
99 IAR IAR (protein tyrosine phosphatase, receptor type) IAR is a protein-tyrosine phosphatase. PTPRN2
100 IGF1R IGF1R (insulin-like growth factor 1 receptor, tyrosine kinase) Insulin-like growth factor 1 receptor is a protein tyrosine kinase and binds IGF I with a high affinity and IGF II with a lower affinity IGF1R
101 INSR INSR (insulin receptor, tyrosine kinase) The insulin receptor is a protein tyrosine kinase. INSR
102 IRR IRR (insulin receptor-related receptor, tyrosine kinase) INSRR is a receptor tyrosine kinase related to the insulin receptor. INSRR
103 ITK ITK (IL2-inducible T-cell tyrosine kinase) IL2-inducible T-cell kinase is a protein tyrosine kinase expressed mainly in T-cells and NK cells. ITK
104 JAK-1 JAK1 (Janus kinase 1, protein tyrosine kinase) Janus kinase 1 is a non-receptor-type protein tyrosine kinase and is a kinase partner for the interleukin (IL)-2 receptor. JAK1
105 JAK-2 JAK2 (Janus kinase 2, protein tyrosine kinase) Janus kinase 2 is a non-receptor-type protein tyrosine kinase and may be involved in interleukin 3 signal transduction. JAK2
106 KDR KDR (receptor tyrosine kinase) KDR is a receptor for vascular endothelial growth factor (VEGF or VEGF-C) and a protein tyrosine kinase. KDR
107 KIT KIT (receptor for stem cell factor, tyrosine kinase) Kit is a receptor for stem cell factor (mast cell growth factor) and a tyrosine-protein kinase. It is a homolog of the v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene. KIT
108 LAR LAR (protein tyrosine phosphatase, receptor type) LAR is a receptor-type protein tyrosine phosphatase. PTPRF
109 LC LC (protein tyrosine phosphatase) LC-PTP is a non-receptor-type protein tyrosine phosphatase. PTPN7
110 Lck Lck (proto-oncogene tyrosine-protein kinase) Lymphocyte-specific protein tyrosine kinase (Lck) is a proto-oncogene and a member of the Src family. LCK
111 LRP LRP (Drug efflux pump) null null
112 LTK LTK (leukocyte tyrosine kinase receptor) Leukocyte tyrosine kinase belongs to the insulin receptor family. LTK
113 Lyn Lyn (tyrosine-protein kinase) Lyn is a proto-oncogene tyrosine-protein kinase and a member of the Src family. LYN
114 MDM2 MDM2 (p53 binding protein) Mdm2 binds to p53 and can downregulate p53 function. MDM2
115 MDM2 basal levels MDM2 (p53-binding protein) basal levels Mdm2 binds to p53 protein forming a tight complex. Can inhibit p53-mediated transactivation. MDM2
116 Mdr1 Mdr1 (Multidrug resistance gene) Drug resistance is a major reason for the failure of cancer chemotherapy. One widely studied mechanism of drug resistance involves the ability of P-glycoprotein to act as a drug efflux pump. ABCB1
117 MEG MEG (megakaryocyte protein tyrosine phosphatase) PTP-MEG is a non-receptor-type protein tyrosine phosphatase. PTPN4
118 MEG-2 Meg2 (protein-tyrosine phosphatase) PTP-Meg2 is a non-receptor-type protein tyrosine phosphatase. PTPN9
119 MER MER (proto-oncogene tyrosine kinase) c-mer proto-oncogene tyrosine kinase may bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6). MERTK
120 MET MET (hepatocyte growth factor receptor, tyrosine kinase) The met proto-oncogene is a receptor for hepatocyte growth factor and is a protein tyrosine kinase. MET
121 Metallothionein Metallothionein (whole cell) Because of the high cysteine content in mettalothioneins (MTs), these low molecular weight proteins bind heavy metals and protect cells against the toxicity of metals such as Cd. Previous studies have also implicated MT in resistance to some anticancer drugs and mutagens. MT1A
MT1B
MT1E
MT1F
MT1G
MT1H
MT1I
MT1J
MT1K
MT1L
MT1Q
MT1S
MT1X
MT2A
MT3
122 metallothionein nuclear/cytoplasm ratio metallothionein nuclear/cytoplasm ratio null MT1A
MT1B
MT1E
MT1F
MT1G
MT1H
MT1I
MT1J
MT1K
MT1L
MT1Q
MT1S
MT1X
MT2A
MT3
123 MGMT MGMT (O-6-methylguanine-DNA methyltransferase) expression O-6-methylguanine-DNA methyltransferase repairs alkylated guanines in DNA. MGMT
124 MRP MRP (Drug efflux pump) Drug resistance is a major reason for the failure of cancer chemotherapy. One widely studied mechanism of drug resistance involves the ability of P-glycoprotein to act as a drug efflux pump. ABCC1
125 Mrp Mrp (Multidrug resistance protein) Drug resistance is a major reason for the failure of cancer chemotherapy. One widely studied mechanism of drug resistance involves the ability of P-glycoprotein to act as a drug efflux pump. ABCC1
126 MUSK MUSK (muscle, skeletal, receptor tyrosine kinase) MUSK is a skeletal muscle specific receptor tyrosine kinase. MUSK
127 Mutation of N-ras, K-ras and H-ras Mutation of N-ras, K-ras and H-ras Activation of RAS results in the recruitment of the serine/threonine protein kinase RAF to the plasma membrane, activating a MAP kinase signal transduction cascade. HRAS
KRAS2
NRAS
128 NADPH Cytochrome P450 reductase NADPH Cytochrome P450 reductase (Waxman) Many antitumor drugs either undergo P450 enzyme-catalyzed metabolism leading to drug inactivation, or in some cases require metabolic activation catalyzed by P450 enzymes, to exert their cytotoxic or cytostatic effects. POR
129 Neurofilament 70 and 200kD Neurofilament 70 and 200kD The solid tumor lines were characterized individually using immunocytochemical techniques to determine their relative degrees of representativity for the subpanels within which they are grouped. INA
NEF3
NEFH
NEFL
PRPH
130 Nm23 Nm23 (protein expressed in non-metastatic cells) Nm23 (nucleoside diphosphate kinase) was initially identified as being associated with non-metastatic cancers. Reduced levels of nm23 have been associated with poor prognosis for some types of cancer. NME1
NME2
NME3
NME4
NME5
131 p-AKT P(ser473)AKT (Dajun) AKT is a Ser-Thr kinase important in cell signaling via the PI3K pathway, is activated by phosphorylation, and is constitutively activated in some tumors. AKT is negatively regulated by PTEN. AKT1
AKT2
AKT3
132 p53 p53 p53 is a tumor suppressor that is responsible for inducing cell cycle arrest or apoptosis in response to cellular stress. TP53
133 P53 functional assay (cDNA) P53 functional assay (cDNA) p53 is a tumor suppressor that is responsible for inducing cell cycle arrest or apoptosis in response to cellular stress. TP53
134 P53 mutation (cDNA) P53 mutation (cDNA) p53 is a tumor suppressor that is responsible for inducing cell cycle arrest or apoptosis in response to cellular stress. TP53
135 P53 protein P53 protein p53 is a tumor suppressor that is responsible for inducing cell cycle arrest or apoptosis in response to cellular stress. TP53
136 PCP-2 (tyrosine kinase) PCP-2 (tyrosine kinase) PCP-2 is a receptor-type tyrosine phosphatase. PTPRU
137 PDGFRa PDGFRa (pdgf-a or pdgf-b receptor, tyrosine kinase) Platelet-derived growth factor receptor, alpha can bind either PDGF-A or PDGF-B and is a protein tyrosine kinase. PDGFRA
138 PDGFRb PDGFRb (pdgf-b receptor, tyrosine kinase) Platelet-derived growth factor receptor, beta binds specifically to PDGF-B and is a protein tyrosine kinase. PDGFRB
139 PEST PEST (protein-tyrosine phosphatase) PTP-PEST is a non-receptor-type protein tyrosine phosphatase. Defects in PTP-PEST have been found in some colon cancers. PTPN12
140 PEZ PEZ (protein-tyrosine phosphatase) PEZ is a non-receptor-type protein tyrosine phosphatase. PTPN14
141 PTEN PTEN (Dajun) AKT is a Ser-Thr kinase important in cell signaling via the PI3K pathway, is activated by phosphorylation, and is constitutively activated in some tumors. AKT is negatively regulated by PTEN. PTEN
142 PTP-1B PTP-1B (protein tyrosine phosphatase) PTP-1B is a non-receptor-type protein tyrosine phosphatase. PTPN1
143 PTP-36 PTP-36 (protein tyrosine phosphatase) null null
144 PTP-a PTP-a (protein-tyrosine phosphatase) null PTPRA
145 PTP-b PTP-b (protein-tyrosine phosphatase) null PTPRB
146 PTP-d PTP-d (protein-tyrosine phosphatase) null PTPRD
147 PTP-D1 PTP-D1 (protein tyrosine phosphatase) null PTPN21
148 PTP-e PTP-e (protein-tyrosine phosphatase) null PTPRE
149 PTP-g PTP-g (protein-tyrosine phosphatase) null PTPRG
150 PTP-k PTP-k (protein-tyrosine phosphatase) null PTPRK
151 PTP-m PTP-m (protein-tyrosine phosphatase) null PTPRM
152 PTP-s PTP-s (protein-tyrosine phosphatase) null PTPRS
153 PTP-S31 PTP-S31 (protein-tyrosine phosphatase) null null
154 PTP-SL PTP-SL (protein tyrosine phosphatase, receptor type) PTP-SL is a receptor-type protein tyrosine phosphatase. PTPRR
155 PTP-z PTP-z (protein-tyrosine phosphatase) null PTPRZ1
156 PTP20 PTP20 (protein-tyrosine phosphatase) null null
157 PYK2 PYK2 (protein tyrosine kinase) PYK2 is a protein tyrosine kinase. PTK2B
158 Reduced folate carrier Reduced folate carrier A transporter for the uptake of folate. SLC19A1
159 RET RET (proto-oncogene tyrosine-protein kinase receptor) The ret proto-oncogene is a receptor-type protein tyrosine kinase and is associated with a number of related familial cancer syndromes. RET
160 Rhodamine exclusion Rhodamine exclusion (MDR activity) Drug resistance is a major reason for the failure of cancer chemotherapy. One widely studied mechanism of drug resistance involves the ability of P-glycoprotein to act as a drug efflux pump. null
161 RON RON (macrophage stimulating protein receptor, tyrosine kinase) RON is a receptor for macrophage stimulating protein (MSP) and is a protein tyrosine kinase. MST1R
162 ROR1 ROR1 (neurotrophic tyrosine kinase receptor-related) Ror1 is an orphan cell surface receptor and and may be a protein tyrosine kinase. ROR1
163 ROR2 ROR2 (neurotrophic tyrosine kinase receptor-related) Ror2 may be a receptor protein tyrosine kinase. ROR2
164 ROS ROS (proto-oncogene tyrosine-protein kinase) ROS is receptor-type protein tyrosine kinase and a homolog of the v-ros avian UR2 sarcoma virus oncogene. ROS1
165 RPTPx RPTPx (protein tyrosine phosphatase, receptor type) null PTPRN2
166 RYK RYK (receptor-like tyrosine kinase) RYK is receptor-type protein tyrosine kinase. RYK
167 S-100 protein S-100 protein The solid tumor lines were characterized individually using immunocytochemical techniques to determine their relative degrees of representativity for the subpanels within which they are grouped. S100A1
S100A10
S100A11
S100A12
S100A13
S100A14
S100A2
S100A3
S100A4
S100A5
S100A6
S100A7
S100A8
S100A9
S100B
S100P
168 SAP SAP (protein tyrosine phosphatase, receptor type) PTP-SAP is a receptor-type protein tyrosine phosphatase. PTPRH
169 SHP1 SHP1 (protein tyrosine phosphatase) SHP1 is a protein tyrosine phosphatase with a possible role in T-cell receptor signalling. PTPN6
170 SHP2 SHP2 (protein tyrosine phosphatase) SHP2 is a non-receptor type protein tyrosine phosphatase. PTPN11
171 Src Src (proto-oncogene tyrosine-protein kinase) -1 Src is a proto-oncogene tyrosine-protein kinase. SRC
172 Src Src (proto-oncogene tyrosine-protein kinase) -2 Src is a proto-oncogene tyrosine-protein kinase. SRC
173 STEP STEP (protein-tyrosine phosphatase) PTP-STEP is a non-receptor-type protein tyrosine phosphatase. PTPN5
174 SYK SYK (spleen tyrosine kinase) Spleen tyrosine kinase may have a role in lymphocyte activation. SYK
175 TC-PTP TC-PTP (protein tyrosine phosphatase) T-cell protein-tyrosine phosphatase belongs to the non-receptor class of the protein- tyrosine phosphatase family. PTPN2
176 TEC TEC (protein tyrosine kinase) Tec is a non-receptor protein tyrosine kinase. TEC
177 TEK TEK (tyrosine kinase, endothelial) TEK is an endothelial-specific receptor tyrosine kinase that may be involved in angiogenesis. TEK
178 TGF-alpha TGF-alpha (Transforming growth factor, alpha) TGF-alpha is a ligand for EGF receptor, and is part of a growth factor receptor-signaling pathway. TGFA
179 Thioredoxin Thioredoxin Thioredoxin and thioredoxin reductase are redox proteins that have been implicated in the control of cell proliferation and transformation. Secretion of thioredoxin, which is known to have a direct growth stimulating activity, by human tumor cells might lead to the stimulation of cancer cell growth. TXN
180 Thioredoxin reductase Thioredoxin reductase Thioredoxin and thioredoxin reductase are redox proteins that have been implicated in the control of cell proliferation and transformation. Secretion of thioredoxin, which is known to have a direct growth stimulating activity, by human tumor cells might lead to the stimulation of cancer cell growth. TXNRD1
181 Thymidine kinase Thymidine kinase Thymidine kinase is involved in the pyrimidine salvage pathway. It is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates anti-viral and anti-cancer nucleoside analogs. TK1
TK2
182 Thymidylate synthase Thymidylate synthase Thymidylate synthetase is part of the pyrimidine biosynthetic pathway. TYMS
183 Thymidylate synthetase Thymidylate synthetase Thymidylate synthetase is involved in the pyrimidine biosynthetic pathway. TYMS
184 TIE TIE (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains) TIE is a receptor tyrosine kinase that may be involved in angiogenesis. TIE
185 TNK1 TNK1 (protein tyrosine kinase) TNK1 is a non-receptor type tyrosine kinase. TNK1
186 Topoisomerase II beta Topoisomerase II beta Topoisomerase II changes supercoiling of DNA and is required for a variety of cellular processes, including DNA replication and chromosome segregation. Drugs that target Topo II can cause double-stranded DNA breaks. TOP2B
187 Topoisomerase II alpha Topoisomerase II alpha Topoisomerase II changes supercoiling of DNA and is required for a variety of cellular processes, including DNA replication and chromosome segregation. Drugs that target Topo II can cause double-stranded DNA breaks. TOP2A
188 TRKA TRKA (high affinity nerve growth factor receptor, tyrosine kinase) TRKA is a receptor tyrosine kinase that has high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5. NTRK1
189 TRKB TRKB (bdnf/nt-3 growth factors receptor, tyrosine kinase) TRKB is a receptor tyrosine kinase that binds brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5. NTRK2
190 TRKC TRKC (neurotrophin-3 receptor, tyrosine kinase) TRKC is a receptor tyrosine kinase that binds neurotrophin-3 (NT-3). NTRK3
191 TXK TXK (protein tyrosine kinase) TXK is a non-receptor type tyrosine kinase. TXK
192 TYK2 TYK2 (protein tyrosine kinase) TYK2 is a non-receptor tyrosine-protein kinase that may be involved in cytokine signalling. TYK2
193 Type I acidic keratins Type I acidic keratins The solid tumor lines were characterized individually using immunocytochemical techniques to determine their relative degrees of representativity for the subpanels within which they are grouped. null
194 Type II basic keratins Type II basic keratins The solid tumor lines were characterized individually using immunocytochemical techniques to determine their relative degrees of representativity for the subpanels within which they are grouped. null
195 TYRO10 TYRO10 (neurotrophic tyrosine kinase, receptor-related 3) TYRO10 may be a receptor tyrosine kinase. DDR2
196 Vimentin 57kD Vimentin 57kD The solid tumor lines were characterized individually using immunocytochemical techniques to determine their relative degrees of representativity for the subpanels within which they are grouped. VIM
197 Waf-1 Waf-1 (cyclin-dependent kinase inhibitor 1A) basal levels CIP1/WAF1 may be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. May bind to and inhibit cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. CDKN1A
198 Waf1 Waf1 (cyclin-dependent kinase inhibitor 1A) mRNA induction after ionizing radiation CIP1/WAF1 may be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. May bind to and inhibit cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. CDKN1A
199 x-iap3 x-iap (mRNA level apoptosis inhibitor 3) X-iap is an inhibitor of caspase-3 and caspase-7 and blocks apoptosis. BIRC4
200 X-IAP X-IAP (x-linked inhibitor of apoptosis) X-iap is an inhibitor of caspase-3 and caspase-7 and blocks apoptosis. BIRC4
201 Yes Yes (proto-oncogene tyrosine-protein kinase) Yes1 is a tyrosine kinase and a member of the Src family. YES1
202 ZAP70 ZAP70 (zeta-chain (TCR) associated protein tyrosine kinase) ZAP70 is a tyrosine kinase that associates with the T-cell receptor zeta chain. ZAP70
203 ZPEP ZPEP (protein tyrosine kinase) null null